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Dr Abdi Elmi

BSc MSc PhD

Senior Scientific Officer
/ Microbiologist

Room
380/Laboratory 202

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
+44 (0)207 958 8391

I joined the School in 2004. I am Health and Safety Supervisor for the Department of PMB, Deputy Radiation Supervisor, a member of Gene Modification Advisory Committee and Scientific Manager for Professor Brendan Wren’s research team. My research focuses on some major global bacterial pathogens such Campylobacter jejuni and Clostridium difficile.

 

 

 

 

 

Affiliations

Department of Pathogen Molecular Biology
Faculty of Infectious and Tropical Diseases

Teaching

I am co-organiser of Molecular Biology and Recombinant DNA Technique (Module 3333). I also deliver a range of lectures across a range of modules.

I supervise Master and Doctoral research students. Currently I am co-supervisor of two PhD students.

I act as a Tutor for MSc students.

Research

My research focuses characterising the role of Outer Membrane Vesicles (OMVs) in Bacterial pathogenesis.

Current projects.

  1. Characterisation of the biological functions of the different compositions of C. jejuni OMVs.
  2. Understanding of how some proteins are incorporated within the OMVs while most proteins are spared. We know little about this critical process, in contrast to our understanding of the role of OMVs in pathogenesis.
  3. Characterisation of underlying mechanisms that lead to C. jejuni OMVs interaction with IECs eventually leading to the delivering of OMVs content into the IECs cytosol.

 

 

Research Area
Bacteria
Discipline
Genomics
Molecular epidemiology
Bacteriology
Cell biology
Genetics
Immunology
Molecular biology

Selected Publications

Increase in Campylobacter jejuni invasion of intestinal epithelial cells under low oxygen co-culture conditions that reflect the in vivo environment.
Mills, D.C.; Gundogdu, O.; Elmi, A.; Bajaj-Elliott, M.; Taylor, P.W.; Wren, B.W.; Dorrell, N.;
2012
Infect Immun
Campylobacter jejuni outer membrane vesicles play an important role in bacterial interactions with human intestinal epithelial cells.
Elmi, A.; Watson, E.; Sandu, P.; Gundogdu, O.; Mills, D.C.; Inglis, N.F.; Manson, E.; Imrie, L.; Bajaj-Elliott, M.; Wren, B.W.; Smith, D.G.; Dorrell, N.;
2012
Infect Immun
Campylobacter jejuni alters surface capsular polysaccharide when co-cultured with epithelial cells.
Corcionivoschi, N.; Clyne, M.; Lyons, A.; Elmi, A.; Gundogdu, O.; Wren, B.W.; Dorrell, N.; Karlyshev, A.V.; Bourke, B.;
2009
Infect Immun
A major role for intestinal epithelial nucleotide oligomerization domain 1 (NOD1) in eliciting host bactericidal immune responses to Campylobacter jejuni.
Zilbauer M. ; Dorrell N. ; Elmi A. ; Lindley KJ. ; Schüller S. ; Jones HE. ; Klein NJ. ; Núnez G. ; Wren BW. ; Bajaj-Elliott M.
2007
Cell Microbiol
Comparative phylogenomics of the food-borne pathogen Campylobacter jejuni reveals genetic markers predictive of infection source.
Champion, O.L.; Gaunt, M.W.; Gundogdu, O.; Elmi, A.; Witney, A.A.; Hinds, J.; Dorrell, N.; Wren, B.W.;
2005
Proc Natl Acad Sci U S A
See all Dr Abdi Elmi's Publications