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Prof Joe Jarvis

Prof of Tropical Medicine&Intern Health

United Kingdom

I am an NIHR Global Health Research Professor, currently based between LSHTM and Gaborone, Botswana, where I work for the Botswana Harvard AIDS Institute Partnership. My main research interests are advanced HIV disease, opportunistic infections, cryptococcal meningitis and other CNS infections, and strategies to rapidly and safely initiate ART in individuals with low CD4 counts. I was the Chief Investigator for the AMBITION-cm trial examining new treatments for HIV-associated cryptococcal meningitis in Botswana, Zimbabwe, South Africa, Malawi, and Uganda, and recently worked as Research Director for the CDC Implementation Protocol of the Botswana Combination Prevention Project (BCPP). I hold an NIHR Global Health Research Professorship and lead an NIHR Global Health Group on HIV-asociated fungal infections. I am a member of the external review group for the WHO Guidelines for Managing Advanced HIV Disease and Rapid Initiation of Antiretroviral Therapy, and a guidelines development group member for WHO guidelines on preventing, diagnosing, and managing cryptococcal disease in HIV infected adults, adolescents and children. In addition to my research I work as an infectious diseases consultant in Botswana and at the Hospital for Tropical Diseases in London.

Affiliations

Department of Clinical Research
Faculty of Infectious and Tropical Diseases

Teaching

I am a member of the teaching faculty on the East African DTM&H course, jointly run by the London School of Hygiene and Tropical Medicine (LSHTM), Johns Hopkins University and the University of Washington, and based at African partner sites in Tanzania (Kilimanjaro Christian Medical College) and Uganda (Makerere University). I am module co-lead for the Tropical Medicine and parasitology week. I also lecture on the London based DTM&H, supervise summer projects for Tropical Medicine and International Health MSc students, and supervise PhD students based in Botswana and South Africa.

Research

I recently completed a €10 million EDCTP / Wellcome Trust / MRC / DFID Joint Global Health Trials co-funded project running a multi-centre randomised trial investigating single-dose liposomal amphotericin treatment for HIV-associated cryptococcal meningitis (the AMBITION-cm Trial). The trial consortium involved partners in Africa (University of Cape Town; University of Zimbabwe; Botswana Harvard Partnership; Malawi-Liverpool Wellcome Trust Centre, Blantyre and the University of North Carolina Project, Lilongwe, Malawi; and the Infectious Diseases Institute, Makerere University, Uganda) and Europe (St. George's University of London; University of Liverpool; Liverpool School of Tropical Medicine; and Institut Pasteur Paris). In addition to the clinical trial, the project included PK/PD analyses, an economic evaluation, and numerous sub-studies, as well as a considerable training and capacity building component. The findings were published in the NEJM in March 2022, and WHO guidelines were updated to include the new strategy as recommended first line treatment in April 2022.

Building on the trial, my NIHR professorship funds translational studies aimed at improving understanding of the aetiology of meningitis in high HIV-prevalence settings, developing and testing novel diagnostics for central nervous system infections, and exploring host genetic susceptibility to cryptococcal meningitis. A CDC collaborative award is supporting the roll-out of the AMBITION-cm regimen widely across Africa. And the NIHR Global Health Group, co-led with Professor Nelesh Govender at the NICD in Johannesburg, South Africa, is applying the lessons learnt through the AMBITION-cm trial to other HIV-associated fungal infections of public health importance including histoplasmosis, PCP, and talaromycosis.

Research Area
Clinical trials
Clinical research
Clinical drug trials
Clinical guidelines
Clinical medicine
Epidemiology
Immunology
Genomics
Diagnostics
Disease and Health Conditions
HIV/AIDS
Tropical diseases
Meningitis
Country
Botswana
Malawi
South Africa
Uganda
Vietnam
Zimbabwe
Guinea
Democratic Republic of the Congo
Mozambique
Region
Sub-Saharan Africa (all income levels)
East Asia & Pacific (developing only)

Selected Publications

Advanced HIV as a Neglected Disease.
Ford, N; Ehrenkranz, P; JARVIS, J;
2024
The New England journal of medicine
Translating evidence into global impact: lessons for HIV research and policy development from the AMBITION trial.
JARVIS, JN; Chou, R; Harrison, TS; LAWRENCE, DS; Muthoga, C; Mupeli, K; Meya, DB; Mwandumba, HC; Kanyama, C; Meintjes, G; Leeme, TB; Ndhlovu, CE; Beattie, P; Sued, O; Pérez Casas, C; Makanga, M; Ford, N;
2023
The Lancet Global health
Cost-effectiveness of single, high-dose, liposomal amphotericin regimen for HIV-associated cryptococcal meningitis in five countries in sub-Saharan Africa: an economic analysis of the AMBITION-cm trial.
LAWRENCE, DS; Muthoga, C; Meya, DB; Tugume, L; Williams, D; Rajasingham, R; Boulware, DR; Mwandumba, HC; Moyo, M; Dziwani, EN; Maheswaran, H; Kanyama, C; Hosseinipour, MC; Chawinga, C; Meintjes, G; Schutz, C; Comins, K; Bango, F; Muzoora, C; Jjunju, S; Nuwagira, E; Mosepele, M; Leeme, T; Ndhlovu, CE; Hlupeni, A; ... AMBITION Study Group,
2022
The Lancet Global Health
Single-Dose Liposomal Amphotericin B Treatment for Cryptococcal Meningitis.
JARVIS, JN; LAWRENCE, DS; Meya, DB; Kagimu, E; Kasibante, J; Mpoza, E; Rutakingirwa, MK; Ssebambulidde, K; Tugume, L; Rhein, J; Boulware, DR; Mwandumba, HC; Moyo, M; Mzinganjira, H; Kanyama, C; Hosseinipour, MC; Chawinga, C; Meintjes, G; Schutz, C; Comins, K; Singh, A; Muzoora, C; Jjunju, S; Nuwagira, E; Mosepele, M; ... Ambition Study Group,
2022
New England Journal of Medicine
Rapid antiretroviral therapy initiation in the Botswana Combination Prevention Project: a quasi-experimental before and after study.
Lebelonyane, R; Bachanas, P; Block, L; Ussery, F; Abrams, W; Roland, M; Theu, J; Kapanda, M; Matambo, S; Lockman, S; Gaolathe, T; Makhema, J; Moore, J; JARVIS, JN;
2020
LANCET HIV
HIV-associated cryptococcal meningitis: ongoing challenges and new opportunities.
Tenforde, MW; JARVIS, JN;
2019
The Lancet. Infectious diseases
Mortality in adult patients with culture-positive and culture-negative meningitis in the Botswana national meningitis survey: a prevalent cohort study.
Tenforde, MW; Mokomane, M; Leeme, TB; Tlhako, N; Tsholo, K; Chebani, T; Stephenson, A; Hutton, J; Mitchell, HK; Patel, RK; Hurt, WJ; Pilatwe, T; Masupe, T; Molefi, M; Guthrie, BL; Farquhar, C; Mine, M; JARVIS, JN;
2019
The Lancet. Infectious diseases
Short-course High-dose Liposomal Amphotericin B for Human Immunodeficiency Virus-associated Cryptococcal Meningitis: A Phase 2 Randomized Controlled Trial.
JARVIS, JN; Leeme, TB; Molefi, M; Chofle, AA; Bidwell, G; Tsholo, K; Tlhako, N; Mawoko, N; Patel, RK K; Tenforde, MW; Muthoga, C; Bisson, GP; Kidola, J; Changalucha, J; LAWRENCE, D; Jaffar, S; Hope, W; Molloy, SL F; Harrison, TS;
2018
Clinical infectious diseases
Advanced Human Immunodeficiency Virus Disease in Botswana Following Successful Antiretroviral Therapy Rollout: Incidence of and Temporal Trends in Cryptococcal Meningitis.
Tenforde, MW; Mokomane, M; Leeme, T; Patel, RK K; Lekwape, N; Ramodimoosi, C; Dube, B; Williams, EA; Mokobela, KO; Tawanana, E; Pilatwe, T; Hurt, WJ; Mitchell, H; Banda, DL; Stone, H; Molefi, M; Mokgacha, K; Phillips, H; Mullan, PC; Steenhoff, AP; Mashalla, Y; Mine, M; JARVIS, JN;
2017
Clinical infectious diseases
Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis.
Rajasingham, R; Smith, RM; Park, BJ; JARVIS, JN; Govender, NP; Chiller, TM; Denning, DW; Loyse, A; Boulware, DR;
2017
The Lancet infectious diseases
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