Prof Tim Clayton

Professor in Applied Medical Statistics

London School of Hygiene & Tropical Medicine
Keppel Street
United Kingdom

+44 (0)20 7927 2640
I have has worked at LSHTM in 1994 following my MSc in Medical Statistics. I have been based in the Department for Medical Statistics during this time except for a year in the Department of Infectious Disease Epidemiology. I am also a member of the LSHTM Clinical Trials Unit Management Board.


Department of Medical Statistics
Faculty of Epidemiology and Population Health


Centre for Data and Statistical Science for Health


I have taught at LSHTM throughout my time at LSHTM organising and teaching on numerous course including the Clinical Trials module (for over 20 years). I currently co-organise the Advanced Statistical Methods in Epidemiology with Richard Hayes and Kate Walker and have organised this module with Richard for over 25 years. I also teach on numerous short courses and involved in various teaching committees at LSHTM.


I have worked on clinical trials continuously since I started at LSHTM. I have been the statistician and co-investigator on numerous clinical trials, primarily in cardiovascular disease, over this period. I am currently the LSHTM principal investigator helping to lead a wonderful team running trials in trials in routine cerebral embolic protection in transcatheter aortic valve implantation (BHF PROTECT-TAVI), percutaneous coronary intervention in patients with ischaemic ventricular dysfunction (REVIVED-BCIS2), immediate coronary angiography after out of hospital cardiac arrest (ARREST) and high-risk coronary Intervention with percutaneous left ventricular unloading (CHIP-BCIS3). I am also a member of a the Women in Cardiovascular Trials Group, a collaboration to highlight the under-representation of women at all levels of cardiovascular trials with the aim to improve cardiovascular healthcare and research for women.
Research Area
Clinical trials
Randomised controlled trials
Disease and Health Conditions
Cardiovascular diseases
Non-communicable diseases
Kidney disease
United Kingdom
Euro area
Sub-Saharan Africa (all income levels)

Selected Publications

Safetxt: a safer sex intervention delivered by mobile phone messaging on sexually transmitted infections (STI) among young people in the UK - protocol for a randomised controlled trial.
FREE, C; MCCARTHY, OL; PALMER, MJ; Knight, R; EDWARDS, P; FRENCH, R; Baraitser, P; HICKSON, FC I; WELLINGS, K; ROBERTS, I; Bailey, JV; Hart, G; Michie, S; CLAYTON, T; Ploubidis, GB; CARPENTER, JR; Turner, KM E; DEVRIES, K; Potter, K;
Irbesartan in Marfan syndrome (AIMS): a double-blind, placebo-controlled randomised trial.
Mullen, M; Jin, XY; Child, A; Stuart, AG; DODD, M; Aragon-Martin, JA; Gaze, D; Kiotsekoglou, A; Yuan, L; Hu, J; Foley, C; VAN DYCK, L; KNIGHT, R; CLAYTON, T; Swan, L; Thomson, JD R; Erdem, G; Crossman, D; Flather, M; AIMS Investigators,;
The Lancet
Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised controlled trial.
Hausenloy, DJ; Kharbanda, RK; Møller, UK; Ramlall, M; Aarøe, J; Butler, R; Bulluck, H; CLAYTON, T; Dana, A; DODD, M; Engstrom, T; EVANS, R; Lassen, JF; Christensen, EF; Garcia-Ruiz, JM; Gorog, DA; Hjort, J; Houghton, RF; Ibanez, B; Knight, R; Lippert, FK; Lønborg, JT; Maeng, M; Milasinovic, D; More, R; ... CONDI-2/ERIC-PPCI Investigators,
Early remote ischaemic preconditioning leads to sustained improvement in allograft function after live donor kidney transplantation: long-term outcomes in the REnal Protection Against Ischaemia-Reperfusion in transplantation (REPAIR) randomised trial.
Veighey, KV; NICHOLAS, JM; CLAYTON, T; Knight, R; ROBERTSON, S; Dalton, N; Harber, M; Watson, CJ E; De Fijter, JW; Loukogeorgakis, S; MacAllister, R;
British Journal of Anaesthesia
Derivation and Validation of a Chronic Total Coronary Occlusion Intervention Procedural Success Score From the 20,000-Patient EuroCTO Registry: The EuroCTO (CASTLE) Score.
Szijgyarto, Z; Rampat, R; Werner, GS; Ho, C; Reifart, N; Lefevre, T; Louvard, Y; Avran, A; Kambis, M; Buettner, H-J; Di Mario, C; Gershlick, A; Escaned, J; Sianos, G; Galassi, A; Garbo, R; Goktekin, O; Meyer-Gessner, M; Lauer, B; Elhadad, S; Bufe, A; Boudou, N; Sievert, H; Martin-Yuste, V; Thuesen, L; ... Hildick-Smith, D.
JACC: Cardiovascular Interventions
Rationale and design of: A Randomized tRial of Expedited transfer to a cardiac arrest center for non-ST elevation out-of-hospital cardiac arrest: The ARREST randomized controlled trial.
Patterson, T; PERKINS, A; Perkins, GD; CLAYTON, T; EVANS, R; Nguyen, H; Wilson, K; Whitbread, M; Hughes, J; Fothergill, RT; Nevett, J; MOSWEU, I; McCrone, P; Dalby, M; Rakhit, R; MacCarthy, P; Perera, D; Nolan, JP; Redwood, SR;
American heart journal
Percutaneous Revascularization for Ischemic Ventricular Dysfunction: Rationale and Design of the REVIVED-BCIS2 Trial: Percutaneous Coronary Intervention for Ischemic Cardiomyopathy.
Perera, D; CLAYTON, T; Petrie, MC; Greenwood, JP; O'Kane, PD; EVANS, R; Sculpher, M; Mcdonagh, T; Gershlick, A; De Belder, M; Redwood, S; Carr-White, G; Marber, M; REVIVED investigators,;
Percutaneous Coronary Intervention for Ischemic Cardiomyopathy
Neutrophil gelatinase-associated lipocalin prior to cardiac surgery predicts acute kidney injury and mortality.
Bulluck, H; Maiti, R; Chakraborty, B; Candilio, L; CLAYTON, T; EVANS, R; Jenkins, DP; Kolvekar, S; Kunst, G; Laing, C; NICHOLAS, J; Pepper, J; Yellon, DM; Hausenloy, DJ;
Heart (British Cardiac Society)
Impact of call-to-balloon time on 30-day mortality in contemporary practice.
Varcoe, RW; CLAYTON, TC; Gray, HH; De Belder, MA; Ludman, PF; Henderson, RA; British Cardiovascular Intervention Society (BCIS),;
Heart (British Cardiac Society)
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