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Professor Joe Jarvis

BSc MSc MBBS MRCP DTM&H PhD

Professor
of Tropical Medicine and International Health

Room
358

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
+267 76524122

I am an NIHR Global Health Research Professor, currently based full time in Gaborone, Botswana, where I work for the Botswana Harvard AIDS Institute Partnership. My main research interests are advanced HIV disease, opportunistic infections, cryptococcal meningitis and other CNS infections, and strategies to rapidly and safely initiate ART in individuals with low CD4 counts. In am the Chief Investigator for the AMBITION-cm trial examining new treatments for HIV-associated cryptococcal meningitis in Botswana, Zimbabwe, South Africa, Malawi, and Uganda, and recently worked as Research Director for the CDC Implementation Protocol of the Botswana Combination Prevention Project (BCPP). I am a member of the external review group for the WHO Guidelines for Managing Advanced HIV Disease and Rapid Initiation of Antiretroviral Therapy, and a guidelines development group member for WHO guidelines on preventing, diagnosing, and managing cryptococcal disease in HIV infected adults, adolescents and children. In addition to my research I work as an infectious diseases consultant in Botswana and at the Hospital for Tropical Diseases in London.

 

Affiliations

Department of Clinical Research
Faculty of Infectious and Tropical Diseases

Teaching

I am a member of the teaching faculty on the East African DTM&H course, jointly run by the London School of Hygiene and Tropical Medicine (LSHTM), Johns Hopkins University and the University of Washington, and based at African partner sites in Tanzania (Kilimanjaro Christian Medical College) and Uganda (Makerere University). I am module co-lead for the Tropical Medicine and parasitology week. I also lecture on the London based DTM&H, supervise summer projects for Tropical Medicine and International Health MSc students, and supervise PhD students based in Botswna and South Africa.  

Research

I hold a €10 million EDCTP / Wellcome Trust / MRC / DFID Joint Global Health Trials co-funded grant to run a multi-centre randomised trial investigating single-dose liposomal amphotericin treatment for HIV-associated cryptococcal meningitis. The trial consortium involves partners in Africa (University of Cape Town; University of Zimbabwe; Botswana Harvard Partnership; Malawi-Liverpool Wellcome Trust Centre, Blantyre and the University of North Carolina Project, Lilongwe, Malawi; and the Infectious Diseases Institute, Makerere University, Uganda) and Europe (St. George's University of London; University of Liverpool; Liverpool School of Tropical Medicine; and Institut Pasteur Paris). In addition to the clinical trial, the project includes PK/PD analyses, an economic evaluation, and numerous sub-studies, as well as a considerable training and capacity building component.

Building on the trial, my NIHR professorship funds translational studies aimed at improving understanding of the aetiology of meningitis in high HIV-prevalence settings, developing and testing novel diagnostics for central nervous system infections, and exploring host genetic susceptibility to cryptococcal meningitis.

 

Research Area
Clinical care
Clinical trials
Diagnostics
Economic evaluation
Human genetics
T-cell immunology
Global Health
Medicines
Pharmacokinetics
Randomised controlled trials
Discipline
Genomics
Epidemiology
Immunology
Medicine
Microbiology
Molecular biology
Pharmacology
Disease and Health Conditions
HIV/AIDS
Infectious disease
Meningitis
Emerging Infectious Disease
Country
Botswana
France
Malawi
Tanzania
Uganda
South Africa
Zimbabwe
Region
Sub-Saharan Africa (all income levels)

Selected Publications

HIV-associated cryptococcal meningitis: ongoing challenges and new opportunities.
Tenforde MW; Jarvis JN
2019
The Lancet. Infectious Diseases
Mortality in adult patients with culture-positive and culture-negative meningitis in the Botswana national meningitis survey: a prevalent cohort study.
Tenforde MW; Mokomane M; Leeme TB; Tlhako N; Tsholo K; Chebani T; Stephenson A; Hutton J; Mitchell HK; Patel RK
2019
The Lancet. Infectious diseases
Short-course High-dose Liposomal Amphotericin B for Human Immunodeficiency Virus-associated Cryptococcal Meningitis: A Phase 2 Randomized Controlled Trial.
Jarvis JN; Leeme TB; Molefi M; Chofle AA; Bidwell G; Tsholo K; Tlhako N; Mawoko N; Patel RKK; Tenforde MW
2018
Clinical infectious diseases
Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis.
Rajasingham R; Smith RM; Park BJ; Jarvis JN; Govender NP; Chiller TM; Denning DW; Loyse A; Boulware DR
2017
The Lancet infectious diseases
Advanced Human Immunodeficiency Virus Disease in Botswana Following Successful Antiretroviral Therapy Rollout: Incidence of and Temporal Trends in Cryptococcal Meningitis.
Tenforde MW; Mokomane M; Leeme T; Patel RKK; Lekwape N; Ramodimoosi C; Dube B; Williams EA; Mokobela KO; Tawanana E
2017
Clinical infectious diseases
Forgotten but not gone: HIV-associated cryptococcal meningitis.
Jarvis JN; Harrison TS
2016
The Lancet infectious diseases
Cryptococcal meningitis: epidemiology, immunology, diagnosis and therapy.
Williamson PR; Jarvis JN; Panackal AA; Fisher MC; Molloy SF; Loyse A; Harrison TS
2016
Nature reviews. Neurology
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