Professor Helen Fletcher

BSc PhD

Professor

Professor of Immunology, Global Challenges Research Fund Challenge Leader in Global Health and Director of International Development, UKRI

Room

K396

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.

+44 (0) 20 7927 2361

Helen Fletcher is a Professor of Immunology at the London School of Hygiene & Tropical Medicine (LSHTM) and Director of International Development, UKRI.

As Director of International Development Helen is responsible for the development of strategy and the delivery of the Global Challenges Research Fund (GCRF) and Newton programmes.

Helen is a research group leader at LSHTM where she continues her research in Tuberculosis (TB) vaccines and immune correlates of risk. Since 2000 She has worked with scientists across Africa in The Gambia, Zambia, Ethiopia, Senegal, Kenya, South Africa and Uganda. Helen is co- Principal Investigator of The VALIDATE Network. An MRC/BBSRC GCRF funded Network of UK and LMIC scientists working to develop vaccines for TB, melioidosis, leishmaniasis and leprosy. Helen was Director of the TB Centre at LSHTM and in April 2018 joined UKRI on secondment as Challenge Leader in Global Health.

Helen has a Ph.D in Microbiology from the University of Leeds where she also completed her undergraduate degree. She is co-Editor of the journal Tropical Medicine and International Health and has written over 100 peer review research articles and chapters.

Affiliations

Department of Immunology and Infection

Faculty of Infectious and Tropical Diseases

Centres

Tuberculosis (TB) Centre

Vaccine Centre

Teaching

I am co-organizer of the Vaccine Immunology MSc module with and a tutor on the Distance Learning programme

Research

My interests are in vaccine development for TB and identification of immune mechanisms important for protection from TB

https://www.youtube.com/watch?v=75Die7MQBec&feature=youtu.be

http://features.lshtm.ac.uk/project/ending-tb-the-race-to-control-a-disease-in-hiding

http://www.aeras.org/exposed

http://www.bfm.my/pfizer-helen-fletcher-andrew-pollard-vaccine-design.html#basic-modal-content

Research Area

Innate immunity

T-cell immunology

Vaccines

Disease control

Global Health

Immunisation

Discipline

Immunology

Bioinformatics

Vaccinology

Disease and Health Conditions

Infectious disease

Malaria

Tuberculosis

Country

Gambia, The

Senegal

Thailand

South Africa

Region

Sub-Saharan Africa (all income levels)

Selected Publications

T-cell activation is an immune correlate of risk in BCG vaccinated infants.

Fletcher, H.A. ; Snowden, M.A. ; Landry, B. ; Rida, W. ; Satti, I. ; Harris, S.A. ; Matsumiya, M. ; Tanner, R. ; O'Shea, M.K. ; Dheenadhayalan, V. ; Bogardus, L. ; Stockdale, L. ; Marsay, L. ; Chomka, A. ; Harrington-Kandt, R. ; Manjaly-Thomas, Z.R. ; Naranbhai, V. ; Stylianou, E. ; Darboe, F. ; Penn-Nicholson, A. ; Nemes, E. ; Hatheril, M. ; Hussey, G. ; Mahomed, H. ; Tameris, M. ; McClain, J.B. ; Evans, T.G. ; Hanekom, W.A. ; Scriba, T.J. ; McShane, H. ;

2016

Nat Commun

Human newborn bacille Calmette-Guérin vaccination and risk of tuberculosis disease: a case-control study.

Fletcher, H.A.; Filali-Mouhim, A.; Nemes, E.; Hawkridge, A.; Keyser, A.; Njikan, S.; Hatherill, M.; Scriba, T.J.; Abel, B.; Kagina, B.M.; Veldsman, A.; Agudelo, N.M.; Kaplan, G.; Hussey, G.D.; Sekaly, R.P.; Hanekom, W.A.; BCG study team, .; COLLABORATORS;Minnies, D. ; Tanner, R. ; Chung, C.K. ; Cameron, M.J. ; Goulet, J.P. ; Gaujoux, R. ; Hughes, J. ; Gelderbloem, S. ; Iloni, K. ; Buchanan, M. ; van der Merwe, L. ; Burger, A. ; Denation, L. ; Mlanjeni, S. ; Abrahams, S. ; Shepherd, R. ; Geldenhuys, M. ; Seoighe, C. ; Soares, A. ; Gamieldien, H. ; Sidibana, M. ; Mahomed, H. ; McShane, H. ; Hill, A.V. ;

2016

BMC Med

Human biomarkers: can they help us to develop a new tuberculosis vaccine?

Fletcher, H.A. ; Dockrell, H.M. ;

2016

Future Microbiol

Transcriptional changes induced by candidate malaria vaccines and correlation with protection against malaria in a human challenge model.

Dunachie, S. ; Berthoud, T. ; Hill, A.V. ; Fletcher, H.A. ;

2015

Vaccine

Distinct Transcriptional and Anti-Mycobacterial Profiles of Peripheral Blood Monocytes Dependent on the Ratio of Monocytes: Lymphocytes.

Naranbhai, V. ; Fletcher, H.A. ; Tanner, R. ; O'Shea, M.K. ; McShane, H. ; Fairfax, B.P. ; Knight, J.C. ; Hill, A.V. ;