in Malaria & Diagnostics
Since 2003, my professional focus has been clinical and implementation research on malaria diagnostic strategies and management of febrile patients in malaria-endemic areas. These interests have led to current work on fever etiology and antimicrobial resistance. I head the Clinical & Veterinary Sciences pillar of LSHTM’s Antimicrobial Resistance Centre.
Previous affiliations include the Foundation for Innovative New Diagnostics (FIND) in Uganda and Switzerland, and the Makerere University – University of California, San Francisco malaria research collaboration in Uganda.
My educational history includes degrees in anthropology (BA with Honors, University of Iowa), medicine (MD, Columbia College of Physicians & Surgeons, New York), and coursework in public health (University of California, Berkeley), as well as clinical training in internal medicine (Columbia-Presbyterian Medical Center, New York) and infectious diseases (University of California, San Francisco).
I teach on LSHTM's Epidemiology & Control of Malaria module; the Epidemiology & Control of Communicable Disease module; and the Infectious Disease Research Design, Management & Analysis course. I also mentor Master's and PhD students.
I have served as investigator and coordinator for numerous field evaluations of point-of-care diagnostic tests in children, adults and pregnant women, and for evaluations of fever case management strategies. I have been based primarily in Uganda, and have also conducted collaborative research in other African and southeast Asian countries.
In 2018 we began FIEBRE (Febrile Illness Evaluation in a Broad Range of Endemicities), a prospective study of fever etiologies and antibiotic resistance in inpatients and outpatients of all ages at multiple sites in Africa and Asia.
Other current projects include synthesis of research results from ACT Consortium studies of malaria rapid diagnostic test (mRDT) implementation in various endemic settings; investigation of pfhrp2/3 gene deletions in P. falciparum samples from Africa and Asia; and a collaborative effort to map data on non-malaria febrile illness.
My work includes collaboration with other academic researchers as well as with scientists and public health experts from the WHO, non-profit organizations, funding agencies, and diagnostics developers.
- Thomson R, Beshir KB, Cunningham J, Baiden F, Bharmal J, Bruxvoort KJ, Maiteki-Sebuguzi C, Owusu-Agyei S, Staedke SG, Hopkins H. pfhrp2 and pfhrp3 gene deletions that affect malaria rapid diagnostic tests for Plasmodium falciparum: analysis of archived blood samples from three African countries. J Infect Dis, Jun 2019.
- Bruxvoort KJ, Leurent B, Chandler CIR, [ACT Consortium RDTs in Context Working Group], Schellenberg D, Hopkins H. The impact of introducing malaria rapid diagnostic tests on fever case management: A synthesis of ten studies from the ACT Consortium. AJTMH 97(4):1170-1179, Oct 2017.
- Hopkins H, Bruxvoort KJ, Cairns M, [ACT Consortium RDTs in Context Working Group], Staedke SG, Whitty CJM. The impact of introducing malaria rapid diagnostic tests on antibiotic prescribing: a nine-site analysis in public and private health care settings. BMJ 356:j1054, April 2017.
- Kyabayinze DJ, Zongo I, Cunningham J, Gatton M, Angutoko P, Ategeka J, Compaoré YD, Muehlenbachs A, Mulondo J, Nakalembe M, Somé FA, Ouattara A, Rouamba N, Ouédraogo JB, Hopkins H, Bell D. HRP2 and pLDH-based rapid diagnostic tests, expert microscopy, and PCR for detection of malaria infection during pregnancy and at delivery in areas of varied transmission: a prospective cohort study in Burkina Faso and Uganda. PLoS One 11(7):e0156954, Jul 2016.
- Mbabazi P, Hopkins H, Osilo E, Kalungu M, Byakika-Kibwika P, Kamya MR. Accuracy of two malaria rapid diagnostic tests (RDTs) for initial diagnosis and treatment monitoring in a high transmission setting in Uganda. AJTMH 92(3):530-6, Mar 2015.
- Odaga J, Sinclair D, Lokong JA, Donegan S, Hopkins H, Garner P. Rapid diagnostic tests versus clinical diagnosis for managing people with fever in malaria endemic settings. Cochrane Database Syst Rev 17;4:CD008998, Apr 2014.
- Hopkins H, “Diagnosis of malaria” section, UpToDate, Inc., Wolters Kluwer Health; maintained since Aug 2013.
- Hopkins H, González IJ, Polley SD, Angutoko P, Ategeka J, Asiimwe C, Agaba B, Kyabayinze DJ, Sutherland CJ, Perkins MD, Bell D. Highly sensitive detection of malaria parasitemia in a malaria-endemic setting: performance of a new loop-mediated isothermal amplification kit in a remote clinic in Uganda. J Infect Dis 208(4):645-52, Aug 2013.
- Hopkins H, Asiimwe C, Bell D. Access to antimalarial therapy: accurate diagnosis is essential to achieving long term goals. BMJ 339:b2606, Jul 2009.
- Hopkins H, Bebell L, Kambale W, Dokomajilar C, Rosenthal PJ, Dorsey G. Rapid diagnostic tests for malaria at sites of varied transmission intensity in Uganda. J Infect Dis 197:510-8, Feb 2008.