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Professor Sinead Langan

FRCP MSc PhD

Professor
of Clinical Epidemiology and Wellcome Senior Clinical Fellow

Room
258f

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
0207 9272680

I trained in Medicine at the Queen's University of Belfast and continue to work clinically at St John's Institute of Dermatology, Guy's and St Thomas' Hospital. I joined the School in 2011 having completed my PhD at the University of Nottingham and gained post-doctoral experience as a visiting scholar at the University of Pennsylvania, USA.

I am currently funded by a Wellcome Senior Clinical Fellowship in Science.

I am Associate Director for Health Data Research UK London (www.hdruk.ac.uk). I co-founded and co-Chair the REporting of studies Conducted using Observational Routinely collected Data (RECORD) initiative (www.record-statement.org). I am former Chair of the European Dermatoepidemiology Network Steering committee (www.orgs.dermis.net/eden).

Affiliations

Department of Non-communicable Disease Epidemiology
Faculty of Epidemiology and Population Health

Centres

Centre for Global Chronic Conditions

Teaching

I teach on a number of courses at the School, and I am former co-Course Organiser for the Certificate of Pharmacoepidemiology and Pharmacovigilance (PEPI).

Research

My research addresses two major areas:

  1. The epidemiology of skin diseases
  2. Reporting of observational research undertaken using routinely collected data

1. The epidemiology of skin diseases

Skin disease affects many sections of the population. Despite their high frequency, the burden, outcomes and optimal treatments for skin diseases are poorly understood.

My research addresses an important research gap, the causes, consequences and treatment of skin disease. Little is known about the epidemiology of skin diseases. My work focuses in particular on using the power of routine data sources to provide answers for important research questions. This research has been used to inform NHS and international policy.

  I lead a programme of work on eczema using a variety of data sources. This work is supported by a Wellcome Senior Clinical fellowship in Science. We have identified eczema phenotypes using longitudinal population-based data and are using a comprehensive approach to investigate if there are strong associations between eczema and major adverse health and social outcomes using large longitudinal population-based data. Recent key discoveries include the association between severe eczema and major cardiovascular outcomes. This cutting-edge body of work will make substantial contributions towards understanding eczema complexity and improving patient outcomes.

https://www.lshtm.ac.uk/research/centres-projects-group/skindiseases

2.Reporting of observational research undertaken using routinely collected data

I co-founded the REporting of studies Conducted using Observational Routinely collected Data (RECORD) initiative (www.record-statement.org ) in 2012 in order to create reporting guidelines for studies undertaken using observational routinely-collected data. 

Additional activities

I am co-leading the Coronavirus School Infection Survey in partnership with Office for National Statistics and Public Health England. This national study (150 schools) was rapidly developed to assess coronavirus transmission in UK schools

I established a programme of research to rapidly understand indirect effects of the COVID-19 pandemic on NHS services (Lancet Dig Health 2021)

I led an LSHTM programme with Young Scientists (school students) on public trust using health data for research and an innovative Wellcome-funded public engagement programme on the effect of eczema on lives through art and theatre.

http://www.lshtm.ac.uk/eph/ncde/ehrresearchgroup/index.html

www.orgs.dermis.net/eden

www.record-statement.org

 

Research Area
Clinical databases
Health outcomes
Primary care
Public health
Systematic reviews
Vaccines
Electronic health records
Discipline
Epidemiology
Medicine
Disease and Health Conditions
Herpesviruses
Allergy
Asthma
Non-communicable diseases
Country
United Kingdom
Ireland
United States of America
Region
European Union
North America
World

Selected Publications

Indirect acute effects of the COVID-19 pandemic on physical and mental health in the UK: a population-based study.
Mansfield KE; Mathur R; Tazare J; Henderson AD; Mulick AR; Carreira H; Matthews AA; Bidulka P; Gayle A; Forbes H
2021
The Lancet. Digital health
Four childhood atopic dermatitis subtypes identified from trajectory and severity of disease and internally validated in a large UK birth cohort.
Mulick AR; Mansfield KE; Silverwood RJ; Buddu-Aggrey A; Roberts A; Custovic A; Pearce N; Irvine AD; Smeeth L; Abuabara K
2021
The British journal of dermatology
Atopic eczema in adulthood and mortality: UK population-based cohort study, 1998-2016.
Silverwood RJ; Mansfield KE; Mulick A; Wong AYS; Schmidt SAJ; Roberts A; Smeeth L; Abuabara K; Langan SM
2021
Journal of Allergy and Clinical Immunology
Atopic eczema and cancer: parallel cohort studies in England and Denmark
Mansfield K; Schmidt S; Darvalics B; Mulick A; Wong Y; Søresen HT; Smeeth L; Bhaskaran K; Dos Santos Silva I; Silverwood R
2020
JAMA dermatology
La déclaration RECORD-PE (Reporting of Studies Conducted Using Observational Routinely Collected Health Data Statement for Pharmacoepdemiology) : directives pour la communication des études realisées à partir de données de santé observationelles collectées en routine en pharmacoépidémiologie.
Langan SM; Schmidt SAJ; Wing K; Ehrenstein V; Nicholls SG; Filion KB; Klungel O; Petersen I; Sørensen HT; Dixon WG
2019
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
Atopic eczema and fracture risk in adults: A population-based cohort study.
Lowe KE; Mansfield KE; Delmestri A; Smeeth L; Roberts A; Abuabara K; Prieto-Alhambra D; Langan SM
2019
Journal of Allergy and Clinical Immunology
The reporting of studies conducted using observational routinely collected health data statement for pharmacoepidemiology (RECORD-PE).
Langan SM; Schmidt SA; Wing K; Ehrenstein V; Nicholls SG; Filion KB; Klungel O; Petersen I; Sorensen HT; Dixon WG
2018
BMJ (Clinical research ed.)
Severe and predominantly active atopic eczema in adulthood and long term risk of cardiovascular disease: population based cohort study.
Silverwood RJ; Forbes HJ; Abuabara K; Ascott A; Schmidt M; Schmidt SAJ; Smeeth L; Langan SM
2018
BMJ (Clinical research ed)
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