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Dr Amanda Francisco

BSc MSc PhD

Research Fellow
in Parasitology

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
+44 (0)20 7612 7864

Affiliations

Department of Pathogen Molecular Biology
Faculty of Infectious and Tropical Diseases

Research

  • Exploit in vivo imaging technology to study Chagas' disease pathogenesis and assess drug effectiveness;

 

  • Test new compounds/candidates mainly for DNDi and GSK to treat Chagas’ disease using the bioluminescent model;

 

  • The major pathology of Chagas disease is heart damage including cardiomyopathy, cardiac inflammation and fibrosis. The use of a new non-invasive tecnology as the electrocardiogram (ECG) will complement our current experiments by providing clinical data on heart function, which can be mapped onto the bioluminescent data we have on the infection kinetics. It can also be used to look at changes in heart parameters of infected mice undergoing treatment with novel compounds/drug candidates.


 

 

 

 

 

 

Research Area
Drug discovery and development
Parasites
Trypanosomes
Chemotherapy
Protozoa
Discipline
Pathology
Disease and Health Conditions
Chagas Disease
Neglected Tropical Diseases (NTDs)
Region
World