Professor Paul Fine


of Communicable Disease Epidemiology

Room 103c

Keppel Street
United Kingdom

+44 (0)20 7927 2219

Paul Fine trained originally in zoology, veterinary medicine, parasitology and epidemiology, and joined the staff of LSHTM in 1976. His major methodological interests have been in infection dynamics, family studies, genetics, and the evaluation of vaccines (efficacy, adverse reactions and impact), applied to a variety of infections. Much of his earlier work concentrated upon vertical (from parent to progeny) transmission of infections and upon measles and pertussis in the UK. He directed a large epidemiological research programme (the "Karonga Prevention Study") in Malawi from 1978-2006, concentrating at first upon leprosy, then tuberculosis, and ultimately HIV, and including demographic surveillance, vaccine evaluation, and studies of other infections in a rural population in northern Malawi. Since 1997 he has worked on a wide variety of vaccine issues, including the evaluation of non-specific effects of vaccines, methods for field evaluation of veterinary vaccines, the implications of the transmissibility of oral polio vaccine viruses for the polio eradication initiative, and methods for optimising vaccination schedules.


Faculty of Epidemiology and Population Health
Department of Infectious Disease Epidemiology


He is involved in epidemiology-related teaching on several of the MSc and short courses offered by the LSHTM.


He has broad interests in infectious disease epidemiology, with particular emphasis upon vaccines (trials, safety and efficacy evaluations of BCG, measles, pertussis, mumps, polio), mycobacterial diseases (including genetics, immune responses, risk factors, vaccine and drug trials of leprosy and tuberculosis) and family studies (in the broadest sense, including both Mendelian and non-Mendelian inheritance). He directed a large study of tuberculosis, leprosy and HIV in northern Malawi (the Karonga Prevention Study) from 1978 to 2006.

Research Area
Clinical trials
Disease and Health Conditions
Infectious disease

Selected Publications

Contribution of remote M.tuberculosis infection to tuberculosis disease: A 30-year population study.
Glynn JR; Khan P; Mzembe T; Sichali L; Fine PEM; Crampin AC; Houben RMGJ
PloS one
When to update COVID-19 vaccine composition.
Grant R; Sacks JA; Abraham P; Chunsuttiwat S; Cohen C; Figueroa JP; Fleming T; Fine P; Goldblatt D; Hasegawa H
Nature medicine
Risk factors for SARS-CoV-2 infection in primary and secondary school students and staff in England in the 2020/2021 school year: a longitudinal study.
Nguipdop-Djomo P; Oswald WE; Halliday KE; Cook S; Sturgess J; Sundaram N; Warren-Gash C; Fine PE; Glynn J; Allen E
International Journal of Infectious Diseases
Genome-wide association study of leprosy in Malawi and Mali
Gilchrist JJ; Auckland K; Parks T; Mentzer AJ; Goldblatt L; Naranbhai V; Band G; Rockett KA; Toure OB; Konate S
PLoS pathogens
Epidemiology of SARS-CoV-2 infection among staff and students in a cohort of English primary and secondary schools during 2020-2021.
Hargreaves JR; Langan SM; Oswald WE; Halliday KE; Sturgess J; Phelan J; Nguipdop-Djomo P; Ford B; Allen E; Sundaram N
The Lancet Regional Health Europe
Seroepidemiology and Carriage of Diphtheria in Epidemic-Prone Area and Implications for Vaccination Policy, Vietnam
Kitamura N; Hoan TT; Do HM; Dao TA; Le LT; Le TTT; Doan TTT; Chau TN; Dinh HT; Iwaki M
Emerging infectious diseases
The seroprevalence, waning rate, and protective duration of anti-diphtheria toxoid IgG antibody in Nha Trang, Vietnam.
Kitamura N; Le LT; Le TTT; Nguyen H-AT; Edwards T; Madaniyazi L; Bui MX; Do HT; Dang D-A; Toizumi M
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
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