Dr Helen Fletcher
in Immunology and Director, TB Centre
I received my PhD in Microbiology from the University of Leeds and began working in tuberculosis (TB) as a Postdoctoral Research Fellow at University College London in 1999. In 2002 I moved to the Jenner Institute, University of Oxford as an immunologist for the first-in-man trial of a new TB vaccine, MVA85A. I worked on the MVA85A vaccine through Phase I, Phase II and Phase IIb efficacy trials.
After 10 years at the Jenner Institute I established my own research group at the London School of Hygiene & Tropical Medicine (LSHTM) where I continue my research in TB vaccines and immune correlates of risk.
In 2015 I became Director/Deputy Director of the TB Centre at LSHTM http://tb.lshtm.ac.uk/. The TB Centre brings people together from across the different Departments and Faculties of LSHTM who share a common research interest in TB. Recognizing the value of sharing ideas and the power of a collective voice, the TB Centre provides a forum through which members can more effectively enhance their own research and influence policy.
In 2017, I applied for and obtained funding to establish The VALIDATE Network - Vaccine development for complex intracellular neglected pathogens https://www.validate-network.org/. This is an MRC funded Network of UK and LMIC scientists working to develop vaccines for TB, melioidosis, leishmaniasis and leprosy. By sharing cross-pathogen, cross-discipline experience we hope to accelerate the development of vaccines for all these pathogens. I’m co-PI of The VALIDATE Network with Helen McShane at the university of Oxford.
I’m also part of the Bill and Melinda Gates Foundation sponsored “Collaboration for TB Vaccine Development (CTVD)” https://www.ctvd.co/Pages/Strategy.aspx. In 2016 I become co-chair of the “Conventional T-cell Community” within the CTVD. This a community of global experts in cellular immunology who discuss and identify the major challenges and key experiments needed to develop more effective T cell inducing vaccines for protection against TB.
I am co-organizer of the Vaccine Immunology MSc module with and a tutor on the Distance Learning programme
My interests are in vaccine development for TB and identification of immune mechanisms important for protection from TB