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Mr Thomas Gachie

Research Assist. in Medical Stats. & Epi

United Kingdom

Bio

I am a statistical/epidemiologist working mainly on the epidemiology and control of infectious diseases in low and middle income countries (LMICs). Since 2019, I have been affiliated with the London school of hygiene and tropical medicines (LSHTM).

I have a Bachelors of science degree in Applied Statistics from Maseno University in Kenya (2013). I was awarded the ISEG postgraduate training fellowship in Medical Statistics at LSHTM (2018) followed by a one-year placement at Zambart (Zambia). My work at Zambart was primarily centred around the analysis of TB and HIV data from cluster randomized trials. I was also heavily involved in the TB reduction through expanded ART and screening (TREATS) prevalence survey within the TREATS project.

Before commencing my masters, I was involved in the use of spatial and spatiotemporal methodology in habitat suitability mapping and disease prevalence mapping projects.

Affiliations

Department of Infectious Disease Epidemiology and International Health
Faculty of Epidemiology and Population Health

Teaching

Tutor in the Distance Learning Advanced Statistical Methods in Epidemiology Module (EPM304)

Research

My research interests are on the use of causal inference methods to generate real world evidence from real world data. I am particularly, but not exclusively, interested in methods bridging the worlds of causal inference and machine learning, and the worlds of causal inference and spatial statistics.

Currently, I am undertaking an NIHR funded pre-doctoral fellowship where I am focusing on the use of causal inference and machine learning to investigate the causal effect of being HIV-positive and on antiretroviral therapy (ART), compared with being HIV-negative, on the risk of having prevalent TB-disease.

Beyond my research endeavors, I am deeply committed to enhancing the biostatistics capacity of both individuals and institutions in LMICs. To advance this goal, I hold the role of the Zambian research co-investigator in the MRC International Statistics and Epidemiology Partnership (ISEP). Across 6 institutions in Sub-Saharan Africa (SSA), ISEP’s primary mission is to define and implement a sustainable strategy aimed at expanding capacity for applied medical statistics.

Research Area
Epidemiology
GIS/Spatial analysis
Randomised controlled trials
Applied statistics (medical)
Disease and Health Conditions
Tuberculosis
HIV/AIDS
Malnutrition
Country
Zambia
South Africa
Region
Sub-Saharan Africa (all income levels)

Selected Publications

Evaluation of COVID-19 antigen rapid diagnostic tests for self-testing in Lesotho and Zambia
Bresser, M; Erhardt, RM; Shanaube, K; Simwinga, M; Mahlatsi, PA; Belus, J; Schaap, A; Amstutz, A; GACHIE, T; Glass, TR; Kangololo, B; 'Mota, J; Floyd, S; Katende, B; Klinkenberg, E; AYLES, H; Reither, K; RUPEREZ, M;
2024
PloS One
Tuberculosis prevalence after 4 years of population-wide systematic TB symptom screening and universal testing and treatment for HIV in the HPTN 071 (PopART) community-randomised trial in Zambia and South Africa: A cross-sectional survey (TREATS).
Klinkenberg, E; FLOYD, S; Shanaube, K; Mureithi, L; GACHIE, T; De Haas, P; Kosloff, B; Dodd, PJ; RUPEREZ, M; Wapamesa, C; Burnett, JM; Kalisvaart, N; Kasese, N; Vermaak, R; SCHAAP, A; Fidler, S; HAYES, R; AYLES, H; TREATS study team,;
2023
PLoS medicine
Use of point-of-care C-reactive protein testing for screening of tuberculosis in the community in high-burden settings: a prospective, cross-sectional study in Zambia and South Africa.
RUPEREZ, M; Shanaube, K; Mureithi, L; Wapamesa, C; Burnett, MJ; Kosloff, B; De Haas, P; HAYES, R; Fidler, S; GACHIE, T; SCHAAP, A; FLOYD, S; Klinkenberg, E; AYLES, H; TREATS study team,;
2023
The Lancet. Global health
Depressive symptoms and HIV risk behaviours among adolescents enrolled in the HPTN071 (PopART) trial in Zambia and South Africa.
Shanaube, K; GACHIE, T; Hoddinott, G; SCHAAP, A; FLOYD, S; Mainga, T; Bond, V; HAYES, R; Fidler, S; AYLES, H; HPTN071 (PopART) Study Team,;
2022
PloS One
Optimising Xpert-Ultra and culture testing to reliably measure tuberculosis prevalence in the community: findings from surveys in Zambia and South Africa.
FLOYD, S; Klinkenberg, E; De Haas, P; Kosloff, B; GACHIE, T; Dodd, PJ; RUPEREZ, M; Wapamesa, C; Burnett, MJ; Kalisvaart, N; Vermaak, R; Mainga, T; SCHAAP, A; Fidler, S; Mureithi, L; Shanaube, K; HAYES, R; AYLES, H; TREATS study team,;
2022
BMJ Open
Correction to: Insaka: mobile phone support groups for adolescent pregnant women living with HIV.
Simpson, N; Kydd, A; PHIRI, M; Mbewe, M; Sigande, L; GACHIE, T; Ngobeni, M; Monese, T; Figerova, Z; Schlesinger, H; BOND, V; Belemu, S; Simwinga, M; SCHAAP, A; Biriotti, M; Fidler, S; AYLES, H;
2021
BMC Pregnancy and Childbirth
Insaka: mobile phone support groups for adolescent pregnant women living with HIV.
Simpson, N; Kydd, A; PHIRI, M; Mbewe, M; Sigande, L; GACHIE, T; Ngobeni, M; Monese, T; Figerova, Z; Schlesinger, H; BOND, V; Belemu, S; Simwinga, M; SCHAAP, A; Biriotti, M; Fidler, S; AYLES, H;
2021
BMC pregnancy and childbirth
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