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Dr Martin Goodier

BSc, D.Phil

Assistant Professor
Immunology

Room
238a

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
020 7927 7934

Dr Martin Goodier is an Assistant Professor in Immunology with a career focus on the immunology of infection in humans, including malaria, HIV-1 and HCMV. He has over 15 year’s research experience in human natural killer (NK) cell biology and infection. Dr Goodier’s research focusses on the impact of genetic and environmental factors on the functional differentiation of natural killer cells in children and adults. His research findings demonstrate important geographical differences in NK cell function in UK and African settings and the influence of regional genetic differences and exposure to human cytomegalovirus. Dr Goodier’s recent work unravels the relationship between acquired immune responses and the activation of NK cells after vaccination and the generation of memory-like NK cells after seasonal influenza and DTPiP vaccinations. As a member of the EBOVAC consortium, he is currently investigating the potential of EBOLA vaccine to promote NK cell responses in clinical trials.

Affiliations

Department of Immunology and Infection
Faculty of Infectious and Tropical Diseases

Centres

Vaccine Centre

Research

 

 

Research Area
Innate immunity
Vaccines
Viruses
Discipline
Immunology
Disease and Health Conditions
Herpesviruses
HIV/AIDS
Malaria
Influenza
Country
United Kingdom
Gambia, The
Senegal
Region
European Union
Sub-Saharan Africa (developing only)

Selected Publications

Enhancement of cytokine-driven NK cell IFN-γ production after vaccination of HCMV infected Africans.
Darboe, A. ; Danso, E. ; Clarke, E. ; Umesi, A. ; Touray, E. ; Wegmuller, R. ; Moore, S.E. ; Riley, E.M. ; Goodier, M.R. ;
2017
Eur J Immunol
Influenza Vaccination Generates Cytokine-Induced Memory-like NK Cells: Impact of Human Cytomegalovirus Infection.
Goodier, M.R.; Rodriguez-Galan, A.; Lusa, C.; Nielsen, C.M.; Darboe, A.; Moldoveanu, A.L.; White, M.J.; Behrens, R.; Riley, E.M.;
2016
J Immunol
Differential frequency of NKG2C/KLRC2 deletion in distinct African populations and susceptibility to Trachoma: a new method for imputation of KLRC2 genotypes from SNP genotyping data.
Goncalves, A.; Makalo, P.; Joof, H.; Burr, S.; Ramadhani, A.; Massae, P.; Malisa, A.; Mtuy, T.; Derrick, T.; Last, A.R.; Nabicassa, M.; Cassama, E.; Houghton, J.; Palmer, C.D.; Pickering, H.; Burton, M.J.; Mabey, D.C.; Bailey, R.L.; Goodier, M.R.; Holland, M.J.; Roberts, C.H.;
2016
Hum Genet
Sustained Immune Complex-Mediated Reduction in CD16 Expression after Vaccination Regulates NK Cell Function.
Goodier, M.R.; Lusa, C.; Sherratt, S.; Rodriguez-Galan, A.; Behrens, R.; Riley, E.M.;
2016
Front Immunol
Impaired NK Cell Responses to Pertussis and H1N1 Influenza Vaccine Antigens in Human Cytomegalovirus-Infected Individuals.
Nielsen, C.M.; White, M.J.; Bottomley, C.; Lusa, C.; Rodríguez-Galán, A.; Turner, S.E.; Goodier, M.R.; Riley, E.M.;
2015
J Immunol
Differential activation of CD57-defined natural killer cell subsets during recall responses to vaccine antigens.
White, M.J. ; Nielsen, C.M. ; McGregor, R.H. ; Riley, E.H. ; Goodier, M.R. ;
2014
Immunology
Rapid natural killer cell differentiation in a population with near universal human cytomegalovirus infection is attenuated by NKG2C deletions.
Goodier, M.R.; White, M.J.; Darboe, A.; Nielsen, C.M.; Goncalves, A.; Bottomley, C.; Moore, S.E.; Riley, E.M.;
2014
Blood
See all Dr Martin Goodier's Publications