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Professor Alison Elliott

MA MBBS MD DTM&H FRCP FAAS

Professor
of Tropical Medicine

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
0207 927 2116

Alison Elliott is a physician, specialising in infectious diseases and tropical medical research.  After a degree in Natural Sciences and medical training in the UK she went to Zambia in 1988, and undertook early studies on the interaction between tuberculosis and HIV infection.  Between 1992 and 1995 she undertook an infectious diseases fellowship in the USA, with research on the immunology of tuberculosis at the National Jewish Center in Denver, Colorado.  Since 1996 she has been working in Uganda, supported by Wellcome Trust and MRC funding, at the Medical Research Council / Uganda Virus Research Institute (UVRI) and LSHTM Uganda Research Unit, where she is Theme Leader for Vaccines and Immunity and Head of the Immunomodulation and Vaccines Programme.

Affiliations

Department of Clinical Research
Faculty of Infectious and Tropical Diseases

Centres

TB Centre
Vaccine Centre

Teaching

Alison's main "teaching" activity is in research capacity building in Uganda.  She currently leads the Wellcome Trust funded Makerere-UVRI Centre of Excellence for Infection and Immunity Research and Training (MUII; www.muii.org.ug) which aims to attract bright young Ugandans to develop an internationally competitive research career in the field of Infection and Immunity.  This programme is a collaboration between the Uganda Virus Research Institute, Makerere University, LSHTM and Cambridge University (with many other, much-valued, regional and international partners).  Activities include Open Days for schools, undergraduate internships, and a Masters, PhD and post-doctoral fellowship scheme; as well as a flagship short course in Immunology (Immunology in the Tropics) and a series of Hot Topics seminars presented by scientists who are world leaders in their fields as they visit Uganda.

Research

Alison's research interests focus on the immuno-modulating effects of chronic infections.  After early studies on HIV and tuberculosis she developed an interest in the immuno-modulating effects of helminths.  Current research particularly addresses the effects of early life exposures on outcomes in adolescence, based on the Entebbe Mother and Baby Study birth cohort (www.emabs.lshtm.ac.uk).  The team has also completed a cluster-randomised trial among fishing villages in the islands of Lake Victoria, Uganda, investigating the effects of standard, versus intenstive, intervention against helminth infections on responses to vaccines, to microbial pathogens and to allergens; and has embarked on a series of new trials investigating the role and reversibility of immunodulating parasitic infections in population differences in vaccines responses.

Research Area
Child health
Clinical trials
Helminths
Adolescent health
Capacity strengthening
Discipline
Immunoepidemiology
Life-course epidemiology
Epidemiology
Immunology
Medicine
Vaccinology
Disease and Health Conditions
Tuberculosis
Allergy
Asthma
Neglected Tropical Diseases (NTDs)
Schistosomiasis
Country
Uganda
Region
Sub-Saharan Africa (developing only)

Selected Publications

High-dose oral and intravenous rifampicin for the treatment of tuberculous meningitis in predominantly HIV-positive Ugandan adults: a phase II open-label randomised controlled trial.
Cresswell FV; Meya DB; Kagimu E; Grint D; Te Brake L; Kasibante J; Martyn E; Rutakingirwa M; Quinn CM; Okirwoth M
2021
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Immunological Considerations for <i>Schistosoma</i> Vaccine Development: Transitioning to Endemic Settings.
Driciru E; Koopman JPR; Cose S; Siddiqui AA; Yazdanbakhsh M; Elliott AM; Roestenberg M
2021
Frontiers in immunology
Malaria is a cause of iron deficiency in African children.
Muriuki JM; Mentzer AJ; Mitchell R; Webb EL; Etyang AO; Kyobutungi C; Morovat A; Kimita W; Ndungu FM; Macharia AW
2021
Nature medicine
BCG-induced non-specific effects on heterologous infectious disease in Ugandan neonates: an investigator-blind randomised controlled trial.
Prentice S; Nassanga B; Webb EL; Akello F; Kiwudhu F; Akurut H; Elliott AM; Arts RJW; Netea MG; Dockrell HM
2021
The Lancet. Infectious diseases
Maternal Latent Mycobacterium tuberculosis Does Not Affect the Infant Immune Response Following BCG at Birth: An Observational Longitudinal Study in Uganda.
Lubyayi L; Mawa PA; Nabakooza G; Nakibuule M; Tushabe JV; Serubanja J; Aibo D; Akurut H; Tumusiime J; Hasso-Agopsowicz M
2020
FRONTIERS IN IMMUNOLOGY
Cross-reactive carbohydrate determinant-specific IgE obscures true atopy and exhibits ⍺-1,3-fucose epitope-specific inverse associations with asthma.
Nkurunungi G; Mpairwe H; Versteeg SA; van Diepen A; Nassuuna J; Kabagenyi J; Nambuya I; Sanya RE; Nampijja M; Serna S
2020
Allergy
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