Professor Chris Frost

BA MA DipStat (Cantab)

of Medical Statistics


Keppel Street
United Kingdom

+44 (0) 207 9272242

I joined LSHTM in 1992, having previously worked at the Department of Environmental & Preventive Medicine, St. Bartholomew’s Medical College on a range of clinical trials and epidemiological projects.

Prior to working at St. Bartholomew's I studied at Pembroke College Cambridge for a degree in Mathematics and the Diploma in Mathematical Statistics.


Department of Medical Statistics
Faculty of Epidemiology and Population Health


Statistical Methodology


I currently teach 12 sessions on the Generalised Linear Models module (2462), which forms part of the MSc. in Medical Statistics.

I am a member of the MSc. in Medical Statistics Exam Board at LSHTM.

Throughout my time at LSHTM I have had a major involvement with the MSc. in Medical Statistics, being course organiser (twice) and admissions tutor as well as the roles listed above.


My research combines methodological research interests with the conduct of collaborative research studies. Over the past decade a large component of this research has been in neurology, with a particular focus on Dementia, Huntington’s Disease (HD) and Multiple Sclerosis (MS). This work includes involvement with the design, conduct and statistical analysis of randomised controlled clinical trials, including a recently published phase II trial in secondary progressive MS (MS-STAT) that provided statistically significant evidence that statins slow both the rate of whole-brain atrophy and the clinical progression of the disease. A large phase III trial of statins in secondary progressive MS (MS-STAT2), funded by the NIHR, is starting this year.

From a methodological standpoint I have a particular interest in clinical trial design, addressing questions such as quantifying the advantages of extending follow-up, introducing interim visits and introducing novel design features such as run-in periods into trials in neurology.

I also collaborate with colleagues at the Department of Psychiatry at Oxford University, on a program of research involving the conduct and analysis of randomised trials and cohort studies of patients with depression linked to illnesses such as cancer.

My research is not limited to the UK. I have been involved in the design and analysis of randomised controlled trials endeavouring to reduce childhood mortality in India (CHAMPION) and Guinea-Bissau (EPICS), and a randomised controlled trial in India that demonstrated the effectiveness of additional schooling on educational attainment (STRIPES). Follow-up trials in India (CHAMPION/STRIPES-2) and Gambia (SCORE) continue this work. 

In the past I have worked on major randomised controlled trials and epidemiological studies in many disease areas, including asthma and breast cancer. I have also carried out methodological work on estimating and adjusting for the effect of measurement error in cohort studies where exposure over a lifetime is related to disease risk.

Research Area
Statistical methods
Neonatal health
Randomised controlled trials
Disease and Health Conditions
Neurological disease
United Kingdom
Gambia, The
European Union
South Asia

Selected Publications

Findings of Impaired Hearing in Patients With Nonfluent/Agrammatic Variant Primary Progressive Aphasia.
Hardy CJD; Frost C; Sivasathiaseelan H; Johnson JCS; Agustus JL; Bond RL; Benhamou E; Russell LL; Marshall CR; Rohrer JD
JAMA Neurology
Detection and localisation of hesitant steps in people with Alzheimer's disease navigating routes of varying complexity.
McCarthy I; Suzuki T; Holloway C; Poole T; Frost C; Carton A; Tyler N; Crutch S; Yong K
Health Technology Letters
Longitudinal measurement of serum neurofilament light in presymptomatic familial Alzheimer's disease.
Weston PSJ; Poole T; O'Connor A; Heslegrave A; Ryan NS; Liang Y; Druyeh R; Mead S; Blennow K; Schott JM
Alzheimer's research & therapy
Disease Course Varies According to Age and Symptom Length in Alzheimer's Disease.
Barnes J; Bartlett JW; Wolk DA; van der Flier WM; Frost C
Journal of Alzheimer's disease
Is improvement in comorbid major depression associated with longer survival in people with cancer? A long-term follow-up of participants in the SMaRT Oncology-2 and 3 trials.
Mulick A; Walker J; Puntis S; Symeonides S; Gourley C; Burke K; Wanat M; Frost C; Sharpe M
Journal of Psychosomatic Research
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