Professor Sinead Langan


of Clinical Epidemiology and Wellcome Senior Clinical Fellow


Keppel Street
United Kingdom

0207 9272680

I trained in Medicine at the Queen's University of Belfast and continue to work clinically at St John's Institute of Dermatology, Guy's and St Thomas' Hospital, providing clinical care for patients with chronic inflammatory skin diseases. I joined the School in 2011 having completed my PhD at the University of Nottingham and gained post-doctoral experience as a visiting scholar at the University of Pennsylvania, USA.
I am currently funded by a Wellcome Senior Clinical Fellowship in Science, having previously been an NIHR Clinician Scientist.
I am Associate Director for Health Data Research UK London ( I co-founded and co-Chair the REporting of studies Conducted using Observational Routinely collected Data (RECORD) initiative ( I also co-lead of the Electronic Health Records group ( at LSHTM. I am former Chair of the European Dermatoepidemiology Network Steering committee (


Faculty of Epidemiology and Population Health
Department of Non-communicable Disease Epidemiology


Centre for Global Chronic Conditions


I teach on a number of courses at the School, and I am former co-Course Organiser for the Certificate of Pharmacoepidemiology and Pharmacovigilance (PEPI).


I am a clinical epidemiologist with experience working on a wide range of important disease areas.
My research addresses two major areas:
1. Understanding the epidemiology of immune mediated inflammatory conditions in order to improve outcomes
2. Improving methodology for the conduct and reporting of research using routinely collected health data including electronic health records.

1. Understanding the epidemiology of immune mediated inflammatory conditions in order to improve outcomes
Immune mediated inflammatory conditions, including skin diseases, affect many sections of the population and tend to be chronic in nature. Despite their high frequency, the burden, outcomes and optimal treatments for inflammatory disorders are poorly understood.
My research addresses an important research gap: the causes, consequences and treatment of immune mediated inflammatory conditions, with a specific focus on skin diseases and improving outcomes for these conditions. Little is known about the epidemiology of skin diseases. My work focuses in particular on using the power of routine data sources to provide answers for important research questions. This research has been used to inform NHS and international policy.
  I lead a programme of work on atopic eczema in adults using a variety of data sources. This work is supported by a Wellcome Senior Clinical fellowship in Science. We have identified eczema phenotypes using longitudinal population-based data and are using a comprehensive approach to investigate if there are strong associations between eczema and major adverse health and social outcomes using large longitudinal population-based data. Recent key discoveries include the association between severe eczema and major cardiovascular outcomes. This cutting-edge body of work will make substantial contributions towards understanding eczema complexity and co-morbidity, as well as improving patient outcomes.
I have been leading a large national project (17 million people) focused on COVID-19 outcomes in people with immune mediated inflammatory diseases using OpenSAFELY (a new secure platform to facilitate analyses of UK electronic health record data). A principal aim of this work is to assess if targeted and standard immune modifying drugs in immune mediated inflammatory diseases are associated with increased adverse outcomes.

2. Improving methodology for the conduct and reporting of research using routinely collected health data including electronic health records.
I co-founded the REporting of studies Conducted using Observational Routinely collected Data (RECORD) initiative ( ) in 2012 in order to create reporting guidelines for studies undertaken using observational routinely-collected data. These guidelines are in widespread use and have been adopted by most of the leading journals. We are now expanding our efforts upstream to improve the methodology of studies undertaken using routinely-collected health data.

Additional activities
I am co-leading the flagship Coronavirus School Infection Survey in partnership with Office for National Statistics and Public Health England ( This national study (150 schools) was developed to assess coronavirus transmission in UK schools
I established a programme of research to understand indirect effects of the COVID-19 pandemic on NHS services (Lancet Dig Health 2021)

I led an LSHTM programme with Young Scientists (school students) on public trust using health data for research and an innovative Wellcome-funded public engagement programme on the effect of eczema on lives through art and theatre.


Research Area
Clinical databases
Health outcomes
Primary care
Public health
Systematic reviews
Electronic health records
Disease and Health Conditions
Chronic disease
Non-communicable diseases
Skin disease
United Kingdom
United States of America
European Union
North America
Sub-Saharan Africa (all income levels)

Selected Publications

Indirect acute effects of the COVID-19 pandemic on physical and mental health in the UK: a population-based study.
Mansfield KE; Mathur R; Tazare J; Henderson AD; Mulick AR; Carreira H; Matthews AA; Bidulka P; Gayle A; Forbes H
The Lancet. Digital health
Four childhood atopic dermatitis subtypes identified from trajectory and severity of disease and internally validated in a large UK birth cohort.
Mulick AR; Mansfield KE; Silverwood RJ; Budu-Aggrey A; Roberts A; Custovic A; Pearce N; Irvine AD; Smeeth L; Abuabara K
British journal of dermatology
Atopic eczema in adulthood and mortality: UK population-based cohort study, 1998-2016.
Silverwood RJ; Mansfield KE; Mulick A; Wong AYS; Schmidt SAJ; Roberts A; Smeeth L; Abuabara K; Langan SM
Journal of Allergy and Clinical Immunology
Atopic eczema and cancer: parallel cohort studies in England and Denmark
Mansfield K; Schmidt S; Darvalics B; Mulick A; Wong Y; Søresen HT; Smeeth L; Bhaskaran K; Dos Santos Silva I; Silverwood R
JAMA dermatology
La déclaration RECORD-PE (Reporting of Studies Conducted Using Observational Routinely Collected Health Data Statement for Pharmacoepdemiology) : directives pour la communication des études realisées à partir de données de santé observationelles collectées en routine en pharmacoépidémiologie.
Langan SM; Schmidt SAJ; Wing K; Ehrenstein V; Nicholls SG; Filion KB; Klungel O; Petersen I; Sørensen HT; Dixon WG
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
Atopic eczema and fracture risk in adults: A population-based cohort study.
Lowe KE; Mansfield KE; Delmestri A; Smeeth L; Roberts A; Abuabara K; Prieto-Alhambra D; Langan SM
Journal of Allergy and Clinical Immunology
The reporting of studies conducted using observational routinely collected health data statement for pharmacoepidemiology (RECORD-PE).
Langan SM; Schmidt SA; Wing K; Ehrenstein V; Nicholls SG; Filion KB; Klungel O; Petersen I; Sorensen HT; Dixon WG
BMJ (Clinical research ed.)
Severe and predominantly active atopic eczema in adulthood and long term risk of cardiovascular disease: population based cohort study.
Silverwood RJ; Forbes HJ; Abuabara K; Ascott A; Schmidt M; Schmidt SAJ; Smeeth L; Langan SM
BMJ (Clinical research ed)
See more Publications