Dr Rein Houben


of Infectious Disease Epidemiology


Keppel Street
United Kingdom

+44(0)20 7927 2956

I came to the School in 2006, working primarily on the molecular epidemiology of Tuberculosis. After spending 3 years working on field studies in North Malawi, I moved back to London in 2012 to work in TB modelling, and joined the LSHTM TB modelling group. Since 2014 I have led the development and implementation of the TIME model. My current focus is to examine TB Natural History using modelling tools as part of an ERC Starting Grant.


Department of Infectious Disease Epidemiology
Faculty of Epidemiology and Population Health


Centre for Mathematical Modelling of Infectious Diseases (CMMID)
TB Centre


I have taught on a wide variety of courses in the In House and Distance Learning MSc Epidemiology. Currently I am a module co-organiser for EP202: Statistical Methods in Epidemiology, and departmental Research Degree Coordinator for IDE. I also run the Virtual Ethics Committee in EPM103: Practical Epidemiology.


I currently (co-)supervise 4 PhD students, working on TB natural history, patient catastrophic costs, TB diagnostic algorithms and the male excess in TB burden.


My main research focus is creating mathematical models for academic, policy decisions and capacity building purposes. I lead the development and implementation of TIME, a widely used TB modelling tool. My ERC grant work aims to improve our understanding of TB natural history, with a particular focus on the mechanism and treatment of latent TB infection as well as socio-economic determinants of TB.  

Research Area
Mathematical modelling
Disease and Health Conditions
Euro area
South Asia
Sub-Saharan Africa (developing only)
Sub-Saharan Africa (all income levels)

Selected Publications

Does Ghana's National Health Insurance Scheme provide financial protection to tuberculosis patients and their households?
Pedrazzoli D; Carter DJ; Borghi J; Laokri S; Boccia D; Houben RM
Social Science and Medicine
The natural history of TB disease-a synthesis of data to quantify progression and regression across the spectrum
Richards AS; Sossen B; Emery JC; Horton KC; Heinsohn T; Frascella B; Balzarini F; Oradini-Alacreu A; Hacker B; Odone A
Self-clearance of Mycobacterium tuberculosis infection: implications for lifetime risk and population at-risk of tuberculosis disease.
Emery JC; Richards AS; Dale KD; McQuaid CF; White RG; Denholm JT; Houben RMGJ
Proceedings of the Royal Society B: Biological Sciences
The contribution of asymptomatic SARS-CoV-2 infections to transmission on the Diamond Princess cruise ship.
Emery JC; Russell TW; Liu Y; Hellewell J; Pearson CA; CMMID COVID-19 Working Group; Knight GM; Eggo RM; Kucharski AJ; Funk S
Subclinical Tuberculosis Disease-A Review and Analysis of Prevalence Surveys to Inform Definitions, Burden, Associations, and Screening Methodology.
Frascella B; Richards AS; Sossen B; Emery JC; Odone A; Law I; Onozaki I; Esmail H; Houben RMGJ
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Post-tuberculosis mortality and morbidity: valuing the hidden epidemic.
Quaife M; Houben RMGJ; Allwood B; Cohen T; Coussens AK; Harries AD; van Kampen S; Marx FM; Sweeney S; Wallis RS
The Lancet Respiratory Medicine
Spotting the old foe-revisiting the case definition for TB.
Houben RMGJ; Esmail H; Emery JC; Joslyn LR; McQuaid CF; Menzies NA; Sanz J; Shrestha S; White RG; Yang C
Lancet Respiratory Medicine
Global burden of latent multidrug-resistant tuberculosis: trends and estimates based on mathematical modelling.
Knight GM; McQuaid CF; Dodd PJ; Houben RMGJ
Lancet Infectious Diseases
The impact of social protection and poverty elimination on global tuberculosis incidence: a statistical modelling analysis of Sustainable Development Goal 1.
Carter DJ; Glaziou P; Lönnroth K; Siroka A; Floyd K; Weil D; Raviglione M; Houben RMGJ; Boccia D
The Lancet Global health
Tuberculosis transmission during the subclinical period: could unrelated cough play a part?
Esmail H; Dodd PJ; Houben RMGJ
The lancet Respiratory medicine
Systematic neglect of men as a key population in tuberculosis.
Horton KC; White RG; Houben RMGJ
Tuberculosis (Edinburgh, Scotland)
Feasibility of achieving the 2025 WHO global tuberculosis targets in South Africa, China, and India: a combined analysis of 11 mathematical models.
Houben RMGJ; Menzies NA; Sumner T; Huynh GH; Arinaminpathy N; Goldhaber-Fiebert JD; Lin H-H; Wu C-Y; Mandal S; Pandey S
The Lancet Global health
Ability of preventive therapy to cure latent Mycobacterium tuberculosis infection in HIV-infected individuals in high-burden settings.
Houben RMGJ; Sumner T; Grant AD; White RG
Proceedings of the National Academy of Sciences of the United States of America
See more Publications