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Professor David Conway

BSc PhD dipABRSM

Professor
of Biology

Room
313

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
+44 (0) 20 7927 2331

Fax.
+44 (0) 20 7636 8739

Associate Dean (Research) of ITD Faculty. David runs a research group conducting population genetic, experimental and epidemiological studies of malaria parasites. Based in London, he also works with colleagues in several countries in West Africa, as well as in Malaysia. He has served as Head of Department and was previously Head of Malaria Research Programme at the MRC Unit in The Gambia where he studied many aspects of the disease in relation to natural infection and transmission. Prior to that he also worked on other infectious diseases including trachoma and strongyloidiasis. He studied at the University of Nottingham and University of Edinburgh, and worked at Imperial College London before joining LSHTM. He has published over 200 research articles (Google Scholar Citations).

 

Affiliations

Department of Infection Biology
Faculty of Infectious and Tropical Diseases

Centres

Malaria Centre
Vaccine Centre

Teaching

David co-ordinates an MSc module on 'Pathogen Genomics' in the Summer Term which has run for ten consecutive years. He previously developed an MSc module entitled 'Genetics of Pathogens and Vectors' and ran this for nine years, and has also taught on other modules, and on the Distance Learning module on Malaria. He has taught externally at UCL, at the University of Ghana, on a Wellcome-Funded overseas workshop and on BBSRC-funded residential Summer Schools. He has supervised MSc research projects at LSHTM, and supervised BSc projects of students from Imperial College, UCL, and Kings College London. He served for six years as Departmental Research Degrees Co-ordinator, and has supervised 12 PhDs at LSHTM and co-supervised 5 registered elsewhere. 

 

Research

David leads a research group with a focus on malaria, and is particularly interested in: (i) effects of natural selection on parasite targets of protective immune responses, (ii) effects of different epidemiological situations on parasite population genetic structures, including zoonotic as well as endemic transmission, (iii) naturally acquired immune responses and their relevance to protection, (iv) parasite transcriptome variation and erythrocyte invasion, (v) parasite asexual multiplication rates, (vi) parasite sexual commitment rate variation.

He is based in London, and has has spent considerable time overseas including six years as Head of the Malaria Research Programme at the MRC Laboratories in The Gambia, where he led work supported by grants from the MRC and several other funders. He has held 17 research grants at LSHTM (8 from the Wellcome Trust, 4 from the MRC, 3 from the EU including one from the ERC, and 2 from the Royal Society-Leverhulme Trust), 2 of which are current. 

Research Area
Parasites
Vaccines
Protozoa
Discipline
Genomics
Molecular epidemiology
Epidemiology
Genetics
Immunology
Parasitology
Disease and Health Conditions
Infectious disease
Malaria
Country
Ghana
Guinea
Gambia
Kenya
Mali
Mauritania
Malaysia
Senegal

Selected Publications

Highly Variable Expression of Merozoite Surface Protein MSPDBL2 in Diverse Plasmodium falciparum Clinical Isolates and Transcriptome Scans for Correlating Genes.
Hocking SE; Stewart LB; Freville A; Reid AJ; Tarr SJ; Tetteh KKA; Flueck C; Ahouidi AD; Amambua-Ngwa A; Diakite M
2022
mBio
Plasmodium falciparum Sexual Commitment Rate Variation among Clinical Isolates and Diverse Laboratory-Adapted Lines.
Stewart LB; Freville A; Voss TS; Baker DA; Awandare GA; Conway DJ
2022
Microbiology spectrum
Malaria protection due to sickle haemoglobin depends on parasite genotype.
Band G; Leffler EM; Jallow M; Sisay-Joof F; Ndila CM; Macharia AW; Hubbart C; Jeffreys AE; Rowlands K; Nguyen T
2021
Nature
A heat-shock response regulated by the PfAP2-HS transcription factor protects human malaria parasites from febrile temperatures.
Tintó-Font E; Michel-Todó L; Russell TJ; Casas-Vila N; Conway DJ; Bozdech Z; Llinás M; Cortés A
2021
Nature microbiology
Population Genomic Structure and Recent Evolution of Plasmodium knowlesi, Peninsular Malaysia.
Hocking SE; Divis PCS; Kadir KA; Singh B; Conway DJ
2020
EMERGING INFECTIOUS DISEASES
Intrinsic multiplication rate variation and plasticity of human blood stage malaria parasites.
Stewart LB; Diaz-Ingelmo O; Claessens A; Abugri J; Pearson RD; Goncalves S; Drury E; Kwiatkowski DP; Awandare GA; Conway DJ
2020
COMMUNICATIONS BIOLOGY
Modelling pathogen load dynamics to elucidate mechanistic determinants of host-Plasmodium falciparum interactions.
Georgiadou A; Lee HJ; Walther M; van Beek AE; Fitriani F; Wouters D; Kuijpers TW; Nwakanma D; D'Alessandro U; Riley EM
2019
Nature microbiology
Multi-population genomic analysis of malaria parasites indicates local selection and differentiation at the gdv1 locus regulating sexual development.
Duffy CW; Amambua-Ngwa A; Ahouidi AD; Diakite M; Awandare GA; Ba H; Tarr SJ; Murray L; Stewart LB; D'Alessandro U
2018
Scientific reports
Integrated pathogen load and dual transcriptome analysis of systemic host-pathogen interactions in severe malaria.
Lee HJ; Georgiadou A; Walther M; Nwakanma D; Stewart LB; Levin M; Otto TD; Conway DJ; Coin LJ; Cunnington AJ
2018
Science translational medicine
Schizont transcriptome variation among clinical isolates and laboratory-adapted clones of the malaria parasite Plasmodium falciparum.
Tarr SJ; Díaz-Ingelmo O; Stewart LB; Hocking SE; Murray L; Duffy CW; Otto TD; Chappell L; Rayner JC; Awandare GA
2018
BMC GENOMICS
Culture adaptation of malaria parasites selects for convergent loss-of-function mutants.
Claessens A; Affara M; Assefa SA; Kwiatkowski DP; Conway DJ
2017
Scientific reports
Three Divergent Subpopulations of the Malaria Parasite Plasmodium knowlesi.
Divis PCS; Lin LC; Rovie-Ryan JJ; Kadir KA; Anderios F; Hisam S; Sharma RSK; Singh B; Conway DJ
2017
Emerging infectious diseases
Population genetic structure and adaptation of malaria parasites on the edge of endemic distribution.
Duffy CW; Ba H; Assefa S; Ahouidi AD; Deh YB; Tandia A; Kirsebom FCM; Kwiatkowski DP; Conway DJ
2017
Molecular ecology
Resistance to malaria through structural variation of red blood cell invasion receptors.
Leffler EM; Band G; Busby GBJ; Kivinen K; Le QS; Clarke GM; Bojang KA; Conway DJ; Jallow M; Sisay-Joof F
2017
Science (New York, NY)
Multiplication rate variation in the human malaria parasite Plasmodium falciparum.
Murray L; Stewart LB; Tarr SJ; Ahouidi AD; Diakite M; Amambua-Ngwa A; Conway DJ
2017
Scientific reports
Population genomic structure and adaptation in the zoonotic malaria parasite Plasmodium knowlesi.
Assefa S; Lim C; Preston MD; Duffy CW; Nair MB; Adroub SA; Kadir KA; Goldberg JM; Neafsey DE; Divis P
2015
Proceedings of the National Academy of Sciences of the United States of America
Admixture in Humans of Two Divergent Plasmodium knowlesi Populations Associated with Different Macaque Host Species.
Divis PCS; Singh B; Anderios F; Hisam S; Matusop A; Kocken CH; Assefa SA; Duffy CW; Conway DJ
2015
PLoS pathogens
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