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Dr Emma Harding-Esch

BA(Hons) MPhil MSc PhD AFHEA

Associate Professor

Room
309

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
020 7612 7982

I am an epidemiologist, with a focus on neglected tropical diseases (primarily trachoma) and sexually transmitted infections (STIs). 

I obtained both my MSc (Control of Infectious Diseases) and PhD ("Trachoma control and elimination: Field studies in The Gambia and Senegal") from LSHTM, and led the field studies for the Partnership for the Rapid Elimination of Trachoma (PRET) trial in The Gambia. I also have experience of infectious disease surveillance, having been the Senior Enhanced Surveillance Scientist for CJD at Public Health England, and then a Principal Scientist in PHE's HIV/STI department. I was Senior Trials Coordinator for the eSTI2 Consortium, led by St George's, University of London, and subsequently the Programme Manager and Epidemiology Lead for the Applied Diagnostic Research and Evaluation Unit (ADREU), where I conducted several diagnostic evaluations to assess the performance, clinical and public health impacts of novel diagnostic technologies for STIs.

I returned to LSHTM in November 2017 as an Associate Professor and Chief Scientist for Tropical Data (www.tropicaldata.org), supporting national programmes to collect scientifically robust and standardised neglected tropical disease prevalence data, allowing interventions for disease elimination to be targeted and prioritised. Through this role, I support research to principally help improve NTD survey and diagnostic methods. I also continue to be involved in STI-related research.

Affiliations

Department of Clinical Research
Faculty of Infectious and Tropical Diseases

Centres

Antimicrobial Resistance Centre (AMR)

Teaching

I am Co-Module Organiser for the Distance Learning module: Control of Infectious Diseases (IDM104), and a Lead Educator for the Eliminating Trachoma MOOC (https://www.futurelearn.com/courses/eliminating-trachoma)

I also lecture on trachoma and mapping on several MSc modules, am a facilitator on the Control of Sexually Transmitted Infections module, am a personal tutor for the Control of Infectious Diseases MSc, and supervise MSc summer projects.

I am an Associate Fellow of the Higher Education Academy. 

Research

My research interests are focused on the epidemiology of neglected tropical diseases (NTDs), with a particular focus on trachoma, to inform the achievement and maintenance of disease elimination. This includes working with health ministries whose trachoma prevalence surveys have been supported by the Global Trachoma Mapping Project (GTMP) and Tropical Data, to explore questions relating to what factors are associated with achievement of elimination criteria, and development of methodologies for post-elimination validation surveillance.

I also have a Sexually Transmitted Infection (STI) epidemiology research focus, and have a particular interest in diagnostics. I recently worked on the ECDC-funded project: "Novel testing technologies, strategies and approaches for testing populations at risk of sexually transmitted infections: a systematic review protocol to inform prevention and control in EU/EEA countries". I am co-director of LSHTM's STI Research Interest Group (-: CLEANED :- https://www.lshtm.ac.uk/research/centres-projects-groups/stirig -: CLEANED :-), and co-director of LSHTM's WHO Collaborating Centre for Sexually Transmitted Infections (-: CLEANED :- https://www.lshtm.ac.uk/research/centres-projects-groups/whocc-sti -: CLEANED :-).

I am interested in exploring the commonalities between ocular and genital C. trachomatis, including the impact of mass drug administration on disease prevalence and antimicrobial resistance. I am a member of LSHTM's AMR Centre.

I supervise research degree students, covering the following research topics: modelling trachoma epidemiology and survey methodologies to achieve elimination; assessing the real-life accuracy of a new diagnostic test in yaws-endemic areas.

I am interested in supervising doctoral students working on:

- The diagnosis, epidemiology and elimination of trachoma (and other neglected tropical diseases), including for post-elimination validation surveillance.

- The epidemiology of sexually transmitted infections (STIs), evaluation of diagnostics for STIs and their public health impact.

Research Area
Clinical care
Diagnostics
Drug resistance
Economic evaluation
Health services research
Sexual health
Surveillance
Disease control
Global Health
Mixed methods
Mobile technologies
Implementation research
Discipline
Health economics
Molecular epidemiology
Epidemiology
GIS/Spatial analysis
Operational research
Social Sciences
Opthalmology
Disease and Health Conditions
CJD
Infectious disease
Sexually transmitted disease
Trachoma
Blindness
Neglected Tropical Diseases (NTDs)
Sexually transmitted infection
Tropical diseases
Region
World

Selected Publications

High prevalence of coinfection of azithromycin-resistant Mycoplasma genitalium with other STIs: a prospective observational study of London-based symptomatic and STI-contact clinic attendees.
Broad CE; Furegato M; Harrison MA; Pond MJ; Tan N; Okala S; Fuller SS; Harding-Esch EM; Sadiq ST
2020
Sexually Transmitted Infections
Mass drug administration with azithromycin for trachoma elimination and the population structure of Streptococcus pneumoniae in the nasopharynx.
Gladstone RA; Bojang E; Hart J; Harding-Esch EM; Mabey D; Sillah A; Bailey RL; Burr SE; Roca A; Bentley SD
2020
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
Antimicrobial Resistance in Gonorrhea: Diagnostics to the Rescue.
Marks M; Harding-Esch E
2020
Clinical Infectious Diseases
The Importance of Failure: How Doing Impact Surveys That Fail Saves Trachoma Programs Money
Solomon AW; Hooper PJ; Bangert M; Mwingira UJ; Bakhtiari A; Brady MA; Fitzpatrick C; Jones I; Kabona G; Kello AB
2020
American Journal of Tropical Medicine and Hygiene
Antibiotics for trachoma.
Evans JR; Solomon AW; Kumar R; Perez Á; Singh BP; Srivastava RM; Harding-Esch E
2019
The Cochrane database of systematic reviews
Impact of a single round of mass drug administration with azithromycin on active trachoma and ocular Chlamydia trachomatis prevalence and circulating strains in The Gambia and Senegal.
Harding-Esch EM; Holland MJ; Schémann J-F; Sillah A; Sarr B; Christerson L; Pickering H; Molina-Gonzalez S; Sarr I; Andreasen AA
2019
Parasites & vectors
Impact of mass drug administration of azithromycin for trachoma elimination on prevalence and azithromycin resistance of genital Mycoplasma genitalium infection.
Harrison MA; Harding-Esch EM; Marks M; Pond MJ; Butcher R; Solomon AW; Zhou L; Tan N; Nori AV; Kako H
2019
Sexually Transmitted Infections
A 30-Min Nucleic Acid Amplification Point-of-Care Test for Genital Chlamydia trachomatis Infection in Women: A Prospective, Multi-center Study of Diagnostic Accuracy.
Harding-Esch EM; Cousins EC; Chow S-LC; Phillips LT; Hall CL; Cooper N; Fuller SS; Nori AV; Patel R; Thomas-William S
2018
EBioMedicine
Diagnostic accuracy of a prototype rapid chlamydia and gonorrhoea recombinase polymerase amplification assay: a multicentre cross-sectional preclinical evaluation.
Harding-Esch EM; Fuller SS; Chow S-LC; Nori AV; Harrison MA; Parker M; Piepenburg O; Forrest MS; Brooks DG; Patel R
2018
Clinical microbiology and infection
'Test n Treat' (TnT): a cluster randomized feasibility trial of on-site rapid Chlamydia trachomatis tests and treatment in ethnically diverse, sexually active teenagers attending technical colleges.
Oakeshott P; Kerry-Barnard S; Fleming C; Phillips R; Drennan VM; Adams EJ; Majewska W; Harding-Esch EM; Cousins EC; Planche T
2018
Clinical Microbiology and Infection
Costs of testing for ocular Chlamydia trachomatis infection compared to mass drug administration for trachoma in the Gambia: application of results from the PRET study.
Harding-Esch E; Jofre-Bonet M; Dhanjal JK; Burr S; Edwards T; Holland M; Sillah A; West S; Lietman T; Keenan J
2015
PLoS neglected tropical diseases
Mass treatment with azithromycin for trachoma: when is one round enough? Results from the PRET Trial in the Gambia.
Harding-Esch EM; Sillah A; Edwards T; Burr SE; Hart JD; Joof H; Laye M; Makalo P; Manjang A; Molina S
2013
PLoS neglected tropical diseases
Diagnostic accuracy of a prototype point-of-care test for ocular Chlamydia trachomatis under field conditions in The Gambia and Senegal.
Harding-Esch EM; Holland MJ; Schémann J-F; Molina S; Sarr I; Andreasen AA; Roberts CH; Sillah A; Sarr B; Harding EF
2011
PLoS neglected tropical diseases
Two doses of azithromycin to eliminate trachoma in a Tanzanian community.
Solomon AW; Harding-Esch E; Alexander NDE; Aguirre A; Holland MJ; Bailey RL; Foster A; Mabey DCW; Massae PA; Courtright P
2008
The New England journal of medicine
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