Dr Amanda Francisco
BSc MSc PhD
+44 (0)20 7612 7864
Learning tutor: Parasitology Module IDM203, Infectious Diseases MSc.
Supervised/co-supervised MSc and PhD student projects.
- Exploit in vivo imaging technology to study Chagas' disease pathogenesis and assess drug effectiveness;
- Test new compounds/candidates mainly for DNDi and GSK to treat Chagas’ disease using the bioluminescent model;
- The major pathology of Chagas disease is heart damage including cardiomyopathy, cardiac inflammation and fibrosis. The use of a new non-invasive tecnology as the electrocardiogram (ECG) will complement our current experiments by providing clinical data on heart function, which can be mapped onto the bioluminescent data we have on the infection kinetics. It can also be used to look at changes in heart parameters of infected mice undergoing treatment with novel compounds/drug candidates.
Drug discovery and development
Disease and Health Conditions
Neglected Tropical Diseases (NTDs)