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Helen Kelly

PhD

Assistant Professor

Room
Room 309

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
+44 (0) 20 7927 2025

Fax.
+44 (0) 20 7927 2739

Since 2010, I coordinated an EU FP7 funded study called HARP (HPV in Africa Research Partnership) which was a multi-centre evaluation study of cervical cancer screening strategies, including HPV DNA based tests, for women living with HIV in Africa. 

As part of my PhD, I investigated risk factors for HPV and associated cervical lesions among women living with HIV in Burkina Faso and South Africa.  I also evaluated a DNA methylation assay for a human gene marker (EPB41L3) for the detection of high-grade cervical intraepithelial neoplasia (CIN2+). I also evaluated HPV genotype specific antibody responses over time according to HPV infection status.

I am currently involved in research aiming to summarise evidence on immunogenicity and efficacy against HPV infection and clinical outcomes of different HPV vaccine schedules.

Affiliations

Department of Clinical Research
Faculty of Infectious and Tropical Diseases

Teaching

I co-organise the module Control of Sexually Transmitted Infections and teach on the Vaccine Immunology module. I am a tutor on the module GCP, Ethics and Regulatory Affairs as part of the Distance Learning MSc in Clinical Trials.

Research

Research Area
Clinical trials
Diagnostics
Public health
Sexual health
Systematic reviews
Vaccines
Global Health
Implementation research
Reproductive health
Discipline
Genetic epidemiology
Epidemiology
Disease and Health Conditions
Syphilis
Cancer
HIV/AIDS
Infectious disease
Cervical cancer
Human papillomavirus (HPV)
Sexually transmitted infection
Country
Burkina Faso
Brazil
Tanzania
Uganda
South Africa
Zambia
Region
Latin America & Caribbean (all income levels)
Sub-Saharan Africa (developing only)

Selected Publications

Epidemiology of High-risk Human Papillomavirus and Cervical Lesions in African women living with HIV/AIDS: Effect of Anti-Retroviral Therapy.
Kelly, H.A. ; Sawadogo, B. ; Chikandiwa, A. ; Segondy, M. ; Gilham, C. ; Lompo, O. ; Omar, T. ; Didelot, M.N. ; Nagot, N. ; Meda, N. ; Weiss, H.A. ; Delany-Moretlwe, S. ; Mayaud, P. ; HARP Study Group, . ;
2017
AIDS
Associations of Human Papillomavirus (HPV) genotypes with high-grade cervical neoplasia (CIN2+) in a cohort of women living with HIV in Burkina Faso and South Africa.
Kelly, H.A. ; Ngou, J. ; Chikandiwa, A. ; Sawadogo, B. ; Gilham, C. ; Omar, T. ; Lompo, O. ; Doutre, S. ; Meda, N. ; Weiss, H.A. ; Delany-Moretlwe, S. ; Segondy, M. ; Mayaud, P. ; HARP Study Group, . ;
2017
PLoS One
Cervical intraepithelial neoplasia (CIN) in African women living with HIV: role and effect of rigorous histopathological review by a panel of pathologists in the HARP study endpoint determination.
Doutre, S. ; Omar, T. ; Goumbri-Lompo, O. ; Kelly, H. ; Clavero, O. ; Zan, S. ; Chikandiwa, A. ; Sawadogo, B. ; Delany-Moretlwe, S. ; Costes, V. ; Mayaud, P. ; Segondy, M. ; HARP Study Group, . ;
2017
J Clin Pathol
Association of antiretroviral therapy with high-risk human papillomavirus, cervical intraepithelial neoplasia, and invasive cervical cancer in women living with HIV: a systematic review and meta-analysis.
Kelly, H. ; Weiss, H.A. ; Benavente, Y. ; de Sanjose, S. ; Mayaud, P. ; ART and HPV Review Group, . ; COLLABORATORS;Qiao, Y.L. ; Feng, R.M. ; DeVuyst, H. ; Tenet, V. ; Jaquet, A. ; Konopnicki, D. ; Omar, T. ; Menezes, L. ; Moucheraud, C. ; Hoffman, R. ;
2017
Lancet HIV
Systematic reviews of point-of-care tests for the diagnosis of urogenital Chlamydia trachomatis infections.
Kelly, H. ; Coltart, C.E.M. ; Pant Pai, N. ; Klausner, J.D. ; Unemo, M. ; Toskin, I. ; Peeling, R.W. ;
2017
Sex Transm Infect
Performance of careHPV for detecting high-grade cervical intraepithelial neoplasia among women living with HIV-1 in Burkina Faso and South Africa: HARP study.
Segondy, M. ; Kelly, H. ; Magooa, M.P. ; Djigma, F. ; Ngou, J. ; Gilham, C. ; Omar, T. ; Goumbri-Lompo, O. ; Michelow, P. ; Doutre, S. ; Clavero, O. ; Chikandiwa, A. ; Sawadogo, B. ; Didelot, M.N. ; Costes, V. ; Méda, N. ; Delany-Moretlwe, S. ; Mayaud, P. ;
2016
Br J Cancer
Comparison of Analytical and Clinical Performances of the Digene HC2 HPV DNA Assay and the INNO-LiPA HPV Genotyping Assay for Detecting High-Risk HPV Infection and Cervical Neoplasia Among HIV-Positive African Women.
Ngou, J. ; Gilham, C. ; Omar, T. ; Goumbri-Lompo, O. ; Doutre, S. ; Michelow, P. ; Kelly, H. ; Didelot, M.N. ; Chikandiwa, A. ; Sawadogo, B. ; Delany-Moretlwe, S. ; Meda, N. ; Costes, V. ; Mayaud, P. ; Segondy, M. ;
2015
J Acquir Immune Defic Syndr
Comparison of CareHPV and Hybrid Capture 2 Assays for Detection of High-Risk HPV DNA in Cervical Samples from HIV-1-Infected African Women.
Ngou, J.; Magooa, M.P.; Gilham, C.; Djigma, F.; Didelot, M.N.; Kelly, H.; Yonli, A.; Sawadogo, B.; Lewis, D.A.; Delany-Moretlwe, S.; Mayaud, P.; Segondy, M.; HARP Study Group, .;
2013
J Clin Microbiol
See all Helen Kelly's Publications