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Dr Catherine Ludden

PhD

Research Fellow

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Dr Catherine Ludden is a genomic epidemiologist and is currenlty on secondment at the COVID-19 Genomics UK Consortium (COG-UK) where she is Director of Operations. She is responsible for overseeing COG-UK operations, developing long-term operational strategies, coordinating public health investigations, and engaging with technical experts, collaborators and senior leaders. Catherine also holds the position of Head of Operations for the Pathogen Genomics COVID Programme at Public Health England (PHE) and is responsible for the service delivery of SARS-CoV-2 genomics in the UK and the continuous genomic service improvement. Catherine has strong expertise in pathogen genomics, antibiotic resistance, and clinical microbiology. Prior to joining COG-UK and PHE, Catherine was working with the European Centre for Disease Prevention and Control where she provided scientific and technical expertise for the analysis and interpretation of European whole genome sequencing datasets and supported international outbreak investigations. She is a One Heath expert and holds a Sir Henry Postdoctoral Wellcome Fellowship at the London School of Hygiene and Tropical Medicine to define reservoirs and transmission of antimicrobial-resistant Escherichia coli using a One Health approach.


Affiliations

Department of Clinical Research
Department of Infection Biology

Centres

Centre for the Mathematical Modelling of Infectious Diseases (CMMID)
Antimicrobial Resistance Centre (AMR)

Teaching

Teaching the module for Practical Procedures in Clinical Microbiology to medical students, including laboratory supervision, practical demonstration, project design, laboratory report corrections and tutorials.

Teaching the topic of "One Health" on the short course entitled Antimicrobial Resistance (AMR): a Multidisciplinary Approach.

Research

The bacterium Escherichia coli is a major cause of infections in people in hospitals and the community. E. coli can become resistant to commonly used antibiotics through the acquisition of resistance-encoding genes. When people are infected with these strains, their infection can be difficult to treat and they are at a higher risk of death. 

Catherine Ludden's research is based on a One Health approach to investigate the origin and transmission of antimicrobial-resistant E. coli in the UK. She will use genome sequence data of antimicrobial-resistant E. coli from hospitalised haematology patients, the hospital environment, livestock, wastewater and bloodstream infections in the UK to determine the genetic relatedness of isolates and associated mobile genetic elements from these different sources to define shared reservoirs. Mathematical modelling will be used to infer transmission, test hypotheses and to determine the likely impact of interventions to reduce transmission of antimicrobial-resistant E. coli.

She is also involved in the development a National Surveillance programme for Carbapenem resistant Enterobacteriaceae in Ireland and integrating whole genome sequencing into health services. This will provide evidence on antimicrobial resistance reservoirs, routes of transmission between them and detection of novel mechanisms of resistance in emerging strains.

Research Area
Bacteria
Drug resistance
Environment
Health care policy
Public health
Sanitation
Surveillance
Water
Disease control
Environmental Health
Global Health
Outbreaks
Modelling
Discipline
Genetic epidemiology
Genomics
Molecular epidemiology
Bacteriology
Epidemiology
Medicine
Microbiology
Mathematical modelling
Molecular biology
Disease and Health Conditions
Emerging Infectious Disease
Hospital acquired infection

Selected Publications

Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 variant of concern 202012/01 (B.1.1.7): an exploratory analysis of a randomised controlled trial.
Emary KRW; Golubchik T; Aley PK; Ariani CV; Angus B; Bibi S; Blane B; Bonsall D; Cicconi P; Charlton S
2021
Lancet (London, England)
Defining nosocomial transmission of Escherichia coli and antimicrobial resistance genes: a genomic surveillance study.
Ludden C; Coll F; Gouliouris T; Restif O; Blane B; Blackwell GA; Kumar N; Naydenova P; Crawley C; Brown NM
2021
The Lancet Microbe
Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity.
Volz E; Hill V; McCrone JT; Price A; Jorgensen D; O'Toole Á; Southgate J; Johnson R; Jackson B; Nascimento FF
2021
Cell
Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020.
Alm E; Broberg EK; Connor T; Hodcroft EB; Komissarov AB; Maurer-Stroh S; Melidou A; Neher RA; O'Toole Á; Pereyaslov D
2020
EUROSURVEILLANCE
Quantifying acquisition and transmission of Enterococcus faecium using genomic surveillance.
Gouliouris T; Coll F; Ludden C; Blane B; Raven KE; Naydenova P; Crawley C; Török ME; Enoch DA; Brown NM
2020
Nature microbiology
One Health Genomic Surveillance of Escherichia coli Demonstrates Distinct Lineages and Mobile Genetic Elements in Isolates from Humans versus Livestock.
Ludden C; Raven KE; Jamrozy D; Gouliouris T; Blane B; Coll F; de Goffau M; Naydenova P; Horner C; Hernandez-Garcia J
2019
mBio
Genomic Surveillance of Enterococcus faecium Reveals Limited Sharing of Strains and Resistance Genes between Livestock and Humans in the United Kingdom.
Gouliouris T; Raven KE; Ludden C; Blane B; Corander J; Horner CS; Hernandez-Garcia J; Wood P; Hadjirin NF; Radakovic M
2018
mBio
Within-host evolution of Enterococcus faecium during longitudinal carriage and transition to bloodstream infection in immunocompromised patients.
Moradigaravand D; Gouliouris T; Blane B; Naydenova P; Ludden C; Crawley C; Brown NM; Török ME; Parkhill J; Peacock SJ
2017
Genome medicine
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