Dr Rein Houben


Associate Professor
in Infectious Disease Epidemiology


Keppel Street
United Kingdom

+44(0)20 7927 2956

I came to the School in 2006, working primarily on the molecular epidemiology of Tuberculosis. After spending 3 years working on field studies in North Malawi, I moved back to London in 2012 to work in TB modelling, and joined the LSHTM TB modelling group. Since 2014 I have led the development and implementation of the TIME model. My current focus is to examine TB Natural History using modelling tools as part of an ERC Starting Grant.


Faculty of Epidemiology and Population Health
Department of Infectious Disease Epidemiology


Centre for the Mathematical Modelling of Infectious Diseases (CMMID)
TB Centre


I have taught on a wide variety of courses in the In House and Distance Learning MSc Epidemiology. Currently I am a module co-organiser for EP202: Statistical Methods in Epidemiology, and departmental Research Degree Coordinator for IDE. I also run the Virtual Ethics Committee in EPM103: Practical Epidemiology.


I currently (co-)supervise 4 PhD students, working on TB natural history, patient catastrophic costs, TB diagnostic algorithms and the male excess in TB burden.


My main research focus is creating mathematical models for academic, policy decisions and capacity building purposes. I lead the development and implementation of TIME, a widely used TB modelling tool. My ERC grant work aims to improve our understanding of TB natural history, with a particular focus on the mechanism and treatment of latent TB infection as well as socio-economic determinants of TB.  

Research Area
Mathematical modelling
Disease and Health Conditions
Euro area
South Asia
Sub-Saharan Africa (developing only)
Sub-Saharan Africa (all income levels)

Selected Publications

Spotting the old foe-revisiting the case definition for TB.
Houben RMGJ; Esmail H; Emery JC; Joslyn LR; McQuaid CF; Menzies NA; Sanz J; Shrestha S; White RG; Yang C
Lancet Respiratory Medicine
The impact of social protection and poverty elimination on global tuberculosis incidence: a statistical modelling analysis of Sustainable Development Goal 1.
Carter DJ; Glaziou P; Lönnroth K; Siroka A; Floyd K; Weil D; Raviglione M; Houben RMGJ; Boccia D
The Lancet Global health
Tuberculosis transmission during the subclinical period: could unrelated cough play a part?
Esmail H; Dodd PJ; Houben RMGJ
The lancet Respiratory medicine
Systematic neglect of men as a key population in tuberculosis.
Horton KC; White RG; Houben RMGJ
Tuberculosis (Edinburgh, Scotland)
What if They Don't Have Tuberculosis? The Consequences and Trade-offs Involved in False-positive Diagnoses of Tuberculosis.
Houben RMGJ; Lalli M; Kranzer K; Menzies NA; Schumacher SG; Dowdy DW
Clinical infectious diseases
TIME Impact - a new user-friendly tuberculosis (TB) model to inform TB policy decisions.
Houben RMGJ; Lalli M; Sumner T; Hamilton M; Pedrazzoli D; Bonsu F; Hippner P; Pillay Y; Kimerling M; Ahmedov S
BMC medicine
Feasibility of achieving the 2025 WHO global tuberculosis targets in South Africa, China, and India: a combined analysis of 11 mathematical models.
Houben RMGJ; Menzies NA; Sumner T; Huynh GH; Arinaminpathy N; Goldhaber-Fiebert JD; Lin H-H; Wu C-Y; Mandal S; Pandey S
The Lancet Global health
Ability of preventive therapy to cure latent Mycobacterium tuberculosis infection in HIV-infected individuals in high-burden settings.
Houben RMGJ; Sumner T; Grant AD; White RG
Proceedings of the National Academy of Sciences of the United States of America
The effect of diabetes and undernutrition trends on reaching 2035 global tuberculosis targets.
Odone A; Houben RMGJ; White RG; Lönnroth K
The lancet Diabetes & endocrinology
See more Publications