Dr Grant MacKenzie
MBBS BMedSci PGDipBiostats MPH FRACP PhD
I trained as a paediatrician in Australia and completed my PhD focussing on the impact of pneumococcal conjugate vaccine (PCV) on otitis media and pneumonia and vaccine immunogenicity. The then worked for 2 years in paediatric HIV in London and Nairobi. I then moved to the MRC Unit in The Gambia to coordinate surveillance to measure the impact of the routine introduction of PCV. I am a clinical field epidemiologist with a statistical background with a focus to link clinical, epidemiological, immunological and microbiological investigations.
I teach on the module for Control of Communicable Disease in LSHTM Master's degrees as well as supervising PhD and summer projects for Master's degree students.
I have been a Clinical Epidemiologist at the Basse Field Station of the MRC Unit The Gambia at LSHTM since 2008. My research falls under the Disease Control and Elimination Theme. I co-ordinate surveillance for pneumococcal disease and carriage in eastern Gambia, evaluating the effectiveness of the introduction of pneumococcal conjugate vaccine (PCV) to reduce rates of invasive disease, radiologic pneumonia, pneumococcal carriage, and the cost-effectiveness of vaccination. I am conducting a large cluster-randomised study comparing the standard 3+0 schedule for PCV to an alternative 1+1 schedule. The aim of the study is to determine in a typical African setting where PCV has been used for some time, whether transition to a 1+1 schedule is safe and effective.
I am also studying the aetiology of pneumonia, documenting short and long-term outcomes after childhood pneumonia, socio-economic risk factors for pneumonia, evaluating IMCI criteria for pneumonia, and describing the epidemiology of pneumonia and the causes of serious bacterial illness.