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Dr Emma Harding-Esch

BA(Hons) MPhil MSc PhD AFHEA

Associate Professor

Room
309

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
020 7612 7982

I am an epidemiologist, with a focus on neglected tropical diseases (primarily trachoma) and sexually transmitted infections (STIs). 

I obtained both my MSc (Control of Infectious Diseases) and PhD ("Trachoma control and elimination: Field studies in The Gambia and Senegal") from LSHTM, and led the field studies for the Partnership for the Rapid Elimination of Trachoma (PRET) trial in The Gambia. I also have experience of infectious disease surveillance, having been the Senior Enhanced Surveillance Scientist for CJD at Public Health England, and then a Principal Scientist in PHE's HIV/STI department. I was Senior Trials Coordinator for the eSTI2 Consortium, led by St George's, University of London, and subsequently the Programme Manager and Epidemiology Lead for the Applied Diagnostic Research and Evaluation Unit (ADREU), where I conducted several diagnostic evaluations to assess the performance, clinical and public health impacts of novel diagnostic technologies for STIs.

I returned to LSHTM in November 2017 as an Associate Professor and Chief Scientist for Tropical Data (www.tropicaldata.org), supporting national programmes to collect scientifically robust and standardised neglected tropical disease (NTD) prevalence data, allowing interventions for disease elimination to be targeted and prioritised. Through this role, I support research to principally help improve NTD survey and diagnostic methods. I also continue to be involved in STI-related research.

I represent Tropical Data as an observer of the International Coalition for Trachoma Control (ICTC) and am an observer of the Trachoma Expert Committee. I am a member of the ICTC "Hard to reach populations" Task Team, the NNN "Conflict and Humanitarian Emergency" working group, and the NNN "WASH" working group. I am also co-chair of the WHO NTD Diagnostic Technical Advisory Group (DTAG) cross-cutting sub-group on surveillance. I am co-director of LSHTM's STI Research Interest Group (https://www.lshtm.ac.uk/research/centres-projects-groups/stirig), Bristol Health Partners Sexual Health Improvement Programme (https://www.bristolhealthpartners.org.uk/health-integration-teams/sexua…), and LSHTM's WHO Collaborating Centre for STIs (https://www.lshtm.ac.uk/research/centres-projects-groups/whocc-sti).

Affiliations

Faculty of Infectious and Tropical Diseases
Department of Clinical Research

Centres

Antimicrobial Resistance Centre (AMR)

Teaching

I am Co-Module Organiser for the Distance Learning module: Control of Infectious Diseases (IDM104), and a Lead Educator for the Eliminating Trachoma MOOC (https://www.futurelearn.com/courses/eliminating-trachoma)

I also lecture on trachoma and mapping on several MSc modules, am a personal tutor for the Control of Infectious Diseases MSc, and supervise MSc summer projects.

I am an Associate Fellow of the Higher Education Academy. 

Research

My research interests are focused on the epidemiology of neglected tropical diseases (NTDs), with a particular focus on trachoma, to inform the achievement and maintenance of disease elimination. This includes working with health ministries whose trachoma prevalence surveys have been supported by the Global Trachoma Mapping Project (GTMP) and Tropical Data, to explore questions relating to what factors are associated with achievement of elimination criteria, and development of methodologies for post-elimination validation surveillance. 

I also have a Sexually Transmitted Infection (STI) epidemiology research focus, and have a particular interest in diagnostics. I am a member of the British Association for Sexual Health and HIV (BASHH) and its Bacterial Special Interest Group (BSIG, https://www.bashh.org/bashh-groups/special-interest-groups/bacterial/).

I am interested in exploring the commonalities between ocular and genital C. trachomatis, including the impact of mass drug administration on disease prevalence and antimicrobial resistance. I am a member of LSHTM's AMR Centre.

I supervise research degree students, currently:

- Clara Burgert (https://www.lshtm.ac.uk/aboutus/people/burgert.clara): Spatial analysis and modelling to support trachoma elimination and surveillance

- Becca Handley (https://www.lshtm.ac.uk/aboutus/people/handley.rebecca): Improving diagnostics for yaws eradication

- Kristen Renneker: How can alternative indicators be used to measure the prevalence of trachoma post-validation of elimination in a way that guides programme decision-making? 

- Katja Siling: Improving STI testing access and surveillance in North Rhine-Westphalia state, Germany 

I am interested in supervising doctoral students working on:

- The diagnosis, epidemiology and elimination of trachoma (and other neglected tropical diseases), including for post-elimination validation surveillance.

- The epidemiology of sexually transmitted infections (STIs), evaluation of diagnostics for STIs and their public health impact.

Research Area
Clinical care
Diagnostics
Drug resistance
Economic evaluation
Health services research
Sexual health
Surveillance
Disease control
Global Health
Mixed methods
Mobile technologies
Implementation research
Discipline
Health economics
Molecular epidemiology
Epidemiology
GIS/Spatial analysis
Operational research
Social Sciences
Opthalmology
Disease and Health Conditions
CJD
Infectious disease
Sexually transmitted disease
Trachoma
Blindness
Neglected Tropical Diseases (NTDs)
Sexually transmitted infection
Tropical diseases
Yaws
Region
World

Selected Publications

Model-based geostatistics enables more precise estimates of neglected tropical-disease prevalence in elimination settings: mapping trachoma prevalence in Ethiopia.
Amoah B; Fronterre C; Johnson O; Dejene M; Seife F; Negussu N; Bakhtiari A; Harding-Esch EM; Giorgi E; Solomon AW
2021
International Journal of Epidemiology
Lessons from the Field: Integrated survey methodologies for neglected tropical diseases.
Harding-Esch EM; Brady MA; Angeles CAC; Fleming FM; Martin DL; McPherson S; Hurtado HM; Nesemann JM; Nwobi BC; Scholte RGC
2021
Transactions of the Royal Society of Tropical Medicine and Hygiene
High prevalence of coinfection of azithromycin-resistant Mycoplasma genitalium with other STIs: a prospective observational study of London-based symptomatic and STI-contact clinic attendees.
Broad CE; Furegato M; Harrison MA; Pond MJ; Tan N; Okala S; Fuller SS; Harding-Esch EM; Sadiq ST
2020
Sexually Transmitted Infections
Mass drug administration with azithromycin for trachoma elimination and the population structure of Streptococcus pneumoniae in the nasopharynx.
Gladstone RA; Bojang E; Hart J; Harding-Esch EM; Mabey D; Sillah A; Bailey RL; Burr SE; Roca A; Bentley SD
2020
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
Antimicrobial Resistance in Gonorrhea: Diagnostics to the Rescue.
Marks M; Harding-Esch E
2020
Clinical Infectious Diseases
The Importance of Failure: How Doing Impact Surveys That Fail Saves Trachoma Programs Money.
Solomon AW; Hooper PJ; Bangert M; Mwingira UJ; Bakhtiari A; Brady MA; Fitzpatrick C; Jones I; Kabona G; Kello AB
2020
American Journal of Tropical Medicine and Hygiene
Antibiotics for trachoma.
Evans JR; Solomon AW; Kumar R; Perez Á; Singh BP; Srivastava RM; Harding-Esch E
2019
The Cochrane database of systematic reviews
Impact of a single round of mass drug administration with azithromycin on active trachoma and ocular Chlamydia trachomatis prevalence and circulating strains in The Gambia and Senegal.
Harding-Esch EM; Holland MJ; Schémann J-F; Sillah A; Sarr B; Christerson L; Pickering H; Molina-Gonzalez S; Sarr I; Andreasen AA
2019
Parasites & vectors
Impact of mass drug administration of azithromycin for trachoma elimination on prevalence and azithromycin resistance of genital Mycoplasma genitalium infection.
Harrison MA; Harding-Esch EM; Marks M; Pond MJ; Butcher R; Solomon AW; Zhou L; Tan N; Nori AV; Kako H
2019
Sexually Transmitted Infections
A 30-Min Nucleic Acid Amplification Point-of-Care Test for Genital Chlamydia trachomatis Infection in Women: A Prospective, Multi-center Study of Diagnostic Accuracy.
Harding-Esch EM; Cousins EC; Chow S-LC; Phillips LT; Hall CL; Cooper N; Fuller SS; Nori AV; Patel R; Thomas-William S
2018
EBioMedicine
Diagnostic accuracy of a prototype rapid chlamydia and gonorrhoea recombinase polymerase amplification assay: a multicentre cross-sectional preclinical evaluation.
Harding-Esch EM; Fuller SS; Chow S-LC; Nori AV; Harrison MA; Parker M; Piepenburg O; Forrest MS; Brooks DG; Patel R
2018
Clinical microbiology and infection
'Test n Treat' (TnT): a cluster randomized feasibility trial of on-site rapid Chlamydia trachomatis tests and treatment in ethnically diverse, sexually active teenagers attending technical colleges.
Oakeshott P; Kerry-Barnard S; Fleming C; Phillips R; Drennan VM; Adams EJ; Majewska W; Harding-Esch EM; Cousins EC; Planche T
2018
Clinical Microbiology and Infection
Costs of testing for ocular Chlamydia trachomatis infection compared to mass drug administration for trachoma in the Gambia: application of results from the PRET study.
Harding-Esch E; Jofre-Bonet M; Dhanjal JK; Burr S; Edwards T; Holland M; Sillah A; West S; Lietman T; Keenan J
2015
PLoS neglected tropical diseases
Mass treatment with azithromycin for trachoma: when is one round enough? Results from the PRET Trial in the Gambia.
Harding-Esch EM; Sillah A; Edwards T; Burr SE; Hart JD; Joof H; Laye M; Makalo P; Manjang A; Molina S
2013
PLoS neglected tropical diseases
Diagnostic accuracy of a prototype point-of-care test for ocular Chlamydia trachomatis under field conditions in The Gambia and Senegal.
Harding-Esch EM; Holland MJ; Schémann J-F; Molina S; Sarr I; Andreasen AA; Roberts CH; Sillah A; Sarr B; Harding EF
2011
PLoS neglected tropical diseases
Two doses of azithromycin to eliminate trachoma in a Tanzanian community.
Solomon AW; Harding-Esch E; Alexander NDE; Aguirre A; Holland MJ; Bailey RL; Foster A; Mabey DCW; Massae PA; Courtright P
2008
The New England journal of medicine
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