Dr Helen Fletcher

BSc PhD

Associate Professor

in Immunology and Director, TB Centre

Room

K484

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.

+44 (0) 20 7927 2666

I gained a PhD in Medical Microbiology from the University of Leeds and became interested in tuberculosis (TB) in 1999 during my first postdoctoral position at University College London. In 2002 I moved to the Jenner Institute at the University of Oxford as an immunologist for the first-in-man trial of a new TB vaccine, MVA85A. After 10 years at the Jenner Institute I moved to the London School of Hygiene & Tropical Medicine to establish my group, based in the Immunology and Infection Department, which focuses on immune correlates and the host response to TB vaccination. In 2015 I became Director of the TB Centre: http://tb.lshtm.ac.uk/ at the London School of Hygiene & Tropical Medicine and in 2016 I became co-chair of the T-cell Immunology working group for the Collaboration for TB Vaccine Discovery (CTVD) at the Bill & Melinda Gates Foundation.

Affiliations

Faculty of Infectious and Tropical Diseases

Immunology and Infection Department

Centres

Tuberculosis (TB) Centre

Vaccine Centre

Teaching

I am co-organizer of the Vaccine Immunology MSc module with Eleanor Riley and I am a tutor on the Distance Learning programme

Research

My interests are in vaccine development for TB and identification of immune mechanisms important for protection from TB

https://www.youtube.com/watch?v=75Die7MQBec&feature=youtu.be

http://features.lshtm.ac.uk/project/ending-tb-the-race-to-control-a-disease-in-hiding

http://www.aeras.org/exposed

http://www.bfm.my/pfizer-helen-fletcher-andrew-pollard-vaccine-design.html#basic-modal-content

Research Area

Innate immunity

T-cell immunology

Vaccines

Disease control

Global Health

Immunisation

Discipline

Immunology

Bioinformatics

Vaccinology

Disease and Health Conditions

Infectious disease

Malaria

Tuberculosis

Country

Gambia, The

Senegal

Thailand

South Africa

Region

Sub-Saharan Africa (all income levels)

Selected Publications

T-cell activation is an immune correlate of risk in BCG vaccinated infants.

Fletcher, H.A. ; Snowden, M.A. ; Landry, B. ; Rida, W. ; Satti, I. ; Harris, S.A. ; Matsumiya, M. ; Tanner, R. ; O'Shea, M.K. ; Dheenadhayalan, V. ; Bogardus, L. ; Stockdale, L. ; Marsay, L. ; Chomka, A. ; Harrington-Kandt, R. ; Manjaly-Thomas, Z.R. ; Naranbhai, V. ; Stylianou, E. ; Darboe, F. ; Penn-Nicholson, A. ; Nemes, E. ; Hatheril, M. ; Hussey, G. ; Mahomed, H. ; Tameris, M. ; McClain, J.B. ; Evans, T.G. ; Hanekom, W.A. ; Scriba, T.J. ; McShane, H. ;

Nat Commun

Human newborn bacille Calmette-Guérin vaccination and risk of tuberculosis disease: a case-control study.

Fletcher, H.A.; Filali-Mouhim, A.; Nemes, E.; Hawkridge, A.; Keyser, A.; Njikan, S.; Hatherill, M.; Scriba, T.J.; Abel, B.; Kagina, B.M.; Veldsman, A.; Agudelo, N.M.; Kaplan, G.; Hussey, G.D.; Sekaly, R.P.; Hanekom, W.A.; BCG study team, .; COLLABORATORS;Minnies, D. ; Tanner, R. ; Chung, C.K. ; Cameron, M.J. ; Goulet, J.P. ; Gaujoux, R. ; Hughes, J. ; Gelderbloem, S. ; Iloni, K. ; Buchanan, M. ; van der Merwe, L. ; Burger, A. ; Denation, L. ; Mlanjeni, S. ; Abrahams, S. ; Shepherd, R. ; Geldenhuys, M. ; Seoighe, C. ; Soares, A. ; Gamieldien, H. ; Sidibana, M. ; Mahomed, H. ; McShane, H. ; Hill, A.V. ;

BMC Med

Human biomarkers: can they help us to develop a new tuberculosis vaccine?

Fletcher, H.A.; Dockrell, H.M.;

Future Microbiol

Transcriptional changes induced by candidate malaria vaccines and correlation with protection against malaria in a human challenge model.

Dunachie, S. ; Berthoud, T. ; Hill, A.V. ; Fletcher, H.A. ;

Vaccine

Distinct Transcriptional and Anti-Mycobacterial Profiles of Peripheral Blood Monocytes Dependent on the Ratio of Monocytes: Lymphocytes.

Naranbhai, V. ; Fletcher, H.A. ; Tanner, R. ; O'Shea, M.K. ; McShane, H. ; Fairfax, B.P. ; Knight, J.C. ; Hill, A.V. ;

EBioMedicine

Gene expression and cytokine profile correlate with mycobacterial growth in a human BCG challenge model.

Matsumiya, M. ; Satti, I. ; Chomka, A. ; Harris, S.A. ; Stockdale, L. ; Meyer, J. ; Fletcher, H.A. ; McShane, H. ;