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Professor Helen Fletcher

BSc PhD

Professor
of Immunology

Room
K396

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
+44 (0) 20 7927 2361

As Professor of Immunology at LSHTM I focus on Tuberculosis (TB) vaccines and immune correlates of risk. Since 2000 I have worked with scientists across Africa - in The Gambia, Zambia, Ethiopia, Senegal, Kenya, South Africa and Uganda.

I am also co- Principal Investigator of The VALIDATE Network. An MRC/BBSRC GCRF funded Network of UK and LMIC scientists working to develop vaccines for TB, melioidosis, leishmaniasis and leprosy.

My Ph.D was in Microbiology from the University of Leeds, where I also completed my undergraduate degree. I'm co-Editor of the journal Tropical Medicine and International Health and have written over 100 peer review research articles and chapters.

In April 2018 I joined UKRI on secondment as Director of International Development. As Director of International Development I'm responsible for strategy and the delivery of the Global Challenges Research Fund (GCRF) and Newton Funds.

Affiliations

Department of Infection Biology
Faculty of Infectious and Tropical Diseases

Centres

TB Centre
Vaccine Centre

Teaching

Co-organizer of the Vaccine Immunology MSc module and a tutor on the IDM502 Tuberculosis Distance Learning programme

Research

See here for a discussion of the global challenge of tuberculosis

And here is a video which describes some of the work we did on TB vaccine development

In this radio show we talk about how vaccines work

Research Area
Innate immunity
T-cell immunology
Vaccines
Disease control
Global Health
Immunisation
Discipline
Immunology
Bioinformatics
Vaccinology
Disease and Health Conditions
Infectious disease
Malaria
Tuberculosis
Country
The Gambia
Senegal
Thailand
South Africa
Region
Sub-Saharan Africa (all income levels)

Selected Publications

How can we improve priority-setting for investments in health research? A case study of tuberculosis.
Khan MS; Rahman-Shepherd A; Painter H; Fletcher H
2019
Health Research Policy and Systems
Cytomegalovirus infection is a risk factor for tuberculosis disease in infants.
Müller J; Tanner R; Matsumiya M; Snowden MA; Landry B; Satti I; Harris SA; O'Shea MK; Stockdale L; Marsay L
2019
JCI insight
RUTI Vaccination Enhances Inhibition of Mycobacterial Growth ex vivo and Induces a Shift of Monocyte Phenotype in Mice.
Prabowo SA; Painter H; Zelmer A; Smith SG; Seifert K; Amat M; Cardona P-J; Fletcher HA
2019
Frontiers in Immunology
Cytomegalovirus Antibody Responses Associated With Increased Risk of Tuberculosis Disease in Ugandan Adults.
Stockdale L; Nash S; Farmer R; Raynes J; Mallikaarjun S; Newton R; Fletcher HA
2019
The Journal of infectious diseases
The convergent epidemiology of tuberculosis and human cytomegalovirus infection.
Cobelens F; Nagelkerke N; Fletcher H
2018
F1000Research
HIV, HCMV and mycobacterial antibody levels: a cross-sectional study in a rural Ugandan cohort.
Stockdale L; Nash S; Nalwoga A; Gibson L; Painter H; Raynes J; Asiki G; Newton R; Fletcher H
2018
Tropical Medicine & International Health
Human newborn bacille Calmette-Guérin vaccination and risk of tuberculosis disease: a case-control study.
Fletcher HA; Filali-Mouhim A; Nemes E; Hawkridge A; Keyser A; Njikan S; Hatherill M; Scriba TJ; Abel B; Kagina BM
2016
BMC medicine
T-cell activation is an immune correlate of risk in BCG vaccinated infants.
Fletcher HA; Snowden MA; Landry B; Rida W; Satti I; Harris SA; Matsumiya M; Tanner R; O'Shea MK; Dheenadhayalan V
2016
Nature communications
Distinct Transcriptional and Anti-Mycobacterial Profiles of Peripheral Blood Monocytes Dependent on the Ratio of Monocytes: Lymphocytes.
Naranbhai V; Fletcher HA; Tanner R; O'Shea MK; McShane H; Fairfax BP; Knight JC; Hill AVS
2015
EBioMedicine
The association between the ratio of monocytes: lymphocytes and risk of tuberculosis among HIV-infected postpartum women.
Naranbhai V; Moodley D; Chipato T; Stranix-Chibanda L; Nakabaiito C; Kamateeka M; Musoke P; Manji K; George K; Emel LM
2014
Journal of acquired immune deficiency syndromes (1999)
Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans.
McShane H; Pathan AA; Sander CR; Keating SM; Gilbert SC; Huygen K; Fletcher HA; Hill AVS
2004
Nature medicine
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