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Dr Grant MacKenzie

MBBS BMedSci PGDipBiostats MPH FRACP PhD

Associate Professor
Clinical Epidemiology

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
+220 5669255

I trained as a paediatrician in Australia and completed my PhD focussing on the impact of pneumococcal conjugate vaccine (PCV) on otitis media and pneumonia and vaccine immunogenicity. The then worked for 2 years in paediatric HIV in London and Nairobi. I then moved to the MRC Unit in The Gambia to coordinate surveillance to measure the impact of the routine introduction of PCV. I am a clinical field epidemiologist with a statistical background with a focus to link clinical, epidemiological, immunological and microbiological investigations.

Affiliations

Department of Disease Control

Centres

Vaccine Centre

Teaching

I teach on the module for Control of Communicable Disease in LSHTM Master's degrees as well as supervising PhD and summer projects for Master's degree students.

Research

I have been a Clinical Epidemiologist at the Basse Field Station of the MRC Unit The Gambia at LSHTM since 2008. My research falls under the Disease Control and Elimination Theme. I co-ordinate surveillance for pneumococcal disease and carriage in eastern Gambia, evaluating the effectiveness of the introduction of pneumococcal conjugate vaccine (PCV) to reduce rates of invasive disease, radiologic pneumonia, pneumococcal carriage, and the cost-effectiveness of vaccination. I am conducting a large cluster-randomised study comparing the standard 3+0 schedule for PCV to an alternative 1+1 schedule. The aim of the study is to determine in a typical African setting where PCV has been used for some time, whether transition to a 1+1 schedule is safe and effective.

I am also studying the aetiology of pneumonia, documenting short and long-term outcomes after childhood pneumonia, socio-economic risk factors for pneumonia, evaluating IMCI criteria for pneumonia, and describing the epidemiology of pneumonia and the causes of serious bacterial illness.

Discipline
Bacteriology
Epidemiology
Medicine
Vaccinology
Country
Australia
United Kingdom
The Gambia
Senegal
Region
Sub-Saharan Africa (developing only)

Selected Publications

Changes in Invasive Pneumococcal Disease Caused by Streptococcus pneumoniae Serotype 1 Following Introduction of PCV10 and PCV13: Findings from the PSERENADE Project.
Bennett JC; Hetrich MK; Garcia Quesada M; Sinkevitch JN; Deloria Knoll M; Feikin DR; Zeger SL; Kagucia EW; Cohen AL; Ampofo K
2021
Microorganisms
Global Landscape Review of Serotype-Specific Invasive Pneumococcal Disease Surveillance among Countries Using PCV10/13: The Pneumococcal Serotype Replacement and Distribution Estimation (PSERENADE) Project.
Deloria Knoll M; Bennett JC; Garcia Quesada M; Kagucia EW; Peterson ME; Feikin DR; Cohen AL; Hetrich MK; Yang Y; Sinkevitch JN
2021
Microorganisms
Impact of the introduction of pneumococcal conjugate vaccination on invasive pneumococcal disease and pneumonia in The Gambia: 10 years of population-based surveillance.
Gambia Pneumococcal Surveillance Group; Mackenzie GA; Hill PC; Jeffries DJ; Ndiaye M; Sahito SM; Hossain I; Uchendu U; Ameh D; Adeyemi O
2021
Lancet Infect Dis
Molecular Epidemiology of Group A Streptococcus Infections in The Gambia.
Jabang S; Erhart A; Darboe S; Baldeh A-K; Delforge V; Watson G; Foster-Nyarko E; Salaudeen R; Lawal B; Mackenzie G
2021
Vaccines
Aetiology of Lobar Pneumonia Determined by Multiplex Molecular Analyses of Lung and Pleural Aspirate Specimens in The Gambia
Mackenzie GA; McLellan J; Machuka E; Ndiaye M; Pathirana J; Fombah A; Abatan B; Hossain I; Manjang A; Greenwood B
2021
Upper Respiratory Tract Co-detection of Human Endemic Coronaviruses and High-density Pneumococcus Associated With Increased Severity Among HIV-Uninfected Children Under 5 Years Old in the PERCH Study.
Park DE; Higdon MM; Prosperi C; Baggett HC; Brooks WA; Feikin DR; Hammitt LL; Howie SRC; Kotloff KL; Levine OS
2021
Pediatric Infectious Disease Journal
Invasive Haemophilus influenzae Infections after 3 Decades of Hib Protein Conjugate Vaccine Use.
Slack MPE; Cripps AW; Grimwood K; Mackenzie GA; Ulanova M
2021
Clinical microbiology reviews
The development and implementation of an oxygen treatment solution for health facilities in low and middle-income countries.
Howie SR; Ebruke BE; Gil M; Bradley B; Nyassi E; Edmonds T; Boladuadua S; Rasili S; Rafai E; Mackenzie G
2020
Journal of global health
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