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Dr Michael Lewis

BSc MSc PhD

Assistant Professor

Room
Rm 390

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
02079272721

I obtained a BSc in Genetics in 2002 and an MSc in Medical Molecular Microbiology in 2004, both from the University of Nottingham. I later completed my PhD and early post-doctoral work on the genetics and evolution of Trypanosoma cruzi in Michael Miles' lab at LSHTM. I then undertook further post-doctoral work in John Kelly's lab where I developed bioluminescence in vivo imaging systems for T. cruzi. In 2014 I was awarded a Marie Curie Fellowship and moved to the National Institutes of Health in Bethesda, USA to work with David Sacks on the pathogenesis of visceral leishmaniasis. Since returning to LSHTM in 2016 I have continued to study host-parasite interactions and chronic disease pathogenesis.

Affiliations

Faculty of Infectious and Tropical Diseases
Department of Infection Biology

Teaching

I am involved in teaching across several of LSHTM's London-based MSc courses. I am deputy module organiser for 3160 (MBID:Research Progress & Applications) and DL203 (Parasitology) on the MSc Infectious Diseases by distance learning programme.

Research

Three of the most important neglected infectious diseases, Human African Trypanosomiasis, Chagas disease and leishmaniasis are caused by parasites from the protozoan order Trypanosomatida: Trypanosoma brucei, T. cruzi and Leishmania sp. respectively. These parasites are all able to establish long-term chronic infections in people resulting in a wide range of outcomes from death and severe morbidity to more mild forms and subclinical carrier states.

We are studying these parasites and the host-parasite relationships from several complementary perspectives: How did they evolve? What are the genetic and environmental factors that determine infection outcomes and disease severity? How can we use our understanding of them to discover new and better treatments?

Currently our main focus is the pathogenesis of digestive forms of Chagas disease. We are using experimental models of T. cruzi infection to study how this parasite establishes and maintains a chronic reservoir in the GI tract and the associated impact on the enteric nervous system.

 

 

Selected Publications

Imaging the development of chronic Chagas disease after oral transmission.
Lewis, M.D. ; Francisco, A.F. ; Jayawardhana, S. ; Langston, H. ; Taylor, M.C. ; Kelly, J.M. ;
2018
Sci Rep
The midgut microbiota plays an essential role in sand fly vector competence for Leishmania major.
Louradour, I. ; Monteiro, C.C. ; Inbar, E. ; Ghosh, K. ; Merkhofer, R. ; Lawyer, P. ; Paun, A. ; Smelkinson, M. ; Secundino, N. ; Lewis, M. ; Erram, D. ; Zurek, L. ; Sacks, D. ;
2017
Cell Microbiol
Molecular Diversity of Trypanosoma cruzi Detected in the Vector Triatoma protracta from California, USA.
Shender, L.A. ; Lewis, M.D. ; Rejmanek, D. ; Mazet, J.A. ;
2016
PLoS Negl Trop Dis
Host and parasite genetics shape a link between Trypanosoma cruzi infection dynamics and chronic cardiomyopathy.
Lewis, M.D. ; Francisco, A.F. ; Taylor, M.C. ; Jayawardhana, S. ; Kelly, J.M. ;
2016
Cell Microbiol
Putting Infection Dynamics at the Heart of Chagas Disease.
Lewis, M.D. ; Kelly, J.M. ;
2016
Trends Parasitol
Genome and Phylogenetic Analyses of Trypanosoma evansi Reveal Extensive Similarity to T. brucei and Multiple Independent Origins for Dyskinetoplasty.
Carnes, J.; Anupama, A.; Balmer, O.; Jackson, A.; Lewis, M.; Brown, R.; Cestari, I.; Desquesnes, M.; Gendrin, C.; Hertz-Fowler, C.; Imamura, H.; Ivens, A.; Kořený, L.; Lai, D.H.; MacLeod, A.; McDermott, S.M.; Merritt, C.; Monnerat, S.; Moon, W.; Myler, P.; Phan, I.; Ramasamy, G.; Sivam, D.; Lun, Z.R.; Lukeš, J.; Stuart, K.; Schnaufer, A.;
2015
PLoS Negl Trop Dis
Bioluminescence imaging of chronic Trypanosoma cruzi infections reveals tissue-specific parasite dynamics and heart disease in the absence of locally persistent infection.
Lewis, M.D.; Fortes Francisco, A.; Taylor, M.C.; Burrell-Saward, H.; McLatchie, A.P.; Miles, M.A.; Kelly, J.M.;
2014
Cell Microbiol
Recent, Independent and Anthropogenic Origins of Trypanosoma cruzi Hybrids.
Lewis, M.D. ; Llewellyn, M.S. ; Yeo, M. ; Acosta, N. ; Gaunt, M.W. ; Miles, M.A. ;
2011
PLoS Negl Trop Dis
See all Dr Michael Lewis's Publications