Sian Clarke


Associate Professor
in Malaria Research and Control


Keppel Street
United Kingdom

+ 44 7612 7833

BSc Biology, University of Sussex, UK; MSc Epidemiology, LSHTM, UK; PhD Malaria Epidemiology, University of Copenhagen, Denmark.

I have been based at LSHTM since 2002, when joined the staff of the Gates Malaria Partnership. I am a founder member of the ACT Consortium, an international multidisciplinary research collaboration which conducts research on the deployment of ACTs for malaria treatment. I was awarded a Wellcome Trust Career Development Fellowship in 2009 to investigate the epidemiology and control of malaria in school-aged children, and was based overseas in Senegal for 3 years between 2010-2014.

I have previously worked with the DBL Centre for Health Research and Development, Copenhagen, Denmark, 1995-2002; and the Communicable Disease Surveillance Centre, Health Protection Agency, London, UK, 1988-1995. 

I am Co-Director of the LSHTM Malaria Centre, a multidisciplinary and cross-faculty network of researchers working on malaria. I am also a member of the London International Development Centre.


Department of Disease Control
Faculty of Infectious and Tropical Diseases


Centre for Evaluation
Malaria Centre
Maternal, Adolescent, Reproductive & Child Health (MARCH)
Antimicrobial Resistance Centre


I am the LSHTM Course Director of the MSc One Health, a joint course run by the Royal Veterinary College and LSHTM

I have previously been the academic co-ordinator of the MSc module on the "Epidemiology and Control of Malaria" for several years 2005-2009, 2015-2018.

I also teach on the following courses:

  • MSc Public Health in Developing Countries
  • MSc Control of Infectious Diseases
  • MSc Epidemiology (distance learning)
  • MSc Infectious Diseases (distance learning)


My research interest is in infectious disease epidemiology, public health and development in low-income countries. The primary aim of my research is the development and evaluation of disease control strategies to improve health in resource-constrained environments, with a specific focus on malaria.

My current research is focussed on: (i) the impact of asymptomatic malaria infections on anaemia, cognition and education; (ii) epidemiology and control of malaria in school-aged children; and (iii) interventions to improve the treatment of malaria and other common childhood infections by community health workers, private clinics and drug shops.

Past research has also examined the spatial epidemiology of malaria in areas of seasonal transmission in West Africa, and low and unstable transmission in the East African Highlands.

I have led numerous intervention studies in sub-Saharan Africa, including randomised trials to evaluate the impact of intermittent parasite clearance in schools; seasonal malaria chemoprevention and nutritional interventions in pre-school children; malaria prevention during pregnancy (IPTp and ITNs); use of malaria rapid diagnostic tests by CHWs and drug shop vendors; and integrated community case management (iCCM).

I have worked in The Gambia, Kenya, Mali, Senegal and Uganda.

Research Area
Child health
Complex interventions
Health systems
Maternal health
Public health
Adolescent health
Health workers
Behaviour change
Disease control
Global Health
Impact evaluation
Mixed methods
Implementation research
Private sector
Randomised controlled trials
Operational research
Disease and Health Conditions
Infectious disease
Vector borne disease
Gambia, The
Sub-Saharan Africa (all income levels)

Selected Publications

Impact of introduction of rapid diagnostic tests for malaria on antibiotic prescribing: analysis of observational and randomised studies in public and private healthcare settings.
Hopkins, H. ; Bruxvoort, K.J. ; Cairns, M.E. ; Chandler, C.I. ; Leurent, B. ; Ansah, E.K. ; Baiden, F. ; Baltzell, K.A. ; Björkman, A. ; Burchett, H.E. ; Clarke, S.E. ; DiLiberto, D.D. ; Elfving, K. ; Goodman, C. ; Hansen, K.S. ; Kachur, S.P. ; Lal, S. ; Lalloo, D.G. ; Leslie, T. ; Magnussen, P. ; Jefferies, L.M. ; Mårtensson, A. ; Mayan, I. ; Mbonye, A.K. ; Msellem, M.I. ; Onwujekwe, O.E. ; Owusu-Agyei, S. ; Reyburn, H. ; Rowland, M.W. ; Shakely, D. ; Vestergaard, L.S. ; Webster, J. ; Wiseman, V.L. ; Yeung, S. ; Schellenberg, D. ; Staedke, S.G. ; Whitty, C.J. ;
Impact of a malaria intervention package in schools on Plasmodium infection, anaemia and cognitive function in schoolchildren in Mali: a pragmatic cluster-randomised trial.
Clarke, S.E. ; Rouhani, S. ; Diarra, S. ; Saye, R. ; Bamadio, M. ; Jones, R. ; Traore, D. ; Traore, K. ; Jukes, M.C. ; Thuilliez, J. ; Brooker, S. ; Roschnik, N. ; Sacko, M. ;
BMJ Glob Health
Malaria in Middle Childhood and Adolescence
Brooker, S.J.; Clarke, S.; Fernando, D.; Gitonga, C.W.; Nankabirwa, J.; Schellenberg, D.; Greenwood, B.
Disease Control Priorities, Third Edition (Volume 8): Child and Adolescent Health and Development
'Asymptomatic' Malaria: A Chronic and Debilitating Infection That Should Be Treated.
Chen, I.; Clarke, S.E.; Gosling, R.; Hamainza, B.; Killeen, G.; Magill, A.; O'Meara, W.; Price, R.N.; Riley, E.M.;
PLoS Med
A Cluster Randomised Trial Introducing Rapid Diagnostic Tests into Registered Drug Shops in Uganda: Impact on Appropriate Treatment of Malaria.
Mbonye, A.K. ; Magnussen, P. ; Lal, S. ; Hansen, K.S. ; Cundill, B. ; Chandler, C. ; Clarke, S.E. ;
PLoS One
Effect of intermittent preventive treatment of malaria on health and education in schoolchildren: a cluster-randomised, double-blind, placebo-controlled trial.
Clarke, S.E.; Jukes, M.C.; Njagi, J.K.; Khasakhala, L.; Cundill, B.; Otido, J.; Crudder, C.; Estambale, B.B.; Brooker, S.;
See all Sian Clarke's Publications