Dr James Lewis


Associate Professor
; co-Deputy Director of the Centre for Evaluation


Keppel Street
United Kingdom

+44 (0) 207 927 2921

I studied maths and applied statistics for my BA and MSc and then completed a PhD in the epidemiology of HIV in rural Zimbabwe at Imperial College London. I then moved to LSHTM to be based full-time in Johannesburg, South Africa for seven years at the Aurum Institute working on TB and HIV. I moved back to the School in July 2012, where I continue to work on TB projects in South Africa, China and Peru, as well as health systems strengthening studies in Zambia and Burkina Faso.


Faculty of Epidemiology and Population Health
Department of Infectious Disease Epidemiology


Centre for Evaluation
Statistical Methodology
Tuberculosis (TB) Centre


I am co-organiser of the Advanced Statistical Methods in Epidemiology module on the Distance Learning MSc in Epidemiology. I also teach on the face-to-face and distance learning modules on the Evaluation of Public Health Interventions. 


The primary focus of my research is the evaluation of large, cluster randomised trials in TB control and health systems strengthening. These investigate the impact of:

  • medication monitors on TB adherence in China;
  • a socioeconomic support package, delivered to TB affected families, on TB control in Lima, Peru;
  • household point-of-care CD4 testing and household delivered isoniazid and cotrimoxazole preventive therapy on linkage to HIV care and preventive therapy completion in TB affected households in South Africa;
  • a health systems strengthening intervention on child and adult mortality and health system coverage in Lusaka, Zambia;
  • an e-health solution to improve adherence to Integrated Management of Childhood Illnesses guidelines in Burkina Faso.
Research Area
Clinical trials
Complex interventions
Health systems
Public health
Quality improvement
Social and structural determinants of health
Impact evaluation
Mobile technologies
Implementation research
Randomised controlled trials
Disease and Health Conditions
Infectious disease
Burkina Faso
South Africa
East Asia & Pacific (all income levels)
Latin America & Caribbean (developing only)
Sub-Saharan Africa (all income levels)

Selected Publications

Stepped wedge randomised controlled trials: systematic review of studies published between 2010 and 2014.
Beard, E. ; Lewis, J.J. ; Copas, A. ; Davey, C. ; Osrin, D. ; Baio, G. ; Thompson, J.A. ; Fielding, K.L. ; Omar, R.Z. ; Ononge, S. ; Hargreaves, J. ; Prost, A. ;
Designing a stepped wedge trial: three main designs, carry-over effects and randomisation approaches.
Copas, A.J. ; Lewis, J.J. ; Thompson, J.A. ; Davey, C. ; Baio, G. ; Hargreaves, J.R. ;
Designing and implementing a socioeconomic intervention to enhance TB control: operational evidence from the CRESIPT project in Peru.
Wingfield, T. ; Boccia, D. ; Tovar, M.A. ; Huff, D. ; Montoya, R. ; Lewis, J.J. ; Gilman, R.H. ; Evans, C.A. ;
BMC Public Health
Effectiveness of Electronic Reminders to Improve Medication Adherence in Tuberculosis Patients: A Cluster-Randomised Trial.
Liu, X. ; Lewis, J.J. ; Zhang, H. ; Lu, W. ; Zhang, S. ; Zheng, G. ; Bai, L. ; Li, J. ; Li, X. ; Chen, H. ; Liu, M. ; Chen, R. ; Chi, J. ; Lu, J. ; Huan, S. ; Cheng, S. ; Wang, L. ; Jiang, S. ; Chin, D.P. ; Fielding, K.L. ;
PLoS Med
A trial of mass isoniazid preventive therapy for tuberculosis control.
Churchyard, G.J. ; Fielding, K.L. ; Lewis, J.J. ; Coetzee, L. ; Corbett, E.L. ; Godfrey-Faussett, P. ; Hayes, R.J. ; Chaisson, R.E. ; Grant, A.D. ; Thibela TB Study Team, . ;
N Engl J Med
Mortality associated with delays between clinic entry and ART initiation in resource-limited-settings: results of a transition-state model.
Hoffmann, C.J.; Lewis, J.J.; Dowdy, D.W.; Fielding, K.L.; Grant, A.D.; Martinson, N.A.; Churchyard, G.J.; Chaisson, R.E.;
J Acquir Immune Defic Syndr
Eligibility for isoniazid preventive therapy in South african gold mines.
Lewis, J.J. ; Fielding, K.L. ; Grant, A.D. ; Chihota, V.N. ; Popane, F. ; Luttig, M. ; Muller, D. ; Coetzee, L. ; Churchyard, G.J. ;
PLoS One
"Proof-of-concept" evaluation of an automated sputum smear microscopy system for tuberculosis diagnosis.
Lewis, J.J. ; Chihota, V.N. ; van der Meulen, M. ; Fourie, P.B. ; Fielding, K.L. ; Grant, A.D. ; Dorman, S.E. ; Churchyard, G.J. ;
PLoS One
See all Dr James Lewis's Publications