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Dr Jon Cuccui

BSc MSc PhD

Associate Professor
Molecular Bacteriology

Room
Room 180

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
+44 (0) 20 7927 2813

Fax.
+44 (0) 20 7637 4314

I joined the LSHTM in 2002 as a research assistant and registered as a Ph.D. student  in Professor Brendan Wren's laboratory carrying out signature tagged mutagenesis on Burkholderia pseudomallei. My first Post Doc involved developing and utilising a novel glycoengineering method termed protein glycan coupling technology using Francisella tularensis and B. pseudomallei as the test organisms. 

 My interests are not only on the application and development of novel vaccine strategies and technologies but also on the biological reasons why bacteria carry varied glycosylation systems. 

 

Affiliations

Faculty of Infectious and Tropical Diseases
Department of Infection Biology

Centres

Vaccine Centre

Teaching

 

Ph.D. supervisor and Medical Microbiology M.Sc. lecturer, tutor, project supervisor, examiner and exam board member.

Research

My aim is to enhance our understanding of bacterial glycosylation systems and to also identify areas that may be exploited for glycoengineering purposes. I was part of a team who developed a first generation glycoconjugate vaccine against Francisella tularensis using the O-antigen repeat unit from the organism as the glycan component. I was also involved in the completion of a project attempting to characterise the capsular polysaccharide of Burkholderia pseudomallei. I maintain an interest on the work being carried out within the Wren laboratory to further understand selected mutants identified during my PhD entitled 'The development of a refined signature tagged mutagenesis strategy for the identification of novel virulence determinants and vaccine candidates in Burkholderia pseudomallei.' Recently, I have also been involved in a Transposon Directed Insertion Site sequencing project that aimed to enhance our understanding of B. pseudomallei.  

I am a former BBSRC RSE Enterprise Fellow, where I learned about the process of forming a spin out from experienced business leaders. I have a particular interest in the translational aspect of glycobiology. I am also a co-applicant on a BBSRC LoLa grant aiming to develop novel vaccines for the Poultry and ruminant markets.

Research Area
Bacteria
Vaccines
Discipline
Genetic epidemiology
Bacteriology
Genetics
Microbiology
Molecular biology
Disease and Health Conditions
Infectious disease

Selected Publications

Quantitative Analyses Reveal Novel Roles for N-Glycosylation in a Major Enteric Bacterial Pathogen.
Abouelhadid S; North SJ; Hitchen P; Vohra P; Chintoan-Uta C; Stevens M; Dell A; Cuccui J; Wren BW
2019
mBio
The N-linking glycosylation system from Actinobacillus pleuropneumoniae is required for adhesion and has potential use in glycoengineering.
Cuccui J; Terra VS; Bossé JT; Naegeli A; Abouelhadid S; Li Y; Lin CW; Vohra P; Tucker AW; Rycroft AN
2017
Open biology
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