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Professor Liz Corbett

BA MB BChir FRCP PhD FMedSci

Professor
of Tropical Epidemiology

Room
Room 363a

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
+44 (0)20 7927 2116

Fax.
+44 (0)20 7612 7860

Liz Corbett is a Wellcome Trust Senior Fellow and a Clinical Epidemiologist with the London School of Hygiene and Tropical Medicine, based full time in Blantyre, Malawi. Her main research interests concern HIV and TB in HIV prevalent populations from the public health perspective, with a focus on primary care and community level diagnostic interventions. She works closely with the World Health Organization, with previous membership of the Strategic and Technical Advisory Group for the TB Programme. Her research has highlighted the public health importance of undiagnosed infectious TB and community-level interventions providing access to TB and HIV diagnosis.  She has ongoing research in self-testing for HIV, management of cough at primary care level, TB diagnostic impact evaluations, and adolescent long-term survivors of mother-to-child transmission of HIV infection.

Affiliations

Faculty of Infectious and Tropical Diseases
Department of Clinical Research

Centres

Tuberculosis (TB) Centre

Teaching

Liz contributes to the DBL MSc in Infectious Diseases, but does not teach face-to-face in London.

Research

My main research interests is in implementation research, exploring novel public health strategies with potential to increase access to HIV and TB diagnosis and treatment with focus on community-level and primary care diagnostic intervention trials.  

I have evaluated community-based intensified TB case-finding with promising results in both Zimbabwe and Malawi, using periodic outreach with brief enquiry for chronic cough at household level.  I am currently evaluating the impact of this strategy on undiagnosed infectious TB and TB infection among children in Blantyre, Malawi. At primary care and inpatient level, I have a number of ongoing individually- and cluster-randomised TB intervention trials with colleagues in London School, LSTMed and Malawi College of Medicine and National TB Programme, investigating health outcomes from different strategies for identifying and managing patients with underlying TB. 

I have a major theme of research around HIV self-testing, having conducted a first-of-a-kind trial in 2012-14 in Malawi, the first evaluation of promotion of HIV self-testing, globally.  This proved highly successful, with high uptake, accuracy, safety and increased demand for HIV treatment, and has been taken forward for scale up in a large implementation project funded by UNITAID.  I am the Research Director for the UNITAID Population Services International HIV Self-Testing Africa (STAR) project, which has intensive research including cluster-randomised trials in Malawi (MLW), Zambia (ZAMBART), Zimbabwe (CeSHHAR), and South Africa (AHRI), as well as WHO, UCL and LSTMed as a policy and research partners. STAR has already had major impact on global policy and practice.  

Within London School, I have a long-established relationship with the Tropical Epidemiology Group, and share a number of projects and PhD students with Katherine Fielding.  I work closely with Fern Terris-Prestholt for the STAR health economics research.  I have work on masculinity and TB that bridges qualitative research, epidemiology and mathematical model with Richard White, and I have a long-standing collaboration with my clinical colleague, Rashida Ferrand, concerning adolescent long-term survivors of perinatal HIV infection in Southern Africa. 

Research Area
Clinical trials
Complex interventions
Diagnostics
Economic evaluation
Health outcomes
Health policy
Health promotion
Primary care
Public health
Adolescent health
Disease control
Evaluation
Global Health
Impact evaluation
Implementation research
Randomised controlled trials
Modelling
Discipline
Epidemiology
Medicine
Operational research
Disease and Health Conditions
HIV/AIDS
Infectious disease
Tuberculosis
Country
Malawi
South Africa
Zambia
Zimbabwe
Region
Sub-Saharan Africa (developing only)

Selected Publications

Acceptability of woman-delivered HIV self-testing to the male partner, and additional interventions: a qualitative study of antenatal care participants in Malawi.
Choko, A.T. ; Kumwenda, M.K. ; Johnson, C.C. ; Sakala, D.W. ; Chikalipo, M.C. ; Fielding, K. ; Chikovore, J. ; Desmond, N. ; Corbett, E.L. ;
2017
J Int AIDS Soc
Cost-Effectiveness of Community-based Human Immunodeficiency Virus Self-Testing in Blantyre, Malawi
Maheswaran, H. ; Clarke, A. ; MacPherson, P. ; Kumwenda, F. ; Lalloo, D.G. ; Corbett, E.L. ; Petrou, S. ;
2017
Clin Infect Dis
Scaling up HIV self-testing in sub-Saharan Africa: a review of technology, policy and evidence.
Indravudh, P.P. ; Choko, A.T. ; Corbett, E.L. ;
2017
Curr Opin Infect Dis
Sex Differences in Tuberculosis Burden and Notifications in Low- and Middle-Income Countries: A Systematic Review and Meta-analysis.
Horton, K.C. ; MacPherson, P. ; Houben, R.M. ; White, R.G. ; Corbett, E.L. ;
2016
PLoS Med
Uptake, Accuracy, Safety, and Linkage into Care over Two Years of Promoting Annual Self-Testing for HIV in Blantyre, Malawi: A Community-Based Prospective Study.
Choko, A.T. ; MacPherson, P. ; Webb, E.L. ; Willey, B.A. ; Feasy, H. ; Sambakunsi, R. ; Mdolo, A. ; Makombe, S.D. ; Desmond, N. ; Hayes, R. ; Maheswaran, H. ; Corbett, E.L. ;
2015
PLoS Med
A trial of mass isoniazid preventive therapy for tuberculosis control.
Churchyard, G.J. ; Fielding, K.L. ; Lewis, J.J. ; Coetzee, L. ; Corbett, E.L. ; Godfrey-Faussett, P. ; Hayes, R.J. ; Chaisson, R.E. ; Grant, A.D. ; Thibela TB Study Team, . ;
2014
N Engl J Med
Effect of Optional Home Initiation of HIV Care Following HIV Self-testing on Antiretroviral Therapy Initiation Among Adults in Malawi: A Randomized Clinical Trial.
MacPherson, P. ; Lalloo, D.G. ; Webb, E.L. ; Maheswaran, H. ; Choko, A.T. ; Makombe, S.D. ; Butterworth, A.E. ; van Oosterhout, J.J. ; Desmond, N. ; Thindwa, D. ; Squire, S.B. ; Hayes, R.J. ; Corbett, E.L. ;
2014
JAMA
Comparison of two active case-finding strategies for community-based diagnosis of symptomatic smear-positive tuberculosis and control of infectious tuberculosis in Harare, Zimbabwe (DETECTB): a cluster-randomised trial.
Corbett, E.L.; Bandason, T.; Duong, T.; Dauya, E.; Makamure, B.; Churchyard, G.J.; Williams, B.G.; Munyati, S.S.; Butterworth, A.E.; Mason, P.R.; Mungofa, S.; Hayes, R.J.;
2010
Lancet
See all Professor Liz Corbett's Publications