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Dr Jackie Cliff

BA MSc PhD

Associate Professor

Room
Room 237

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

After obtaining my BA degree in Physiological Sciences from St Anne's College, University of Oxford, I completed the MSc in Immunology of Infectious Diseases at LSHTM. I studied for my PhD with Gerry Klaus at the National Institute for Medical Research, investigating the autocrine regulation of murine B cells. I joined LSHTM as a post-doctoral research fellow with Prof. Hazel Dockrell in 1999, investigating immune responses in tuberculosis.

Affiliations

Department of Infection Biology
Faculty of Infectious and Tropical Diseases

Centres

TB Centre

Teaching

I am the Programme Content Director for the Distance-Learning Masters Certificate/Diploma/MSc in Infectious Diseases. I also teach on the London-based Immunology of Infectious Diseases MSc course.

Research

I am interested in biomarkers of tuberculosis treatment-response, which would facilitate clinical trials of new TB therapies. We are characterising changes in human blood gene expression patterns which correlate with successful cure or with treatment-failure /relapse. We are also investigating how these are affected by co-morbidities, such as HIV/TB or helminth/TB co-infection. Candidate host gene expression panels from microarray and/or RNASeq transcriptomic datasets are being developed into more field-friendly tools for validation as potential biomarkers of TB treatment outcome.

As part of the TANDEM research consortium, we have been investigating the causal mechanism underlying the enhanced susceptibility to TB disease development caused by type 2 diabetes, by analysing gene expression profiles in TB/diabetes co-morbid patients compared to uncomplicated TB patients. We are interested in how such changes in gene expression affect the ability of macrophages to control M. tuberculosis. 

I also collaborate with the CURE-ME group to investigate disease pathogenesis in Myalgic Encephalomyelitis / Chronic Fatigue Syndrome. We have found altered cytotoxic cell phenotype, indicating ongoing anti-viral responses. We are currently expanding our research to include people with "Long COVID" to determine if the underlying mechanisms are similar in a subgroup of patients.

Research Area
Diagnostics
Drug discovery and development
T-cell immunology
Vaccines
Discipline
Genomics
Immunology
Molecular biology
Disease and Health Conditions
Infectious disease
Tuberculosis
Chronic Fatigue Syndrome
Country
Indonesia
Pakistan
Peru
Romania
Tanzania
South Africa
Region
East Asia & Pacific (all income levels)
Europe & Central Asia (all income levels)
European Union
Latin America & Caribbean (developing only)
South Asia
Sub-Saharan Africa (all income levels)

Selected Publications

Salivary DNA loads for human herpes viruses 6 and 7 are correlated with disease phenotype in Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome.
Lee J-S; Lacerda EM; Nacul L; Kingdon CC; Norris J; O'Boyle S; Roberts CH; Palla L; Riley EM; Cliff JM
2021
Impact of Intermediate Hyperglycemia and Diabetes on Immune Dysfunction in Tuberculosis.
Eckold C; Kumar V; Weiner J; Alisjahbana B; Riza A-L; Ronacher K; Coronel J; Kerry-Barnard S; Malherbe ST; Kleynhans L
2020
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Blood transcriptomics to characterize key biological pathways and identify biomarkers for predicting mortality in melioidosis.
Yimthin T; Cliff JM; Phunpang R; Ekchariyawat P; Kaewarpai T; Lee J-S; Eckold C; Andrada M; Thiansukhon E; Tanwisaid K
2020
Emerging microbes & infections
Cellular Immune Function in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).
Cliff JM; King EC; Lee J-S; Sepúlveda N; Wolf A-S; Kingdon C; Bowman E; Dockrell HM; Nacul L; Lacerda E
2019
Frontiers in Immunology
Gene expression profiles classifying clinical stages of tuberculosis and monitoring treatment responses in Ethiopian HIV-negative and HIV-positive cohorts.
Gebremicael G; Kassa D; Alemayehu Y; Gebreegziaxier A; Kassahun Y; van Baarle D; H M Ottenhoff T; M Cliff J; C Haks M
2019
PloS one
Metformin Alters Human Host Responses to Mycobacterium tuberculosis in Healthy Subjects.
Lachmandas E; Eckold C; Böhme J; Koeken VACM; Marzuki MB; Blok B; Arts RJW; Chen J; Teng KWW; Ratter J
2019
The Journal of infectious diseases
Host Gene Expression Kinetics During Treatment of Tuberculosis in HIV-Coinfected Individuals Is Independent of Highly Active Antiretroviral Therapy.
Gebremicael G; Kassa D; Quinten E; Alemayehu Y; Gebreegziaxier A; Belay Y; van Baarle D; Ottenhoff THM; Cliff JM; Haks MC
2018
The Journal of infectious diseases
Primary macrophages and J774 cells respond differently to infection with Mycobacterium tuberculosis.
Andreu N; Phelan J; de Sessions PF; Cliff JM; Clark TG; Hibberd ML
2017
Scientific reports
Excessive Cytolytic Responses Predict Tuberculosis Relapse After Apparently Successful Treatment.
Cliff JM; Cho J-E; Lee J-S; Ronacher K; King EC; van Helden P; Walzl G; Dockrell HM
2015
The Journal of infectious diseases
The human immune response to tuberculosis and its treatment: a view from the blood.
Cliff JM; Kaufmann SHE; McShane H; van Helden P; O'Garra A
2015
Immunological reviews
Distinct phases of blood gene expression pattern through tuberculosis treatment reflect modulation of the humoral immune response.
Cliff JM; Lee J-S; Constantinou N; Cho J-E; Clark TG; Ronacher K; King EC; Lukey PT; Duncan K; Van Helden PD
2012
The Journal of infectious diseases
Gene-expression patterns in whole blood identify subjects at risk for recurrent tuberculosis.
Mistry R; Cliff JM; Clayton CL; Beyers N; Mohamed YS; Wilson PA; Dockrell HM; Wallace DM; van Helden PD; Duncan K
2007
The Journal of infectious diseases
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