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Professor Chris Frost

BA MA DipStat (Cantab)

Professor
of Medical Statistics

Room
G32b

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
+44 (0) 207 9272242

I joined LSHTM in 1992, having previously worked at the Department of Environmental & Preventive Medicine, St. Bartholomew’s Medical College on a range of clinical trials and epidemiological projects.

Prior to working at St. Bartholomew's I studied at Pembroke College Cambridge for a degree in Mathematics and the Diploma in Mathematical Statistics.

Affiliations

Department of Medical Statistics
Faculty of Epidemiology and Population Health

Teaching

I currently teach 12 sessions on the Generalised Linear Models module (2462), which forms part of the MSc. in Medical Statistics.

I am Chair of the MSc. in Clinical Trials (Distance Learning) Exam Board at LSHTM.

I am a member of the MSc. in Medical Statistics Exam Board at LSHTM.

I am an external examiner for the MSc. in Global Health Science at Oxford University.

Throughout my time at LSHTM I have had a major involvement with the MSc. in Medical Statistics, being course organiser (twice) and admissions tutor as well as the roles listed above.

Research

My research combines methodological research interests with the conduct of collaborative research studies. Over the past decade a large component of this research has been in neurology, with a particular focus on Dementia, Huntington’s Disease (HD) and Multiple Sclerosis (MS). This work includes involvement with the design, conduct and statistical analysis of randomised controlled clinical trials, including a recently published phase II trial in secondary progressive MS (MS-STAT) that provided statistically significant evidence that statins slow both the rate of whole-brain atrophy and the clinical progression of the disease. A large phase III trial of statins in secondary progressive MS (MS-STAT2), funded by the NIHR, is starting this year.

From a methodological standpoint I have a particular interest in clinical trial design, addressing questions such as quantifying the advantages of extending follow-up, introducing interim visits and introducing novel design features such as run-in periods into trials in neurology.

I also collaborate with colleagues at the Department of Psychiatry at Oxford University, on a program of research involving the conduct and analysis of randomised trials and cohort studies of patients with depression linked to illnesses such as cancer.

My research is not limited to the UK. I have been involved in the design and analysis of randomised controlled trials endeavouring to reduce childhood mortality in India (CHAMPION) and Guinea-Bissau (EPICS), and a randomised controlled trial in India that demonstrated the effectiveness of additional schooling on educational attainment (STRIPES). Follow-up trials in India (CHAMPION/STRIPES-2) and Gambia (SCORE) continue this work. 

In the past I have worked on major randomised controlled trials and epidemiological studies in many disease areas, including asthma and breast cancer. I have also carried out methodological work on estimating and adjusting for the effect of measurement error in cohort studies where exposure over a lifetime is related to disease risk.

Research Area
Statistical methods
Neonatal health
Randomised controlled trials
Discipline
Statistics
Disease and Health Conditions
Neurological disease
Country
United Kingdom
Gambia, The
Guinea-Bissau
India
Region
European Union
South Asia

Selected Publications

Does depression treatment improve the survival of depressed patients with cancer? A long-term follow-up of participants in the SMaRT Oncology-2 and 3 trials.
Mulick, A. ; Walker, J. ; Puntis, S. ; Burke, K. ; Symeonides, S. ; Gourley, C. ; Wanat, M. ; Frost, C. ; Sharpe, M. ;
2018
Lancet Psychiatry
A double-blind placebo-controlled cross-over clinical trial of DONepezil In Posterior cortical atrophy due to underlying Alzheimer's Disease: DONIPAD study.
Ridha, B.H. ; Crutch, S. ; Cutler, D. ; Frost, C. ; Knight, W. ; Barker, S. ; Epie, N. ; Warrington, E.K. ; Kukkastenvehmas, R. ; Douglas, J. ; Rossor, M.N. ;
2018
Alzheimers Res Ther
Community health promotion and medical provision for neonatal health-CHAMPION cluster randomised trial in Nagarkurnool district, Telangana (formerly Andhra Pradesh), India.
Boone, P. ; Eble, A. ; Elbourne, D. ; Frost, C. ; Jayanty, C. ; Lakshminarayana, R. ; Mann, V. ; Mukherjee, R. ; Piaggio, G. ; Reddy, P. ;
2017
PLoS Med
Design optimization for clinical trials in early-stage manifest Huntington's disease.
Frost, C. ; Mulick, A. ; Scahill, R.I. ; Owen, G. ; Aylward, E. ; Leavitt, B.R. ; Durr, A. ; Roos, R.A.C. ; Borowsky, B. ; Stout, J.C. ; Reilmann, R. ; Langbehn, D.R. ; Tabrizi, S.J. ; Sampaio, C. ; TRACK-HD Investigators, . ;
2017
Mov Disord
Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple sclerosis (MS-STAT): a randomised, placebo-controlled, phase 2 trial.
Chataway, J. ; Schuerer, N. ; Alsanousi, A. ; Chan, D. ; MacManus, D. ; Hunter, K. ; Anderson, V. ; Bangham, C.R. ; Clegg, S. ; Nielsen, C. ; Fox, N.C. ; Wilkie, D. ; Nicholas, J.M. ; Calder, V.L. ; Greenwood, J. ; Frost, C. ; Nicholas, R. ;
2014
Lancet
Potential endpoints for clinical trials in premanifest and early Huntington's disease in the TRACK-HD study: analysis of 24 month observational data
Tabrizi, S.J.; Reilmann, R.; Roos, R.A.C.; Durr, A.; Leavitt, B.; Owen, G.; Jones, R.; Johnson, H.; Craufurd, D.; Hicks, S.L.; Kennard, C.; Landwehrmeyer, B.; Stout, J.C.; Borowsky, B.; Scahill, R.I.; Frost, C.; Langbehn, D.R.; Investigators, T.-H.
2012
Lancet Neurology
See all Professor Chris Frost's Publications