Professor Chris Frost

BA MA DipStat (Cantab)

of Medical Statistics


Keppel Street
United Kingdom

+44 (0) 207 9272242

I joined LSHTM in 1992, having previously worked at the Department of Environmental & Preventive Medicine, St. Bartholomew’s Medical College, London on a range of clinical trials and epidemiological projects.

Prior to working at St. Bartholomew's Medical College I studied at Pembroke College Cambridge for a degree in Mathematics and the Diploma in Mathematical Statistics.


Department of Medical Statistics
Faculty of Epidemiology and Population Health


Centre for Statistical Methodology


I currently teach 12 sessions on the Generalised Linear Models module (2462), which forms part of the MSc. in Medical Statistics.

I am a member of the MSc. in Medical Statistics Exam Board at LSHTM.

Throughout my time at LSHTM I have had a major involvement with the MSc. in Medical Statistics, being course organiser (twice) and admissions tutor as well as the roles listed above.


My research combines methodological research interests with the conduct of collaborative research studies. Over the past twenty years a large component of this research has been in neurology, with a particular focus on Dementia, Huntington’s Disease (HD) and Multiple Sclerosis (MS). This work includes involvement with the design, conduct and statistical analysis of randomised controlled clinical trials, including a phase II trial in secondary progressive MS (MS-STAT) that provided statistically significant evidence that statins slow both the rate of whole-brain atrophy and the clinical progression of the disease. A large phase III trial of statins in secondary progressive MS (MS-STAT2), funded by the NIHR, is currently in progress.

From a methodological standpoint I have a particular interest in clinical trial design, addressing questions such as quantifying the advantages of extending follow-up, introducing interim visits and introducing novel design features such as run-in periods into trials in neurology.

I also collaborate with colleagues at the Department of Psychiatry at Oxford University, on a program of research involving the conduct and analysis of randomised trials and cohort studies. One such study is the HOME study, an NIHR funded randomised controlled trial investigating whether a programme of Proactive Psychological Medicine can reduce the time older people admitted to hospital spend there.

My research is not limited to the UK. I have been involved in the design and analysis of randomised controlled trials endeavouring to reduce childhood mortality in India (CHAMPION) and Guinea-Bissau (EPICS), and randomised controlled trials in India (STRIPES) and The Gambia (SCORE) that demonstrated the effectiveness of additional schooling on educational attainment (STRIPES) in primary school age children. Follow-up trials in India (CHAMPION2/STRIPES2) continue this work. 

In the past I have worked on major randomised controlled trials and epidemiological studies in many disease areas, including asthma and breast cancer. I have also carried out methodological work on estimating and adjusting for the effect of measurement error in cohort studies where exposure over a lifetime is related to disease risk.

Research Area
Clinical trials
Maternal health
Statistical methods
Neonatal health
Randomised controlled trials
Disease and Health Conditions
Neurological disease
United Kingdom
The Gambia
Euro area
South Asia

Selected Publications

Depression and anxiety during the year before death from cancer.
Magill N; Walker J; Symeonides S; Gourley C; Hobbs H; Rosenstein D; Frost C; Sharpe M
Journal of Psychosomatic Research
Assessing Neurofilaments as Biomarkers of Neuroprotection in Progressive Multiple Sclerosis: From the MS-STAT Randomized Controlled Trial.
Williams TE; Holdsworth KP; Nicholas JM; Eshaghi A; Katsanouli T; Wellington H; Heslegrave A; Zetterberg H; Frost C; Chataway J
Neurology(R) neuroimmunology & neuroinflammation
Laughter as a paradigm of socio-emotional signal processing in dementia.
Sivasathiaseelan H; Marshall CR; Benhamou E; van Leeuwen JEP; Bond RL; Russell LL; Greaves C; Moore KM; Hardy CJD; Frost C
Cortex; a journal devoted to the study of the nervous system and behavior
'Do not attempt cardiopulmonary resuscitation' (DNACPR)-difficulty in discussions with older medical inpatients and their families: a survey of hospital doctors.
Walker J; Burke K; Magill N; van Niekerk M; Wanat M; Hobbs H; Rocroi I; Frost C; Sharpe M
BMJ Supportive & Palliative Care
Suicidal Thoughts in Patients With Cancer and Comorbid Major Depression: Findings From a Depression Screening Program.
Walker J; Magill N; Rosenstein DL; Frost C; Sharpe M
Journal of the Academy of Consultation-Liaison Psychiatry
Major Depression and Survival in People With Cancer.
Walker J; Mulick A; Magill N; Symeonides S; Gourley C; Burke K; Belot A; Quartagno M; van Niekerk M; Toynbee M
Psychosomatic medicine
The prevalence of anxiety in general hospital inpatients: A systematic review and meta-analysis.
Walker J; van Niekerk M; Hobbs H; Toynbee M; Magill N; Bold R; Hampsey E; Harriss E; Frost C; Sharpe M
General Hospital Psychiatry
See more Publications