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Professor Alison Elliott

MA MBBS MD DTM&H FRCP FAAS

Professor
of Tropical Medicine

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
0207 927 2116

Alison Elliott is a physician, specialising in infectious diseases and tropical medical research.  After a degree in Natural Sciences and medical training in the UK she went to Zambia in 1988, and undertook early studies on the interaction between tuberculosis and HIV infection.  Between 1992 and 1995 she undertook an infectious diseases fellowship in the USA, with research on the immunology of tuberculosis at the National Jewish Center in Denver, Colorado.  Since 1996 she has been working in Uganda, supported by Wellcome Trust and MRC funding, at the Medical Research Council / Uganda Virus Research Institute (UVRI) and LSHTM Uganda Research Unit, where she is Theme Leader for Vaccines and Immunity and Head of the Immunomodulation and Vaccines Programme.

Affiliations

Department of Clinical Research
Faculty of Infectious and Tropical Diseases

Centres

Tuberculosis (TB) Centre
Vaccine Centre

Teaching

Alison's main "teaching" activity is in research capacity building in Uganda.  She currently leads the Wellcome Trust funded Makerere-UVRI Centre of Excellence for Infection and Immunity Research and Training (MUII; www.muii.org.ug) which aims to attract bright young Ugandans to develop an internationally competitive research career in the field of Infection and Immunity.  This programme is a collaboration between the Uganda Virus Research Institute, Makerere University, LSHTM and Cambridge University (with many other, much-valued, regional and international partners).  Activities include Open Days for schools, undergraduate internships, and a Masters, PhD and post-doctoral fellowship scheme; as well as a flagship short course in Immunology (Immunology in the Tropics) and a series of Hot Topics seminars presented by scientists who are world leaders in their fields as they visit Uganda.

Research

Alison's research interests focus on the immuno-modulating effects of chronic infections.  After early studies on HIV and tuberculosis she developed an interest in the immuno-modulating effects of helminths.  Current research particularly addresses the effects of early life exposures on outcomes in adolescence, based on the Entebbe Mother and Baby Study birth cohort (www.emabs.lshtm.ac.uk).  The team has also completed a cluster-randomised trial among fishing villages in the islands of Lake Victoria, Uganda, investigating the effects of standard, versus intenstive, intervention against helminth infections on responses to vaccines, to microbial pathogens and to allergens; and has embarked on a series of new trials investigating the role and reversibility of immunodulating parasitic infections in population differences in vaccines responses.

Research Area
Child health
Clinical trials
Helminths
Adolescent health
Capacity strengthening
Discipline
Immunoepidemiology
Life-course epidemiology
Epidemiology
Immunology
Medicine
Vaccinology
Disease and Health Conditions
Tuberculosis
Allergy
Asthma
Neglected Tropical Diseases (NTDs)
Schistosomiasis
Country
Uganda
Region
Sub-Saharan Africa (developing only)

Selected Publications

Xpert MTB/RIF Ultra for the diagnosis of HIV-associated tuberculous meningitis: a prospective validation study.
Cresswell FV; Tugume L; Bahr NC; Kwizera R; Bangdiwala AS; Musubire AK; Rutakingirwa M; Kagimu E; Nuwagira E; Mpoza E
2020
The Lancet. Infectious diseases
Risk assessment for the implementation of controlled human Schistosoma mansoni infection trials in Uganda
Koopman JP; Egesa M; Wajja A; Adriko M; Nassuuna J; Nkurunungi G; Driciru E; van Willigen G; Cose S; Yazdanbakhsh M
2019
AAS Open Research
The effect of helminth infections and their treatment on metabolic outcomes: results of a cluster-randomised trial.
Sanya RE; Webb EL; Zziwa C; Kizindo R; Sewankambo M; Tumusiime J; Nakazibwe E; Oduru G; Niwagaba E; Kabuubi Nakawungu P
2019
Clinical infectious diseases
Asthma control and management among schoolchildren in urban Uganda: results from a cross-sectional study
Mpairwe H; Tumwesige P; Namutebi M; Nnaluwooza M; Katongole T; Tumusiime J; Apule B; Onen C; Mukasa M; Kahwa J
2019
Wellcome Open Research
Kaposi's sarcoma-associated herpesvirus seropositivity is associated with parasite infections in Ugandan fishing communities on Lake Victoria islands.
Nalwoga A; Webb EL; Chihota B; Miley W; Walusimbi B; Nassuuna J; Sanya RE; Nkurunungi G; Labo N; Elliott AM
2019
PLoS neglected tropical diseases
The ferroportin Q248H mutation protects from anemia, but not malaria or bacteremia
Muriuki JM; Mentzer AJ; Band G; Gilchrist JJ; Carstensen T; Lule SA; Goheen MM; Joof F; Kimita W; Mogire R
2019
Science Advances
A genome‐wide association and replication study of blood pressure in Ugandan early adolescents
Lule SA; Mentzer AJ; Namara B; Muwenzi AG; Nassanga B; Kizito D; Akurut H; Lubyayi L; Tumusiime J; Zziwa C
2019
Molecular Genetics & Genomic Medicine
Risk factors for asthma among schoolchildren who participated in a case-control study in urban Uganda.
Mpairwe H; Namutebi M; Nkurunungi G; Tumwesige P; Nambuya I; Mukasa M; Onen C; Nnaluwooza M; Apule B; Katongole T
2019
eLife
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