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Professor Heiner Grosskurth

MD PhD DTMH

Professor
of Epidemiology and International Health

Mwanza Intervention Trials Unit (MITU)
National Institute for Medical Research (NIMR)
Mwanza
Tanzania

Tel.
++255 28 2500019

After training in clinical medicine in Germany in the 1970ies, Heiner Grosskurth worked in various hospitals in Germany and in primary health care programmes in Peru, Sudan and Cameroon until he joined the School in 1991. He obtained a doctorate in internal medicine from the University of Kiel, a diploma in tropical medicine from the Bernard Nocht Institute in Hamburg, a consultant specialist degree in family medicine from the College of Physicians of North Rhine-Westfalia and a PhD in epidemiology from LSHTM.

From 1991 – 1995, Heiner was the director of the STD/HIV Intervention and Research Programme Mwanza, Tanzania, a collaboration between the School and the African Medical and Research Foundation (AMREF), and established AMREF’s HIV programme in the lake zone of Tanzania. From 1996 to 2001 he was based at LSHTM in London, continuing work on STIs and HIV infection. From 2001 to 2003 he headed the emerging HIV research programme of the Population Council in India, on secondment from LSHTM.

From 2003 to 2010, he was the director of the MRC Uganda Research Unit, then a collaborative institution of the MRC UK and the Uganda Virus Research Institute (UVRI) and one of the School’s overseas collaborative sites. Since 2011, he has been based at the Mwanza Intervention Trials Unit (MITU) in Tanzania, working with Saidi Kapiga on a research collaboration between the National Institute of Medical Research (NIMR) and LSHTM. He serves on steering and advisory committees of several research programmes in East Africa and is a founding member of the Lake Victoria Consortium for Health Research that aims to improve the health of populations residing in fishing communities in Uganda, Kenya and Tanzania.

Affiliations

Department of Infectious Disease Epidemiology
Faculty of Epidemiology and Population Health

Centres

Centre for Evaluation
Centre for Global Chronic Conditions

Teaching

Heiner teaches on study module 3198 ‘Applying Public Health Principles in Developing Countries’, jointly with Daniel Chandramohan, Jayne Webster and Silke Fernandes. He contributes to the School’s distance learning programme on infectious disease epidemiology. He was Chair of the Board of Examiners for the MSc Control of Infectious Diseases, and was responsible for setting up the School’s first study module on ‘Primary Health Care’. He also provides input to the NIMR/MITU based short course in research methods annualy held in Mwanza.

Research

Since joining LSHTM in 1991, Heiner Grosskurth’s main research interest has been in HIV/STI epidemiology and the clinical management of HIV/STI in sub-Saharan Africa. More recently, he expanded his work to include chronic non-communicable diseases (NCDs). - As director of the STD/HIV Research and Intervention Programme Mwanza he coordinated a trial that demonstrated that improvements of STI control services can reduce HIV incidence at the population level. He contributed to a subsequent trial on the effects of a school-based intervention to improve adolescent sexual and reproductive health, also conducted in Mwanza Region.

With colleagues from the MRC Uganda Researach Unit he investigated the dynamics of HIV infection in a general ruralpopulation cohort, the natural history of HIV infection in a rural African environment, and the feasibility of antiretroviral therapy (ART) provision in rural areas in the early days of ART introduction in Africa. He was co-PI of the Entebbe/Uganda based component  of the multi-centre DART trial that showed how ART care can be effectively provided in resource limited settings based on clinical rather than routine laboratory based monitoring. Jointly with colleagues from the School and from Uganda he demonstrated that ART care can also be effectively delivered through home-based care with the help of trained supervised lay workers. - He was Co-PI of a Ugandan trial to investigate the effect of stopping cotrimoxazole prophylaxis among HIV infected patients on long-term ART.

Currently, Heiner is co-investigator of research projects in Uganda and Tanzania to investigate (i) the epidemiology of non-communicable diseases (NCDs) and strategies to improve the effectiveness of health services in controlling NCDs. He is also involved in studies on the epidemiology of alcohol use (AU) and AU disorders among young people, on HIV infection, STIs and other health problems in fishing populations from Lake Victoria, on the epidemiology of helminth infections and on strategies to control WASH-related infections.

Research Area
Clinical trials
Complex interventions
Health services research
Primary care
Public health
Sanitation
Sexual health
Adolescent health
Alcohol
Health workers
Behaviour change
Disease control
Impact evaluation
Mixed methods
Randomised controlled trials
Reproductive health
Discipline
Epidemiology
Medicine
Operational research
Disease and Health Conditions
HIV/AIDS
Non-communicable diseases
Sexually transmitted infection
Country
India
Kenya
Tanzania
Uganda
Region
Least developed countries: UN classification
Sub-Saharan Africa (all income levels)

Selected Publications

Prevalence of high blood pressure and associated factors among adolescents and young people in Tanzania and Uganda
Nsanya MK; Kavishe BB; Katende D; Mosha N; Hansen C; Nsubuga RN; Munderi P; Grosskurth H; Kapiga S
2019
Journal of Clinical Hypertension
Experiences of capacity strengthening in sanitation and hygiene research in Africa and Asia: the SHARE Research Consortium
Torondel B; Balls E; Chisenga CC; Kumwenda S; Okello E; Simiyu S; Morse T; Smith K; Mumma J; Banzi J
2019
Health Research Policy and Systems
Safety and Immunogenicity of a 2-Dose Heterologous Vaccination Regimen With Ad26.ZEBOV and MVA-BN-Filo Ebola Vaccines: 12-Month Data From a Phase 1 Randomized Clinical Trial in Uganda and Tanzania
Anywaine Z; Whitworth H; Kaleebu P; Praygod G; Shukarev G; Manno D; Kapiga S; Grosskurth H; Kalluvya S; Bockstal V
2019
The Journal of infectious diseases
Effect of Stopping Cotrimoxazole Preventive Therapy on Microbial Translocation and Inflammatory Markers Among Human Immunodeficiency Virus-Infected Ugandan Adults on Antiretroviral Therapy: The COSTOP Trial Immunology Substudy.
Kyosiimire-Lugemwa J; Anywaine Z; Abaasa A; Levin J; Gombe B; Musinguzi K; Kaleebu P; Grosskurth H; Munderi P; Pala P
2019
The Journal of infectious diseases
Discontinuing cotrimoxazole preventive therapy in HIV-infected adults who are stable on antiretroviral treatment in Uganda (COSTOP): A randomised placebo controlled trial.
Anywaine Z; Levin J; Kasirye R; Lutaakome JK; Abaasa A; Nunn A; Grosskurth H; Munderi P; COSTOP research team
2018
PloS one
The validity of an area-based method to estimate the size of hard-to-reach populations using satellite images: the example of fishing populations of Lake Victoria.
Nash S; Tittle V; Abaasa A; Sanya RE; Asiki G; Hansen CH; Grosskurth H; Kapiga S; Grundy C; Lake Victoria Consortium for Health Research
2018
Emerging themes in epidemiology
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