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Professor Helen Fletcher

BSc PhD

Professor
Professor of Immunology, Global Challenges Research Fund Challenge Leader in Global Health and Director of International Development, UKRI

Room
K396

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
+44 (0) 20 7927 2361

Helen Fletcher is a Professor of Immunology at the London School of Hygiene & Tropical Medicine (LSHTM) and Director of International Development, UKRI. 

As Director of International Development Helen is responsible for the development of strategy and the delivery of the Global Challenges Research Fund (GCRF) and Newton programmes.

Helen is a research group leader at LSHTM where she continues her research in Tuberculosis (TB) vaccines and immune correlates of risk. Since 2000 She has worked with scientists across Africa in The Gambia, Zambia, Ethiopia, Senegal, Kenya, South Africa and Uganda. Helen is co- Principal Investigator of The VALIDATE Network.  An MRC/BBSRC GCRF funded Network of UK and LMIC scientists working to develop vaccines for TB, melioidosis, leishmaniasis and leprosy. Helen was Director of the TB Centre at LSHTM and in April 2018 joined UKRI on secondment as Challenge Leader in Global Health.

Helen has a Ph.D in Microbiology from the University of Leeds where she also completed her undergraduate degree. She is co-Editor of the journal Tropical Medicine and International Health and has written over 100 peer review research articles and chapters.

Affiliations

Faculty of Infectious and Tropical Diseases
Department of Infection Biology

Centres

Tuberculosis (TB) Centre
Vaccine Centre

Teaching

I am co-organizer of the Vaccine Immunology MSc module with and a tutor on the Distance Learning programme

Research

Research Area
Innate immunity
T-cell immunology
Vaccines
Disease control
Global Health
Immunisation
Discipline
Immunology
Bioinformatics
Vaccinology
Disease and Health Conditions
Infectious disease
Malaria
Tuberculosis
Country
Gambia, The
Senegal
Thailand
South Africa
Region
Sub-Saharan Africa (all income levels)

Selected Publications

T-cell activation is an immune correlate of risk in BCG vaccinated infants.
Fletcher, H.A. ; Snowden, M.A. ; Landry, B. ; Rida, W. ; Satti, I. ; Harris, S.A. ; Matsumiya, M. ; Tanner, R. ; O'Shea, M.K. ; Dheenadhayalan, V. ; Bogardus, L. ; Stockdale, L. ; Marsay, L. ; Chomka, A. ; Harrington-Kandt, R. ; Manjaly-Thomas, Z.R. ; Naranbhai, V. ; Stylianou, E. ; Darboe, F. ; Penn-Nicholson, A. ; Nemes, E. ; Hatheril, M. ; Hussey, G. ; Mahomed, H. ; Tameris, M. ; McClain, J.B. ; Evans, T.G. ; Hanekom, W.A. ; Scriba, T.J. ; McShane, H. ;
2016
Nat Commun
Human newborn bacille Calmette-Guérin vaccination and risk of tuberculosis disease: a case-control study.
Fletcher, H.A.; Filali-Mouhim, A.; Nemes, E.; Hawkridge, A.; Keyser, A.; Njikan, S.; Hatherill, M.; Scriba, T.J.; Abel, B.; Kagina, B.M.; Veldsman, A.; Agudelo, N.M.; Kaplan, G.; Hussey, G.D.; Sekaly, R.P.; Hanekom, W.A.; BCG study team, .; COLLABORATORS;Minnies, D. ; Tanner, R. ; Chung, C.K. ; Cameron, M.J. ; Goulet, J.P. ; Gaujoux, R. ; Hughes, J. ; Gelderbloem, S. ; Iloni, K. ; Buchanan, M. ; van der Merwe, L. ; Burger, A. ; Denation, L. ; Mlanjeni, S. ; Abrahams, S. ; Shepherd, R. ; Geldenhuys, M. ; Seoighe, C. ; Soares, A. ; Gamieldien, H. ; Sidibana, M. ; Mahomed, H. ; McShane, H. ; Hill, A.V. ;
2016
BMC Med
Human biomarkers: can they help us to develop a new tuberculosis vaccine?
Fletcher, H.A. ; Dockrell, H.M. ;
2016
Future Microbiol
Distinct Transcriptional and Anti-Mycobacterial Profiles of Peripheral Blood Monocytes Dependent on the Ratio of Monocytes: Lymphocytes.
Naranbhai, V. ; Fletcher, H.A. ; Tanner, R. ; O'Shea, M.K. ; McShane, H. ; Fairfax, B.P. ; Knight, J.C. ; Hill, A.V. ;
2015
EBioMedicine
Gene expression and cytokine profile correlate with mycobacterial growth in a human BCG challenge model.
Matsumiya, M. ; Satti, I. ; Chomka, A. ; Harris, S.A. ; Stockdale, L. ; Meyer, J. ; Fletcher, H.A. ; McShane, H. ;
2014
J Infect Dis
Blood monocyte-lymphocyte ratios identify adults at risk of incident tuberculosis amongst patients initiating antiretroviral therapy.
Naranbhai, V.; Hill, A.V.; Abdool Karim, S.S.; Naidoo, K.; Abdool Karim, Q.; Warimwe, G.M.; McShane, H.; Fletcher, H.;
2013
J Infect Dis
Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans.
McShane, H. ; Pathan, A.A. ; Sander, C.R. ; Keating, S.M. ; Gilbert, S.C. ; Huygen, K. ; Fletcher, H.A. ; Hill, A.V. ;
2004
Nat Med
See all Professor Helen Fletcher's Publications