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Prof Isabel Dos Santos Silva

Professor of Epidemiology

United Kingdom

Tel.
+44 (0) 20 7927 2113

I have a Medical degree from the Universidade Classica de Lisbon (Portugal), and a PhD in Epidemiology from the University of London.

I joined the School in 1989.

Affiliations

Department of Non-communicable Disease Epidemiology
Faculty of Epidemiology and Population Health

Centres

Centre for Data and Statistical Science for Health

Teaching

I teach in a large number of MSc courses including both the in-house and the distance learning (DL) MSc Epidemiology courses. Currently, I co-organise the in-house module on the Epidemiology of Non-Communicable Diseases (ENCD).

I have taught in a large number of courses overseas including various international courses on cancer epidemiology in Africa, Asia, Latin America and the Middle East organised by the International Agency for Research on Cancer (IARC) and the International Epidemiological Association (IEA).

I wrote the first edition of the textbook "Cancer Epidemiology: Principles and Methods". A second edition is currently being prepared.

I have successfully supervised several MSc and PhD students over the years.

Research

Most of my research focus on cancer epidemiology and control, with studies being conducted in high-income countries as well as in low- and middle-income countries. A few illustrative examples of this work:

- Jointly with Dr. Valerie McCormack (from the International Agency for Research on Cancer, IARC/WHO) and other colleagues, I am conducting a multi-country study to investigate proximal and distal determinants of survival from breast cancer in sub-Saharan Africa (SSA). This study was initially funded by Susan G Komen and, more recently, by the US National Cancer Institute (NCI). This large multi-centric study has led to several seminal publications on disparities in survival after a breast cancer diagnosis in SSA and their man drivers.

- In collaboration with colleagues in Brazil we have investigated ethnic and socio-economic disparities in the prevalence of breast cancers diagnosed at a late (advanced) stage when prognosis is poorer and effective treatment options limited. We have also investigated the joint effects of race and socio-economic disadvantage on mortality from breast and cervical cancer within the Brazilian 100 million cohort.

This work is underpinned by a large number of collaborations both in the United Kingdom and overseas.

Selected Publications

Ethnoracial and social trends in breast cancer staging at diagnosis in Brazil, 2001–14: a case only analysis
DOS-SANTOS-SILVA, I; De Stavola, BL; Renna, NL; Nogueira, MC; Aquino, EM L; Bustamante-Teixeira, MT; Azevedo e Silva, G;
2019
The Lancet Global Health
Association of BMI with overall and cause-specific mortality: a population-based cohort study of 3·6 million adults in the UK.
BHASKARAN, K; DOS-SANTOS-SILVA, I; LEON, DA; DOUGLAS, IJ; SMEETH, L;
2018
The lancet. Diabetes & endocrinology
Cost-effectiveness of breast cancer screening programme for women in rural China.
SUN, L; SADIQUE, Z; DOS-SANTOS-SILVA, I; Yang, L; LEGOOD, R;
2018
International journal of cancer Journal international du cancer
Growth Trajectories, Breast Size, and Breast-Tissue Composition in a British Prebirth Cohort of Young Women.
DENHOLM, R; De Stavola, B; Hipwell, JH; Doran, SJ; BUSANA, MC; Leach, MO; Hawkes, DJ; DOS-SANTOS-SILVA, I;
2017
American journal of epidemiology
Mammographic density and ageing: A collaborative pooled analysis of cross-sectional data from 22 countries worldwide.
Burton, A; Maskarinec, G; Perez-Gomez, B; Vachon, C; Miao, H; Lajous, M; López-Ridaura, R; Rice, M; Pereira, A; Garmendia, ML; Tamimi, RM; Bertrand, K; Kwong, A; Ursin, G; Lee, E; Qureshi, SA; Ma, H; Vinnicombe, S; Moss, S; Allen, S; Ndumia, R; Vinayak, S; Teo, S-H; Mariapun, S; Fadzli, F; ... McCormack, V.
2017
PLoS medicine
Stage at diagnosis of breast cancer in sub-Saharan Africa: a systematic review and meta-analysis.
JEDY-AGBA, E; McCormack, V; Adebamowo, C; DOS-SANTOS-SILVA, I;
2016
The Lancet Global health
African Breast Cancer-Disparities in Outcomes (ABC-DO): protocol of a multicountry mobile health prospective study of breast cancer survival in sub-Saharan Africa.
McKenzie, F; Zietsman, A; Galukande, M; Anele, A; Adisa, C; Cubasch, H; Parham, G; Anderson, BO; Abedi-Ardekani, B; Schuz, J; DOS SANTOS SILVA, I; McCormack, V;
2016
BMJ open
Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5·24 million UK adults.
BHASKARAN, K; DOUGLAS, I; FORBES, H; DOS-SANTOS-SILVA, I; LEON, DA; SMEETH, L;
2014
Lancet
Circulating levels of coagulation and inflammation markers and cancer risks: individual participant analysis of data from three long-term cohorts.
DOS SANTOS SILVA, I; De Stavola, BL; Pizzi, C; MEADE, TW;
2010
International journal of epidemiology
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