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Dr Abdi Elmi

BSc MSc PhD

Senior Scientific Officer
/ Microbiologist

Room
380/Laboratory 202

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
+44 (0)207 958 8391

Fax.
+44 (0)20 7927 2739

I have a Bachelor of Science degree in Microbial Biotechnology from University of Surrey, a Master of Science from Nottingham University and a Ph.D. from LSHTM. I joined the School in 2004. I am  responsible for the management of a number of ITD laboratories. I am Health and Safety Supervisor for the Department of PMB, Deputy Radiation Supervisor of the School, a member of Gene Modification Advisory Committee and Scientific Manager for Professor Brendan Wren’s research group. I also carry out research in Bacterial pathogenesis, virulence and host immune response. I maintain regular output of high quality research and publish in leading research journals contributing significantly the School's strategy and policy of submission to future Research Excellence Framework (REF) programmes.

 

 

 

 

Affiliations

Faculty of Infectious and Tropical Diseases
Department of Pathogen Molecular Biology

Teaching

I am co-organiser of Molecular Biology and Recombinant DNA Technique (Module 3333). I also deliver a range of lectures across a range of modules.

I supervise Master and Doctoral research students. Currently I am co-supervisor of one PhD student.

I act as a Tutor for MSc students and advisor for PhD students.

Research

My research focuses characterising the role of Outer Membrane Vesicles (OMVs) in Bacterial pathogenesis. This area of research has emerged as major area and we are beginning to appreciate that OMVs have an important role in bacterial virulence.

Current projects.

  1. Characterisation of the biological functions of the different compositions of C. jejuni OMVs.
  2. Understanding of how some proteins are incorporated within the OMVs while most proteins are spared. We know little about this critical process, in contrast to our understanding of the role of OMVs in pathogenesis.
  3. Characterisation of underlying mechanisms that lead to C. jejuni OMVs interaction with IECs eventually leading to the delivering of OMVs content into the IECs cytosol. We focus on the role of C. jejuni outer membrane proteins that have been reported to be involved in adhesion, as well as with other virulence associated proteins found in the periplasm.

 

 

Research Area
Bacteria
Discipline
Genomics
Molecular epidemiology
Bacteriology
Cell biology
Genetics
Immunology
Molecular biology

Selected Publications

Increase in Campylobacter jejuni invasion of intestinal epithelial cells under low oxygen co-culture conditions that reflect the in vivo environment.
Mills, D.C.; Gundogdu, O.; Elmi, A.; Bajaj-Elliott, M.; Taylor, P.W.; Wren, B.W.; Dorrell, N.;
Infect Immun
Campylobacter jejuni outer membrane vesicles play an important role in bacterial interactions with human intestinal epithelial cells.
Elmi, A.; Watson, E.; Sandu, P.; Gundogdu, O.; Mills, D.C.; Inglis, N.F.; Manson, E.; Imrie, L.; Bajaj-Elliott, M.; Wren, B.W.; Smith, D.G.; Dorrell, N.;
Infect Immun
Campylobacter jejuni alters surface capsular polysaccharide when co-cultured with epithelial cells.
Corcionivoschi, N.; Clyne, M.; Lyons, A.; Elmi, A.; Gundogdu, O.; Wren, B.W.; Dorrell, N.; Karlyshev, A.V.; Bourke, B.;
Infect Immun
A major role for intestinal epithelial nucleotide oligomerization domain 1 (NOD1) in eliciting host bactericidal immune responses to Campylobacter jejuni.
Zilbauer M. ; Dorrell N. ; Elmi A. ; Lindley KJ. ; Schüller S. ; Jones HE. ; Klein NJ. ; Núnez G. ; Wren BW. ; Bajaj-Elliott M.
Cell Microbiol
Comparative phylogenomics of the food-borne pathogen Campylobacter jejuni reveals genetic markers predictive of infection source.
Champion, O.L.; Gaunt, M.W.; Gundogdu, O.; Elmi, A.; Witney, A.A.; Hinds, J.; Dorrell, N.; Wren, B.W.;
Proc Natl Acad Sci U S A
See all Dr Abdi Elmi's Publications