Close

Professor David Conway

BSc PhD

Professor
of Biology

Room
Room 313

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
+44 (0) 20 7927 2331

Fax.
+44 (0) 20 7636 8739

David runs a research group in London conducting population genetic, experimental and epidemiological studies of malaria parasites. He works with colleagues in several countries in West Africa, as well as Kenya and Malaysia. He was based in The Gambia for several years where he also studied other aspects of malaria, and has previously worked on other infectious diseases including trachoma and strongyloidiasis. He has published over 190 research articles (Google Scholar Citations).

 

Affiliations

Department of Infection Biology
Faculty of Infectious and Tropical Diseases

Centres

Malaria Centre
Vaccine Centre

Teaching

David co-ordinates an MSc module on 'Pathogen Genomics' in the Summer Term. He previously developed an MSc module entitled 'Genetics of Pathogens and Vectors' and ran this for 9 years, and has also taught on the Study Units 'Genetic Epidemiology', and 'Immunology of Parasitic Infections', and on the Distance Learning module on Malaria. He has taught externally at UCL and on two BBSRC residential Summer Schools. He has supervised MSc research projects at LSHTM, and supervised BSc projects of students from Imperial College, UCL, and Guy's Hospital. He has supervised 12 PhDs at LSHTM and co-supervised 5 registered elsewhere. 

 

Research

David leads a research group with a focus on malaria, and is particularly interested in: (i) the effects of natural selection on parasite antigens that are the targets of protective immune responses, (ii) the effects of different epidemiological situations on parasite population genetic structures, (iii) naturally acquired immune responses and their relevance to protection, (iv) erythrocyte invasion phenotypes of merozoites.

He is based in London, and has has spent considerable time overseas including six years as Head of the Malaria Research Programme at the MRC Laboratories in The Gambia, where he led work supported by grants from the MRC and several other funders. He has held 17 research grants at LSHTM (8 from the Wellcome Trust, 4 from the MRC, 3 from the EU including one from the ERC, and 2 from the Royal Society-Leverhulme Trust), 2 of which are current. 

Research Area
Parasites
Vaccines
Protozoa
Discipline
Genomics
Molecular epidemiology
Epidemiology
Genetics
Immunology
Parasitology
Disease and Health Conditions
Infectious disease
Malaria
Country
Ghana
Guinea
Gambia, The
Kenya
Mali
Mauritania
Malaysia
Senegal

Selected Publications

Modelling pathogen load dynamics to elucidate mechanistic determinants of host-Plasmodium falciparum interactions.
Georgiadou A; Lee HJ; Walther M; van Beek AE; Fitriani F; Wouters D; Kuijpers TW; Nwakanma D; D'Alessandro U; Riley EM
2019
Nature microbiology
Integrated pathogen load and dual transcriptome analysis of systemic host-pathogen interactions in severe malaria.
Lee HJ; Georgiadou A; Walther M; Nwakanma D; Stewart LB; Levin M; Otto TD; Conway DJ; Coin LJ; Cunnington AJ
2018
Science translational medicine
Multi-population genomic analysis of malaria parasites indicates local selection and differentiation at the gdv1 locus regulating sexual development.
Duffy CW; Amambua-Ngwa A; Ahouidi AD; Diakite M; Awandare GA; Ba H; Tarr SJ; Murray L; Stewart LB; D'Alessandro U
2018
Scientific reports
Schizont transcriptome variation among clinical isolates and laboratory-adapted clones of the malaria parasite Plasmodium falciparum
Tarr SJ; Diaz-Ingelmo O; Stewart LB; Hocking SE; Murray L; Duffy CW; Otto TD; Chappell L; Rayner JC; Awandare GA
2018
BMC GENOMICS
Culture adaptation of malaria parasites selects for convergent loss-of-function mutants.
Claessens A; Affara M; Assefa SA; Kwiatkowski DP; Conway DJ
2017
Scientific reports
Population genetic structure and adaptation of malaria parasites on the edge of endemic distribution.
Duffy CW; Ba H; Assefa S; Ahouidi AD; Deh YB; Tandia A; Kirsebom FC; Kwiatkowski DP; Conway DJ
2017
Molecular ecology
Three Divergent Subpopulations of the Malaria Parasite Plasmodium knowlesi.
Divis PC; Lin LC; Rovie-Ryan JJ; Kadir KA; Anderios F; Hisam S; Sharma RS; Singh B; Conway DJ
2017
Emerging infectious diseases
Resistance to malaria through structural variation of red blood cell invasion receptors.
Leffler EM; Band G; Busby GBJ; Kivinen K; Le QS; Clarke GM; Bojang KA; Conway DJ; Jallow M; Sisay-Joof F
2017
Science (New York, NY)
Multiplication rate variation in the human malaria parasite Plasmodium falciparum.
Murray L; Stewart LB; Tarr SJ; Ahouidi AD; Diakite M; Amambua-Ngwa A; Conway DJ
2017
Scientific reports
Admixture in Humans of Two Divergent Plasmodium knowlesi Populations Associated with Different Macaque Host Species.
Divis PC; Singh B; Anderios F; Hisam S; Matusop A; Kocken CH; Assefa SA; Duffy CW; Conway DJ
2015
PLoS pathogens
Population genomic structure and adaptation in the zoonotic malaria parasite Plasmodium knowlesi.
Assefa S; Lim C; Preston MD; Duffy CW; Nair MB; Adroub SA; Kadir KA; Goldberg JM; Neafsey DE; Divis P
2015
Proceedings of the National Academy of Sciences of the United States of America
See more Publications