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Tony Fletcher

PhD

Associate Professor

Room
Room 229

LSHTM
15-17 Tavistock Place
London
WC1H 9SH
United Kingdom

Tel.
+44 (0)20 7927 2429

My employment is divided between part-time appointments for Public Health England and London School of Hygiene and Tropical Medicine.  I have been at LSHTM since 1992, and PHE since 2013. At PHE, I am PI for study of arsenic in drinking water in Cornwall UK, and work in the UK National Institute of Health Research funded Health Protection Research Unit “Health Impact of Environmental Hazards” with teams at King’s College London, Imperial College and Public Health England. At LSHTM, I contribute to several studies of perfluorinated alkyl substance, PFAS-exposed communities in Ronneby, Sweden and in Veneto, Italy.

I was Adjunct Research Professor in Environmental Health in the School of Public Health, Boston University, Massachusetts, USA, 2007-2017 and elected President of the International Society for Environmental Epidemiology: Presidential term 2004-5.

Previously employed at IARC, Lyon; MRC Environmental Epidemiology Unit, Southampton, Birmingham University; Aston Universities. 

Affiliations

Public Health, Environments and Society

Teaching

I contribute to teaching on the Public Health Msc, in particular for the Environmental Health stream and the teaching unit on Environmental Health Policy.

Research

My principal research interests are environmental epidemiology (predominately on disease risks in relation to drinking water contaminants; cancer in relation to occupation, arsenic and drinking water; and respiratory disease in relation to air pollution) and environmental health risk assessment (embracing quantitative risk assessment, risk perception, environmental health policy making in general and standard setting for chemicals in particular). A major recent effort has been on perfluorinated chemicals.

I am Principle Investigator in a study of arsenic in drinking water in private water supplies in Cornwall UK: water contamination, soil contamination and urine, nail and hair biomarkers.

I am co-investigator in EU funded Cost action “Industrially Contaminated Sites and Health Network (ICSHNet)”. 

I am co-investigator in UK National Institute of Health Research funded Health Protection Research Unit “Health Impact of Environmental Hazards” co-managed by King’s College London, Imperial College and Public Health England. I am co-managing the sub-project “Epidemiological assessment of low level environmental exposures”.  

I am co-investigator on studies of health effects of perfluoroalkyl substance (PFAS) fire fighting foam exposures in Sweden. This programme led by Gothenberg and Lund Universities, is in a community exposed via drinking water exposure contaminated by fire fighting foams from a nearby military airfield. I am PI on project funded by FORMAS: “The role of renal and intestinal pathways for elimination and half-life of perfluorinated alkyl acids”. I am co-investigator in three projects funded by FORTE, on analyses of serum PFAS and serum hormones and lipids, on exposure modelling and on birth outcome/infant health in relation to in-utero exposure to PFAS 

I am co-investigator on two studies of health effects of perfluoroalkyl substance (PFAS) in drinking water in Veneto Italy. “Use and implementation of full-chain exposure software to develop pharmacokinetics modeling of PFAS and highlight toxicological behavior and risk for human health”, (University of Bologna), and “Cross-sectional epidemiological study on the association between internal dose of PFAS and anthropometric and bio-humoral parameters in the exposed Veneto population”, (University of Padova).

Past research

C8 Science Panel Community study.

I co-directed an epidemiological research programme on the potential health effects of Perfluoro-octanoic acid (PFOA or C8) and other perfluorinated chemicals in a community adjacent to a Teflon manufacturing facility in West Virginia, USA. These studies include a cross sectional study of Cancer, Immune function, Liver and Hormone disorders in the community and a Geographical Study of Cancer Incidence in the counties around the plant. More details at http://www.c8sciencepanel.org/study.html

Other past funded research:

PURE - Pollutants in the Urban Environment. Funded by UK EPSRC - Engineering and Physical Science Research Council.

In Collaboration with Universities of Manchester, Sheffield and Cardiff, we have developed developed a systematic method for integrating health and environmental impacts of urban pollutants. I am coordinating the LSHTM team input. 2005-2009.

SAFIR - Safe and High Quality Food Production using Low Quality Waters and Improved Irrigation Systems and Management.

European Union FP6 funding. Working with agricultural scientists, I was coordinating the LSHTM team input on epidemiology and risk assessment of new irrigation technologies. 2005-2009. 2006-2009

INTARESE - Integrated Assessment Of Health Risks From Environmental Stressors In Europe

European Union FP6 funding. I have been contributing in particular to input on Europe wide risk assessment of water related environmental health risks. 2006-2010

Arsenic Health Risk Assessment and Molecular Epidemiology "ASHRAM"

Coordinating international project of 7 teams, funded under the EU Quality of Life programme. It is a case control study of three cancers (bladder, skin, and kidney) in relation to the cumulative ingestion of arsenic via drinking water, in some areas of Hungary, Romania, and Slovakia. Research partners in those countries plus Austria and Sweden. Project has components which will assess the effect of inter-individual variation in arsenic metabolism and DNA repair on the carcinogenic risk of arsenic. Jan 2002-December 2004.

Pollution and the Young "PATY"

Coordinating international project of 14 teams, funded under the EU Quality of Life programme. It entails a reanalysis of a global set of datasets of studies of childhood respiratory health and air pollution, with Participation from Austria, Bulgaria, Germany, Italy, Hungary, the Netherlands, Poland, Russia, Czech Republic, Slovakia, Switzerland, USA and UK. Total study population involves some 70,000 children from 140 areas. December 2002 - November 2004.

Occupation, environment and lung cancer in Central and Eastern Europe

Providing LSHTM input (exposure assessment component) into this case control study with 6 Eastern European partners and co-ordinated by WHO/IARC Lyon. Field work took place in Russia, Hungary, Poland, Romania, Poland and Belarus. Linked studies are ongoing in the same areas addressing risk factors for oral cavity, larynx and kidney cancers. Funded by EC INCO-COPERNICUS programme and US National Cancer Institute.

9 cities study of air pollution and childhood respiratory health

In the Russian Federation and World Bank/CPPI Russian Environmental Management Project (overall coordination by Harvard School of Public Health), 1997-2000.

Community based arsenic mitigation model: validation by epidemiological methods

Worked with Dhaka Community Hospital on protocol development and pilot phase. Funded by DFID Bangladesh, March 2000-March 2001.

CESAR - Central European Study of Air Pollution and Respiratory Health

In 25 communities in Bulgaria, Czech and Slovak Republics, Hungary, Poland and Romania. This is a cross-sectional study of respiratory symptoms, including asthma, and lung function in 7-11 years olds related to current and (estimated) chronic exposure to particulate and gaseous contaminants. Directed sub-project on risk perception and communication within same research programme. First phase funded by EC-PHARE Programme 1994-97; Second phase funded by EC INCO-COPERNICUS Programme 1998-2000.

Chemical Incident Health Impact Prediction Model

Principal Investigator for the project, 1997-1999. Development of a model for the prediction of health impact in the event of large scale chemical incident on Canvey Island Essex, UK. Funded by Department of Health 1997-1999.

SAGE - Small Area Geographical study of Environmental Factors in Health

Principal Investigator. A study of the relationship between environmental factors and ill-health right across the Greater London area, focusing in particular on estimated outdoor air pollution levels and road traffic density in relation to cardio-respiratory deaths and hospital emergency admissions. Funded by North and South ThamesRegional Health Authorities. 1996-98

Other:

ISEE: President of the ISEE - International Society for Environmental Epidemiology. Presidential term 2004 & 2005 ARTS: Advisor on contemporary arts commissions and exhibitions programme at the School. WATCH: Member of the Working Group on the Assessment of Toxic Chemicals ("WATCH"), providing advice on setting occupational exposure limits for chemicals, within the UK Health and Safety Commission. The Big Smoke: Lead organiser of 50th anniversary commemorative conference on the 1952 London Smog episode. December 9-10 2002.  Health at the Crossroads - Transport Policy and Urban Health, LSHTM Fifth Public Health Forum: Conference coordinator. April 1995.

Selected Publications

Zürich Statement on Future Actions on Per- and Polyfluoroalkyl Substances (PFASs).
Ritscher, A. ; Wang, Z. ; Scheringer, M. ; Boucher, J.M. ; Ahrens, L. ; Berger, U. ; Bintein, S. ; Bopp, S.K. ; Borg, D. ; Buser, A.M. ; Cousins, I. ; DeWitt, J. ; Fletcher, T. ; Green, C. ; Herzke, D. ; Higgins, C. ; Huang, J. ; Hung, H. ; Knepper, T. ; Lau, C.S. ; Leinala, E. ; Lindstrom, A.B. ; Liu, J. ; Miller, M. ; Ohno, K. ; Perkola, N. ; Shi, Y. ; Småstuen Haug, L. ; Trier, X. ; Valsecchi, S. ; van der Jagt, K. ; Vierke, L. ;
2018
Environ Health Perspect
Half-lives of PFOS, PFHxS and PFOA after end of exposure to contaminated drinking water.
Li, Y. ; Fletcher, T. ; Mucs, D. ; Scott, K. ; Lindh, C.H. ; Tallving, P. ; Jakobsson, K. ;
2017
Occup Environ Med
Perfluoroalkyl Substances, Sex Hormones, and Insulin-like Growth Factor-1 at 6-9 Years of Age: A Cross-Sectional Analysis within the C8 Health Project.
Lopez-Espinosa, M.J.; Mondal, D.; Armstrong, B.G.; Eskenazi, B.; Fletcher, T.;
2016
Environ Health Perspect
Urinary arsenic profiles reveal exposures to inorganic arsenic from private drinking water supplies in Cornwall, UK.
Middleton, D.R. ; Watts, M.J. ; Hamilton, E.M. ; Ander, E.L. ; Close, R.M. ; Exley, K.S. ; Crabbe, H. ; Leonardi, G.S. ; Fletcher, T. ; Polya, D.A. ;
2016
Sci Rep
Obesity, diabetes, and associated costs of exposure to endocrine-disrupting chemicals in the European Union.
Legler, J. ; Fletcher, T. ; Govarts, E. ; Porta, M. ; Blumberg, B. ; Heindel, J.J. ; Trasande, L. ;
2015
J Clin Endocrinol Metab
Polymorphisms in DNA repair genes XRCC1 and XRCC3, occupational exposure to arsenic and sunlight, and the risk of non-melanoma skin cancer in a European case-control study.
Surdu, S. ; Fitzgerald, E.F. ; Bloom, M.S. ; Boscoe, F.P. ; Carpenter, D.O. ; Haase, R.F. ; Gurzau, E. ; Rudnai, P. ; Koppova, K. ; Vahter, M. ; Leonardi, G. ; Goessler, W. ; Kumar, R. ; Fletcher, T. ;
2014
Environ Res
Associations between PFOA, PFOS and changes in the expression of genes involved in cholesterol metabolism in humans.
Fletcher, T. ; Galloway, T.S. ; Melzer, D. ; Holcroft, P. ; Cipelli, R. ; Pilling, L.C. ; Mondal, D. ; Luster, M. ; Harries, L.W. ;
2013
Environ Int
Mortality in British military participants in human experimental research into chemical warfare agents at Porton Down: cohort study
Venables, K.M.; Brooks, C.; Linsell, L.; Keegan, T.J.; Langdon, T.; Fletcher, T.; Nieuwenhuijsen, M.J.; MacOnochie, N.E.S.; Doyle, P.; Beral, V.; Carpenter, L.M.
2009
BMJ
See all Tony Fletcher's Publications