Dr Rein Houben


Associate Professor
in Infectious Disease Epidemiology


Keppel Street
United Kingdom

+44(0)20 7927 2956

I came to the School in 2006, working primarily on the molecular epidemiology of Tuberculosis. After spending 3 years working on field studies in North Malawi, I moved back to London in 2012 to work in TB modelling, and joined the LSHTM TB modelling group. Since 2014 I have led the development and implementation of the TIME model. My current focus is to examine TB Natural History using modelling tools as part of an ERC Starting Grant.


Department of Infectious Disease Epidemiology
Faculty of Epidemiology and Population Health


Mathematical Modelling of Infectious Diseases
Tuberculosis (TB) Centre


I have taught on a wide variety of courses in the In House and Distance Learning MSc Epidemiology. Currently I am a module co-organiser for EP202: Statistical Methods in Epidemiology, and departmental Research Degree Coordinator for IDE. I also run the Virtual Ethics Committee in EPM103: Practical Epidemiology


My main research focus is creating mathematical models for academic, policy decisions and capacity building purposes. I lead the development and implementation of TIME, a widely used TB modelling tool. My ERC grant work aims to improve our understanding of TB natural history, with a particular focus on the mechanism and treatment of latent TB infection as well as socio-economic determinants of TB.  

Research Area
Mathematical modelling
Disease and Health Conditions
Euro area
South Asia
Sub-Saharan Africa (developing only)
Sub-Saharan Africa (all income levels)

Selected Publications

The impact of social protection and poverty elimination on global tuberculosis incidence: a statistical modelling analysis of Sustainable Development Goal 1.
Carter, D.J. ; Glaziou, P. ; Lönnroth, K. ; Siroka, A. ; Floyd, K. ; Weil, D. ; Raviglione, M. ; Houben, R.M.G.J. ; Boccia, D. ;
Lancet Glob Health
Tuberculosis transmission during the subclinical period: could unrelated cough play a part?
Esmail, H. ; Dodd, P.J. ; Houben, R.M.G.J. ;
Lancet Respir Med
What if they don't have tuberculosis? The consequences and trade-offs involved in false-positive diagnoses of tuberculosis.
Houben, R.M.G.J. ; Lalli, M. ; Kranzer, K. ; Menzies, N.A. ; Schumacher, S.G. ; Dowdy, D.W. ;
Clin Infect Dis
TIME Impact - a new user-friendly tuberculosis (TB) model to inform TB policy decisions.
Houben, R.M. ; Lalli, M. ; Sumner, T. ; Hamilton, M. ; Pedrazzoli, D. ; Bonsu, F. ; Hippner, P. ; Pillay, Y. ; Kimerling, M. ; Ahmedov, S. ; Pretorius, C. ; White, R.G. ;
Feasibility of achieving the 2025 WHO global tuberculosis targets in South Africa, China, and India: a combined analysis of 11 mathematical models.
Houben, R.M. ; Menzies, N.A. ; Sumner, T. ; Huynh, G.H. ; Arinaminpathy, N. ; Goldhaber-Fiebert, J.D. ; Lin, H.H. ; Wu, C.Y. ; Mandal, S. ; Pandey, S. ; Suen, S.C. ; Bendavid, E. ; Azman, A.S. ; Dowdy, D.W. ; Bacaër, N. ; Rhines, A.S. ; Feldman, M.W. ; Handel, A. ; Whalen, C.C. ; Chang, S.T. ; Wagner, B.G. ; Eckhoff, P.A. ; Trauer, J.M. ; Denholm, J.T. ; McBryde, E.S. ; Cohen, T. ; Salomon, J.A. ; Pretorius, C. ; Lalli, M. ; Eaton, J.W. ; Boccia, D. ; Hosseini, M. ; Gomez, G.B. ; Sahu, S. ; Daniels, C. ; Ditiu, L. ; Chin, D.P. ; Wang, L. ; Chadha, V.K. ; Rade, K. ; Dewan, P. ; Hippner, P. ; Charalambous, S. ; Grant, A.D. ; Churchyard, G. ; Pillay, Y. ; Mametja, L.D. ; Kimerling, M.E. ; Vassall, A. ; White, R.G. ;
Lancet Glob Health
The effect of diabetes and undernutrition trends on reaching 2035 global tuberculosis targets.
Odone, A. ; Houben, R.M. ; White, R.G. ; Lönnroth, K. ;
Lancet Diabetes Endocrinol
See all Dr Rein Houben's Publications