Dr Catherine Ludden
Catherine Ludden performed her PhD at the National University of Ireland Galway (2010-2104), which focused on the genetic diversity, transmission and evolution of antimicrobial resistant bacteria in nursing homes and hospitals. She was a Postdoctoral Fellow in Prof. Sharon Peacock's group at the Department of Medicine, University of Cambridge from 2014-2016. In April 2016, she joined the Department of Infectious and Tropical Diseases as a Sir Henry Wellcome Fellow. Her current research is based on a One Health approach to investigate the origin and transmission of antimicrobial-resistant E. coli in the UK. This involves the use of whole-genome sequencing to determine the genetic relatedness of isolates and associated mobile genetic elements from different sources to define shared reservoirs. She is also working on integrating whole genome sequencing into health services for the surveillance of Carbapenem resistant Enterobacteriaceae in Ireland.
Teaching the module for Practical Procedures in Clinical Microbiology to medical students, including laboratory supervision, practical demonstration, project design, laboratory report corrections and tutorials.
The bacterium Escherichia coliis a major cause of infections in people in hospitals and the community. E. coli can become resistant to commonly used antibiotics through the acquisition of resistance-encoding genes. When people are infected with these strains, their infection can be difficult to treat and they are at a higher risk of death.
Catherine Ludden's research is based on a One Health approach to investigate the origin and transmission of antimicrobial-resistant E. coli in the UK.She will use genome sequence data of antimicrobial-resistant E. coli from hospitalised haematology patients, the hospital environment, livestock, wastewater and bloodstream infections in the UK to determine the genetic relatedness of isolates and associated mobile genetic elements from these different sources to define shared reservoirs. Mathematical modelling will be used to infer transmission, test hypotheses and to determine the likely impact of interventions to reduce transmission of antimicrobial-resistant E. coli.
She is also involved in the development a National Surveillance programme for Carbapenem resistant Enterobacteriaceae in Ireland and integrating whole genome sequencing into health services. This will provide evidence on antimicrobial resistance reservoirs, routes of transmission between them and detection of novel mechanisms of resistance in emerging strains.