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Sian Clarke

BSc MSc PhD

Associate Professor
in Malaria Research and Control

Room
442

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
+ 44 7612 7833

BSc Biology, University of Sussex, UK; MSc Epidemiology, LSHTM, UK; PhD Malaria Epidemiology, University of Copenhagen, Denmark.

I have been based at LSHTM since 2002, when I came back to London to join the staff of the Gates Malaria Partnership. I am a founder member of the ACT Consortium, an international multidisciplinary research collaboration which conducts research on the deployment of ACTs for malaria treatment. I was awarded a Wellcome Trust Career Development Fellowship in 2009 to investigate the epidemiology and control of malaria in school-aged children, and was based overseas in Senegal for 3 years between 2010-2014.

I have previously worked with the DBL Centre for Health Research and Development, Copenhagen, Denmark, 1995-2002; and the Communicable Disease Surveillance Centre, Health Protection Agency, London, UK, 1988-1995. 

I am a member of the London International Development Centre.

Affiliations

Department of Disease Control
Faculty of Infectious and Tropical Diseases

Centres

Centre for Evaluation
Malaria Centre
Maternal, Adolescent, Reproductive & Child Health (MARCH)
Antimicrobial Resistance Centre

Teaching

I am the LSHTM Course Director of the MSc One Health, a joint course run by the Royal Veterinary College and LSHTM

I am academic co-ordinator of the MSc module on the "Epidemiology and Control of Malaria"

I also teach on the following courses:

  • MSc Public Health in Developing Countries
  • MSc Control of Infectious Diseases
  • MSc Epidemiology (distance learning)
  • MSc Infectious Diseases (distance learning)

Research

The primary aim of my research is the development and evaluation of disease control strategies to improve health in low-income countries, with a specific focus on malaria.

My current research investigates the (i) impact of asymptomatic malaria infections on anaemia and cognition; (ii) epidemiology and control of malaria in school-aged children; and (iii) interventions to improve treatment of malaria and other common childhood infections by community health workers, private clinics and drug shops.

Past research has also examined the spatial epidemiology of malaria in areas of seasonal transmission in West Africa, and low and unstable transmission in the East African Highlands.

I have led numerous intervention studies in sub-Saharan Africa, including randomised trials to evaluate the impact of intermittent parasite clearance in schools; seasonal malaria chemoprevention and nutritional interventions in pre-school children; malaria prevention during pregnancy (IPTp and ITNs); use of malaria rapid diagnostic tests by CHWs and drug shop vendors; and integrated community case management (iCCM).

I have worked in The Gambia, Kenya, Mali, Senegal and Uganda.

Research Area
Child health
Complex interventions
Diagnostics
Health systems
Maternal health
Micronutrients
Public health
Adolescent health
Health workers
Behaviour change
Chemotherapy
Disease control
Evaluation
Global Health
Impact evaluation
Mixed methods
Implementation research
Private sector
Randomised controlled trials
Schools
Discipline
Epidemiology
Operational research
Disease and Health Conditions
Infectious disease
Malaria
Malnutrition
Vector borne disease
Country
Gambia, The
Kenya
Mali
Nigeria
Senegal
Tanzania
Uganda
Region
Sub-Saharan Africa (all income levels)

Selected Publications

Introducing malaria rapid diagnostic tests in private medicine retail outlets: A systematic literature review.
Visser, T. ; Bruxvoort, K. ; Maloney, K. ; Leslie, T. ; Barat, L.M. ; Allan, R. ; Ansah, E.K. ; Anyanti, J. ; Boulton, I. ; Clarke, S.E. ; Cohen, J.L. ; Cohen, J.M. ; Cutherell, A. ; Dolkart, C. ; Eves, K. ; Fink, G. ; Goodman, C. ; Hutchinson, E. ; Lal, S. ; Mbonye, A. ; Onwujekwe, O. ; Petty, N. ; Pontarollo, J. ; Poyer, S. ; Schellenberg, D. ; Streat, E. ; Ward, A. ; Wiseman, V. ; Whitty, C.J. ; Yeung, S. ; Cunningham, J. ; Chandler, C.I. ;
PLoS One
Impact of introduction of rapid diagnostic tests for malaria on antibiotic prescribing: analysis of observational and randomised studies in public and private healthcare settings.
Hopkins, H. ; Bruxvoort, K.J. ; Cairns, M.E. ; Chandler, C.I. ; Leurent, B. ; Ansah, E.K. ; Baiden, F. ; Baltzell, K.A. ; Björkman, A. ; Burchett, H.E. ; Clarke, S.E. ; DiLiberto, D.D. ; Elfving, K. ; Goodman, C. ; Hansen, K.S. ; Kachur, S.P. ; Lal, S. ; Lalloo, D.G. ; Leslie, T. ; Magnussen, P. ; Jefferies, L.M. ; Mårtensson, A. ; Mayan, I. ; Mbonye, A.K. ; Msellem, M.I. ; Onwujekwe, O.E. ; Owusu-Agyei, S. ; Reyburn, H. ; Rowland, M.W. ; Shakely, D. ; Vestergaard, L.S. ; Webster, J. ; Wiseman, V.L. ; Yeung, S. ; Schellenberg, D. ; Staedke, S.G. ; Whitty, C.J. ;
BMJ
'Asymptomatic' Malaria: A Chronic and Debilitating Infection That Should Be Treated.
Chen, I.; Clarke, S.E.; Gosling, R.; Hamainza, B.; Killeen, G.; Magill, A.; O'Meara, W.; Price, R.N.; Riley, E.M.;
PLoS Med
'It puts life in us and we feel big': shifts in the local health care system during the introduction of rapid diagnostic tests for malaria into drug shops in Uganda.
Hutchinson, E. ; Chandler, C. ; Clarke, S. ; Lal, S. ; Magnussen, P. ; Kayendeke, M. ; Nabirye, C. ; Kizito, J. ; Mbonye, A. ;
Crit Public Health
A Cluster Randomised Trial Introducing Rapid Diagnostic Tests into Registered Drug Shops in Uganda: Impact on Appropriate Treatment of Malaria.
Mbonye, A.K. ; Magnussen, P. ; Lal, S. ; Hansen, K.S. ; Cundill, B. ; Chandler, C. ; Clarke, S.E. ;
PLoS One
Effect of intermittent preventive treatment of malaria on health and education in schoolchildren: a cluster-randomised, double-blind, placebo-controlled trial.
Clarke, S.E.; Jukes, M.C.; Njagi, J.K.; Khasakhala, L.; Cundill, B.; Otido, J.; Crudder, C.; Estambale, B.B.; Brooker, S.;
Lancet
See all Sian Clarke's Publications