Dr Michael Lewis


Assistant Professor

Rm 390

Keppel Street
United Kingdom


I am currently working on the role of the gut and its microbiota in experimental models of visceral leishmaniasis and Chagas disease. This project is supported by a Marie Curie International Outgoing Fellowship as part of which I recently spent two years in the laboratory of Dr. David Sacks at the National Institutes of Health in Bethesda, USA.

I previously completed my PhD and early post-doctoral work on the genetics and evolution of Trypanosoma cruzi in the Miles lab, also at LSHTM. I obtained a BSc in Genetics in 2002 and an MSc in Medical Molecular Microbiology in 2004, both from the University of Nottingham.


Faculty of Infectious and Tropical Diseases
Department of Pathogen Molecular Biology


I am involved in teaching across several of LSHTM's London-based MSc courses and I am a tutor on the MSc Infectious Diseases by distance learning programme.


Three of the most important neglected infectious diseases, Human African Trypanosomiasis, Chagas disease and leishmaniasis are caused by parasites from the protozoan order Trypanosomatida: Trypanosoma brucei, T. cruzi and Leishmania sp. respectively. These parasites are all able to establish long-term chronic infections in people resulting in a wide range of outcomes from death and severe morbidity to more mild forms and subclinical carrier states.

I am studying these parasites and the host-parasite relationships from several complementary perspectives: How did they evolve? What are the genetic and environmental factors that determine infection outcomes and disease severity? How can we use our understanding of them to discover new and better treatments?



Selected Publications

The midgut microbiota plays an essential role in sand fly vector competence for Leishmania major.
Louradour, I. ; Monteiro, C.C. ; Inbar, E. ; Ghosh, K. ; Merkhofer, R. ; Lawyer, P. ; Paun, A. ; Smelkinson, M. ; Secundino, N. ; Lewis, M. ; Erram, D. ; Zurek, L. ; Sacks, D. ;
Cell Microbiol
Molecular Diversity of Trypanosoma cruzi Detected in the Vector Triatoma protracta from California, USA.
Shender, L.A. ; Lewis, M.D. ; Rejmanek, D. ; Mazet, J.A. ;
PLoS Negl Trop Dis
Host and parasite genetics shape a link between Trypanosoma cruzi infection dynamics and chronic cardiomyopathy.
Lewis, M.D. ; Francisco, A.F. ; Taylor, M.C. ; Jayawardhana, S. ; Kelly, J.M. ;
Cell Microbiol
Putting Infection Dynamics at the Heart of Chagas Disease.
Lewis, M.D. ; Kelly, J.M. ;
Trends Parasitol
Genome and Phylogenetic Analyses of Trypanosoma evansi Reveal Extensive Similarity to T. brucei and Multiple Independent Origins for Dyskinetoplasty.
Carnes, J.; Anupama, A.; Balmer, O.; Jackson, A.; Lewis, M.; Brown, R.; Cestari, I.; Desquesnes, M.; Gendrin, C.; Hertz-Fowler, C.; Imamura, H.; Ivens, A.; Kořený, L.; Lai, D.H.; MacLeod, A.; McDermott, S.M.; Merritt, C.; Monnerat, S.; Moon, W.; Myler, P.; Phan, I.; Ramasamy, G.; Sivam, D.; Lun, Z.R.; Lukeš, J.; Stuart, K.; Schnaufer, A.;
PLoS Negl Trop Dis
The limited ability of posaconazole to cure both acute and chronic Trypanosoma cruzi infections revealed by highly sensitive in vivo imaging.
Fortes Francisco, A. ; Lewis, M.D. ; Jayawardhana, S. ; Taylor, M.C. ; Chatelain, E. ; Kelly, J.M. ;
Antimicrob Agents Chemother
Bioluminescence imaging of chronic Trypanosoma cruzi infections reveals tissue-specific parasite dynamics and heart disease in the absence of locally persistent infection.
Lewis, M.D.; Fortes Francisco, A.; Taylor, M.C.; Burrell-Saward, H.; McLatchie, A.P.; Miles, M.A.; Kelly, J.M.;
Cell Microbiol
Recent, Independent and Anthropogenic Origins of Trypanosoma cruzi Hybrids.
Lewis, M.D. ; Llewellyn, M.S. ; Yeo, M. ; Acosta, N. ; Gaunt, M.W. ; Miles, M.A. ;
PLoS Negl Trop Dis
See all Dr Michael Lewis's Publications