Dr Helen Fletcher


Associate Professor
in Immunology and Director, TB Centre


Keppel Street
United Kingdom

+44 (0) 20 7927 2666

I received my PhD in Microbiology from the University of Leeds and began working in tuberculosis (TB) as a Postdoctoral Research Fellow at University College London in 1999. In 2002 I moved to the Jenner Institute, University of Oxford as an immunologist for the first-in-man trial of a new TB vaccine, MVA85A. I worked on the MVA85A vaccine through Phase I, Phase II and Phase IIb efficacy trials.  

After 10 years at the Jenner Institute I established my own research group at the London School of Hygiene & Tropical Medicine (LSHTM) where I continue my research in TB vaccines and immune correlates of risk. 

In 2015 I became Director/Deputy Director of the TB Centre at LSHTM The TB Centre brings people together from across the different Departments and Faculties of LSHTM who share a common research interest in TB.  Recognizing the value of sharing ideas and the power of a collective voice, the TB Centre provides a forum through which members can more effectively enhance their own research and influence policy. 

In 2017, I applied for and obtained funding to establish The VALIDATE Network - Vaccine development for complex intracellular neglected pathogens  This is an MRC funded Network of UK and LMIC scientists working to develop vaccines for TB, melioidosis, leishmaniasis and leprosy.  By sharing cross-pathogen, cross-discipline experience we hope to accelerate the development of vaccines for all these pathogens.  I’m co-PI of The VALIDATE Network with Helen McShane at the university of Oxford.

I’m also part of the Bill and Melinda Gates Foundation sponsored “Collaboration for TB Vaccine Development (CTVD)”  In 2016 I become co-chair of the “Conventional T-cell Community” within the CTVD. This a community of global experts in cellular immunology who discuss and identify the major challenges and key experiments needed to develop more effective T cell inducing vaccines for protection against TB.


Faculty of Infectious and Tropical Diseases
Department of Immunology and Infection


Tuberculosis (TB) Centre
Vaccine Centre


I am co-organizer of the Vaccine Immunology MSc module with and a tutor on the Distance Learning programme


Research Area
Innate immunity
T-cell immunology
Disease control
Global Health
Disease and Health Conditions
Infectious disease
Gambia, The
South Africa
Sub-Saharan Africa (all income levels)

Selected Publications

T-cell activation is an immune correlate of risk in BCG vaccinated infants.
Fletcher, H.A. ; Snowden, M.A. ; Landry, B. ; Rida, W. ; Satti, I. ; Harris, S.A. ; Matsumiya, M. ; Tanner, R. ; O'Shea, M.K. ; Dheenadhayalan, V. ; Bogardus, L. ; Stockdale, L. ; Marsay, L. ; Chomka, A. ; Harrington-Kandt, R. ; Manjaly-Thomas, Z.R. ; Naranbhai, V. ; Stylianou, E. ; Darboe, F. ; Penn-Nicholson, A. ; Nemes, E. ; Hatheril, M. ; Hussey, G. ; Mahomed, H. ; Tameris, M. ; McClain, J.B. ; Evans, T.G. ; Hanekom, W.A. ; Scriba, T.J. ; McShane, H. ;
Nat Commun
Human newborn bacille Calmette-Guérin vaccination and risk of tuberculosis disease: a case-control study.
Fletcher, H.A.; Filali-Mouhim, A.; Nemes, E.; Hawkridge, A.; Keyser, A.; Njikan, S.; Hatherill, M.; Scriba, T.J.; Abel, B.; Kagina, B.M.; Veldsman, A.; Agudelo, N.M.; Kaplan, G.; Hussey, G.D.; Sekaly, R.P.; Hanekom, W.A.; BCG study team, .; COLLABORATORS;Minnies, D. ; Tanner, R. ; Chung, C.K. ; Cameron, M.J. ; Goulet, J.P. ; Gaujoux, R. ; Hughes, J. ; Gelderbloem, S. ; Iloni, K. ; Buchanan, M. ; van der Merwe, L. ; Burger, A. ; Denation, L. ; Mlanjeni, S. ; Abrahams, S. ; Shepherd, R. ; Geldenhuys, M. ; Seoighe, C. ; Soares, A. ; Gamieldien, H. ; Sidibana, M. ; Mahomed, H. ; McShane, H. ; Hill, A.V. ;
Human biomarkers: can they help us to develop a new tuberculosis vaccine?
Fletcher, H.A. ; Dockrell, H.M. ;
Future Microbiol
Distinct Transcriptional and Anti-Mycobacterial Profiles of Peripheral Blood Monocytes Dependent on the Ratio of Monocytes: Lymphocytes.
Naranbhai, V. ; Fletcher, H.A. ; Tanner, R. ; O'Shea, M.K. ; McShane, H. ; Fairfax, B.P. ; Knight, J.C. ; Hill, A.V. ;
Gene expression and cytokine profile correlate with mycobacterial growth in a human BCG challenge model.
Matsumiya, M. ; Satti, I. ; Chomka, A. ; Harris, S.A. ; Stockdale, L. ; Meyer, J. ; Fletcher, H.A. ; McShane, H. ;
J Infect Dis
Blood monocyte-lymphocyte ratios identify adults at risk of incident tuberculosis amongst patients initiating antiretroviral therapy.
Naranbhai, V.; Hill, A.V.; Abdool Karim, S.S.; Naidoo, K.; Abdool Karim, Q.; Warimwe, G.M.; McShane, H.; Fletcher, H.;
J Infect Dis
Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans.
McShane, H. ; Pathan, A.A. ; Sander, C.R. ; Keating, S.M. ; Gilbert, S.C. ; Huygen, K. ; Fletcher, H.A. ; Hill, A.V. ;
Nat Med
See all Dr Helen Fletcher's Publications