Professor David Conway

BSc PhD

Professor

of Biology

Room

Room 313

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.

+44 (0) 20 7927 2331

Fax.

+44 (0) 20 7636 8739

Email
David

David runs a research group in London conducting population genetic, experimental and epidemiological studies of malaria parasites. He works with colleagues in several countries in West Africa, as well as Kenya and Malaysia. He was based in The Gambia for several years where he also studied other aspects of malaria, and has previously worked on other infectious diseases including trachoma and strongyloidiasis. He has published over 170 research articles (Google Scholar Citations).

Affiliations

Faculty of Infectious and Tropical Diseases

Department of Pathogen Molecular Biology

Centres

Malaria Centre

Vaccine Centre

Teaching

David co-ordinates an MSc module on 'Pathogen Genomics' in the Summer Term. He previously developed an MSc module entitled 'Genetics of Pathogens and Vectors' and ran this for 9 years, and has also taught on the Study Units 'Genetic Epidemiology', and 'Immunology of Parasitic Infections', and on the Distance Learning module on Malaria. He has taught externally at UCL and on two BBSRC residential Summer Schools. He has supervised MSc research projects at LSHTM, and supervised BSc projects of students from Imperial College, UCL, and Guy's Hospital. He currently supervises 2 PhD students, and has previously supervised 10 PhDs at LSHTM and co-supervised 4 registered elsewhere.

Research

David leads a research group with a focus on malaria, and is particularly interested in: (i) the effects of natural selection on parasite antigens that are the targets of protective immune responses, (ii) naturally acquired immune responses and their relevance to protection, (iii) the effects of different epidemiological situations on parasite population genetic structures, (iv) erythrocyte invasion phenotypes of merozoites.

His research is currently funded by an ERC Advanced Award for 'Parasite population genomics and functinal studies towards development of a blood stage malaria vaccine' and a Royal Society-Leverhulme Trust award with Dr Gordon Awandare on 'Targets and patterns of erythrocyte invasion inhibitory antibody responses in malaria'. He has previously held 15 other research grants at LSHTM (8 from the Wellcome Trust, 4 from the MRC, 2 from the EU, and 1 from the Royal Society-Leverhulme Trust).

Between 2005 and 2010 he was Head of the Malaria Research Programme at the MRC Laboratories in The Gambia, where he led work supported by grants from the MRC and several other funders.

Research Area

Parasites

Vaccines

Protozoa

Discipline

Genomics

Molecular epidemiology

Epidemiology

Genetics

Immunology

Parasitology

Disease and Health Conditions

Infectious disease

Malaria

Country

Ghana

Guinea

Gambia, The

Kenya

Mali

Mauritania

Malaysia

Senegal

Selected Publications

Admixture in Humans of Two Divergent Plasmodium knowlesi Populations Associated with Different Macaque Host Species.

Divis, P.C. ; Singh, B. ; Anderios, F. ; Hisam, S. ; Matusop, A. ; Kocken, C.H. ; Assefa, S.A. ; Duffy, C.W. ; Conway, D.J. ;

PLoS Pathog

Population genomic structure and adaptation in the zoonotic malaria parasite Plasmodium knowlesi.

Assefa, S.; Lim, C.; Preston, M.D.; Duffy, C.W.; Nair, M.B.; Adroub, S.A.; Kadir, K.A.; Goldberg, J.M.; Neafsey, D.E.; Divis, P.; Clark, T.G.; Duraisingh, M.T.; Conway, D.J.; Pain, A.; Singh, B.;

Proc Natl Acad Sci U S A

Changes in malaria parasite drug resistance in an endemic population over a 25-year period with resulting genomic evidence of selection.

Nwakanma, D.C.; Duffy, C.W.; Amambua-Ngwa, A.; Oriero, E.C.; Bojang, K.A.; Pinder, M.; Drakeley, C.J.; Sutherland, C.J.; Milligan, P.J.; Macinnis, B.; Kwiatkowski, D.P.; Clark, T.G.; Greenwood, B.M.; Conway, D.J.;

J Infect Dis

Genome-wide analysis of selection on the malaria parasite Plasmodium falciparum in West African populations of differing infection endemicity.

Mobegi, V.A. ; Duffy, C.W. ; Amambua-Ngwa, A. ; Loua, K.M. ; Laman, E. ; Nwakanma, D.C. ; Macinnis, B. ; Aspeling-Jones, H. ; Murray, L. ; Clark, T.G. ; Kwiatkowski, D.P. ; Conway, D.J. ;

Mol Biol Evol

Breakdown in the Process of Incipient Speciation in Anopheles gambiae.

Nwakanma, D.C. ; Neafsey, D.E. ; Jawara, M. ; Adiamoh, M. ; Lund, E. ; Rodrigues, A. ; Loua, K.M. ; Konate, L. ; Sy, N. ; Dia, I. ; Awolola, T.S. ; Muskavitch, M.A. ; Conway, D.J. ;

Genetics

Analysis of antibodies to newly described Plasmodium falciparum merozoite antigens supports MSPDBL2 as a predicted target of naturally acquired immunity.

Tetteh, K.K.; Osier, F.H.; Salanti, A.; Kamuyu, G.; Drought, L.; Failly, M.; Martin, C.; Marsh, K.; Conway, D.J.;

Infect Immun

Population genomic scan for candidate signatures of balancing selection to guide antigen characterization in malaria parasites.

Amambua-Ngwa, A. ; Tetteh, K.K. ; Manske, M. ; Gomez-Escobar, N. ; Stewart, L.B. ; Deerhake, M.E. ; Cheeseman, I.H. ; Newbold, C.I. ; Holder, A.A. ; Knuepfer, E. ; Janha, O. ; Jallow, M. ; Campino, S. ; Macinnis, B. ; Kwiatkowski, D.P. ; Conway, D.J. ;

PLoS Genet

Erythrocyte Invasion and Merozoite Ligand Gene Expression in Severe and Mild Plasmodium falciparum Malaria

Gomez-Escobar, N.; Amambua-Ngwa, A.; Walther, M.; Okebe, J.; Ebonyi, A.; Conway, D.J.

Journal of Infectious Diseases

See all Professor David Conway's Publications

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