Close

Dr Helen Fletcher

BSc PhD

Associate Professor
in Immunology and Director, TB Centre

Room
K484

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
+44 (0) 20 7927 2666

I received my PhD in Microbiology from the University of Leeds and began working in tuberculosis (TB) as a Postdoctoral Research Fellow at University College London in 1999. In 2002 I moved to the Jenner Institute, University of Oxford as an immunologist for the first-in-man trial of a new TB vaccine, MVA85A. I worked on the MVA85A vaccine through Phase I, Phase II and Phase IIb efficacy trials.  

After 10 years at the Jenner Institute I established my own research group at the London School of Hygiene & Tropical Medicine (LSHTM) where I continue my research in TB vaccines and immune correlates of risk. 

In 2015 I became Director/Deputy Director of the TB Centre at LSHTM http://tb.lshtm.ac.uk/. The TB Centre brings people together from across the different Departments and Faculties of LSHTM who share a common research interest in TB.  Recognizing the value of sharing ideas and the power of a collective voice, the TB Centre provides a forum through which members can more effectively enhance their own research and influence policy. 

In 2017, I applied for and obtained funding to establish The VALIDATE Network - Vaccine development for complex intracellular neglected pathogens https://www.validate-network.org/.  This is an MRC funded Network of UK and LMIC scientists working to develop vaccines for TB, melioidosis, leishmaniasis and leprosy.  By sharing cross-pathogen, cross-discipline experience we hope to accelerate the development of vaccines for all these pathogens.  I’m co-PI of The VALIDATE Network with Helen McShane at the university of Oxford.

I’m also part of the Bill and Melinda Gates Foundation sponsored “Collaboration for TB Vaccine Development (CTVD)” https://www.ctvd.co/Pages/Strategy.aspx.  In 2016 I become co-chair of the “Conventional T-cell Community” within the CTVD. This a community of global experts in cellular immunology who discuss and identify the major challenges and key experiments needed to develop more effective T cell inducing vaccines for protection against TB.

Affiliations

Faculty of Infectious and Tropical Diseases
Department of Immunology and Infection

Centres

Tuberculosis (TB) Centre
Vaccine Centre

Teaching

I am co-organizer of the Vaccine Immunology MSc module with and a tutor on the Distance Learning programme

Research

Research Area
Innate immunity
T-cell immunology
Vaccines
Disease control
Global Health
Immunisation
Discipline
Immunology
Bioinformatics
Vaccinology
Disease and Health Conditions
Infectious disease
Malaria
Tuberculosis
Country
Gambia, The
Senegal
Thailand
South Africa
Region
Sub-Saharan Africa (all income levels)

Selected Publications

T-cell activation is an immune correlate of risk in BCG vaccinated infants.
Fletcher, H.A. ; Snowden, M.A. ; Landry, B. ; Rida, W. ; Satti, I. ; Harris, S.A. ; Matsumiya, M. ; Tanner, R. ; O'Shea, M.K. ; Dheenadhayalan, V. ; Bogardus, L. ; Stockdale, L. ; Marsay, L. ; Chomka, A. ; Harrington-Kandt, R. ; Manjaly-Thomas, Z.R. ; Naranbhai, V. ; Stylianou, E. ; Darboe, F. ; Penn-Nicholson, A. ; Nemes, E. ; Hatheril, M. ; Hussey, G. ; Mahomed, H. ; Tameris, M. ; McClain, J.B. ; Evans, T.G. ; Hanekom, W.A. ; Scriba, T.J. ; McShane, H. ;
2016
Nat Commun
Human newborn bacille Calmette-Guérin vaccination and risk of tuberculosis disease: a case-control study.
Fletcher, H.A.; Filali-Mouhim, A.; Nemes, E.; Hawkridge, A.; Keyser, A.; Njikan, S.; Hatherill, M.; Scriba, T.J.; Abel, B.; Kagina, B.M.; Veldsman, A.; Agudelo, N.M.; Kaplan, G.; Hussey, G.D.; Sekaly, R.P.; Hanekom, W.A.; BCG study team, .; COLLABORATORS;Minnies, D. ; Tanner, R. ; Chung, C.K. ; Cameron, M.J. ; Goulet, J.P. ; Gaujoux, R. ; Hughes, J. ; Gelderbloem, S. ; Iloni, K. ; Buchanan, M. ; van der Merwe, L. ; Burger, A. ; Denation, L. ; Mlanjeni, S. ; Abrahams, S. ; Shepherd, R. ; Geldenhuys, M. ; Seoighe, C. ; Soares, A. ; Gamieldien, H. ; Sidibana, M. ; Mahomed, H. ; McShane, H. ; Hill, A.V. ;
2016
BMC Med
Human biomarkers: can they help us to develop a new tuberculosis vaccine?
Fletcher, H.A. ; Dockrell, H.M. ;
2016
Future Microbiol
Distinct Transcriptional and Anti-Mycobacterial Profiles of Peripheral Blood Monocytes Dependent on the Ratio of Monocytes: Lymphocytes.
Naranbhai, V. ; Fletcher, H.A. ; Tanner, R. ; O'Shea, M.K. ; McShane, H. ; Fairfax, B.P. ; Knight, J.C. ; Hill, A.V. ;
2015
EBioMedicine
Gene expression and cytokine profile correlate with mycobacterial growth in a human BCG challenge model.
Matsumiya, M. ; Satti, I. ; Chomka, A. ; Harris, S.A. ; Stockdale, L. ; Meyer, J. ; Fletcher, H.A. ; McShane, H. ;
2014
J Infect Dis
Blood monocyte-lymphocyte ratios identify adults at risk of incident tuberculosis amongst patients initiating antiretroviral therapy.
Naranbhai, V.; Hill, A.V.; Abdool Karim, S.S.; Naidoo, K.; Abdool Karim, Q.; Warimwe, G.M.; McShane, H.; Fletcher, H.;
2013
J Infect Dis
Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans.
McShane, H. ; Pathan, A.A. ; Sander, C.R. ; Keating, S.M. ; Gilbert, S.C. ; Huygen, K. ; Fletcher, H.A. ; Hill, A.V. ;
2004
Nat Med
See all Dr Helen Fletcher's Publications