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Dr Catherine Ludden

PhD

Research Fellow

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Dr Catherine Ludden is a genomic epidemiologist specialised in investigating the origin and transmission of antimicrobial-resistant pathogens. She completed her PhD in 2014 at the National University of Ireland Galway on the genetic diversity, transmission and evolution of antimicrobial resistant pathogens in nursing homes and hospitals in Ireland. Having completed her PhD, Catherine moved to the University of Cambridge to take up a Postdoctoral Research Associate position in Professor Sharon Peacock's group at the Department of Medicine and her research was focussed on genomic epidemiology of nosocomial pathogens. In 2016, she was awarded a Sir Henry Postdoctoral Wellcome Fellowship at the London School of Hygiene and Tropical Medicine. Her fellowship is based on a One Health approach to investigate the origin and transmission of antimicrobial-resistant E. coli and K. pneumoniae in the UK. She is also working on integrating whole genome sequencing into health services for the surveillance of Carbapenem resistant Enterobacteriaceae. In 2019, Catherine went on a secondment to the European Centre for Disease Prevention and Control to provide expertise in antimicrobial resistance, healthcare associated infections and genomic analyses. She is also an International Ambassador for the Society for Healthcare Epidemiology of America. Catherine is an inspiring leader dedicated to enhancing human health through motivating others and working as part of a team to deliver high impact science. Currently, Catherine is on a secondment at COG-UK where she is Director of Operations.


Affiliations

Department of Infection Biology
Department of Clinical Research

Centres

Centre for the Mathematical Modelling of Infectious Diseases (CMMID)
Antimicrobial Resistance Centre (AMR)

Teaching

Teaching the module for Practical Procedures in Clinical Microbiology to medical students, including laboratory supervision, practical demonstration, project design, laboratory report corrections and tutorials.

Teaching the topic of "One Health" on the short course entitled Antimicrobial Resistance (AMR): a Multidisciplinary Approach.

Research

The bacterium Escherichia coli is a major cause of infections in people in hospitals and the community. E. coli can become resistant to commonly used antibiotics through the acquisition of resistance-encoding genes. When people are infected with these strains, their infection can be difficult to treat and they are at a higher risk of death. 

Catherine Ludden's research is based on a One Health approach to investigate the origin and transmission of antimicrobial-resistant E. coli in the UK. She will use genome sequence data of antimicrobial-resistant E. coli from hospitalised haematology patients, the hospital environment, livestock, wastewater and bloodstream infections in the UK to determine the genetic relatedness of isolates and associated mobile genetic elements from these different sources to define shared reservoirs. Mathematical modelling will be used to infer transmission, test hypotheses and to determine the likely impact of interventions to reduce transmission of antimicrobial-resistant E. coli.

She is also involved in the development a National Surveillance programme for Carbapenem resistant Enterobacteriaceae in Ireland and integrating whole genome sequencing into health services. This will provide evidence on antimicrobial resistance reservoirs, routes of transmission between them and detection of novel mechanisms of resistance in emerging strains.

Research Area
Bacteria
Drug resistance
Environment
Health care policy
Public health
Sanitation
Surveillance
Water
Disease control
Environmental Health
Global Health
Outbreaks
Modelling
Discipline
Genetic epidemiology
Genomics
Molecular epidemiology
Bacteriology
Epidemiology
Medicine
Microbiology
Mathematical modelling
Molecular biology
Disease and Health Conditions
Emerging Infectious Disease
Hospital acquired infection

Selected Publications

One Health Genomic Surveillance of Escherichia coli Demonstrates Distinct Lineages and Mobile Genetic Elements in Isolates from Humans versus Livestock.
Ludden C; Raven KE; Jamrozy D; Gouliouris T; Blane B; Coll F; de Goffau M; Naydenova P; Horner C; Hernandez-Garcia J
2019
mBio
Genomic Surveillance of Enterococcus faecium Reveals Limited Sharing of Strains and Resistance Genes between Livestock and Humans in the United Kingdom.
Gouliouris T; Raven KE; Ludden C; Blane B; Corander J; Horner CS; Hernandez-Garcia J; Wood P; Hadjirin NF; Radakovic M
2018
mBio
Sharing of carbapenemase-encoding plasmids between Enterobacteriaceae in UK sewage uncovered by MinION sequencing.
Ludden C; Reuter S; Judge K; Gouliouris T; Blane B; Coll F; Naydenova P; Hunt M; Tracey A; Hopkins KL
2017
Microbial genomics
Within-host evolution of Enterococcus faecium during longitudinal carriage and transition to bloodstream infection in immunocompromised patients.
Moradigaravand D; Gouliouris T; Blane B; Naydenova P; Ludden C; Crawley C; Brown NM; Török ME; Parkhill J; Peacock SJ
2017
Genome medicine
Transmission of methicillin-resistant Staphylococcus aureus in long-term care facilities and their related healthcare networks.
Harrison EM; Ludden C; Brodrick HJ; Blane B; Brennan G; Morris D; Coll F; Reuter S; Brown NM; Holmes MA
2016
Genome medicine
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