Andrew Clark


Associate Professor


15-17 Tavistock Place
United Kingdom

I joined the staff of LSHTM in 2002. Most of my research involves evaluating the health and economic impact of different vaccines. This work is interdisciplinary (mathematical modelling, epidemiology, health economics, statistics, computer science and decision theory). I did my doctorate at LSHTM (modelling the potential benefits and risks of rotavirus vaccination in low-income and middle-income countries).


Faculty of Public Health and Policy
Department of Health Services Research and Policy


Centre for the Mathematical Modelling of Infectious Diseases (CMMID)
Vaccine Centre


I organise and teach Health Decision Science. This elective module is offered to students studying for Public Health by Distance Learning, and is the sister module to the intensive module of the same name, organised by Professor Mark Jit and Dr Kiesha Prem. I tutor students on the intensive MPH programme and am one of the Deputy Chairs of the DL exam board. Students (Masters, PhD and DrPH) are welcome to contact me if they are interested in topics related to the impact, safety, equity and economics of vaccination.



My research involves developing quantitative models to evaluate the health and economic impact of different vaccines (e.g. rotavirus, RSV, HPV) in low-income and middle-income countries. These range from simple proportionate outcomes models through to more complex individual-based transmission models. The models have been used by Ministries of Health in over 30 countries. They have also been used to inform WHO recommendations about vaccination schedules.

Research Area
Decision analysis
Economic evaluation
Capacity strengthening
Health economics
Mathematical modelling
Operational research
Disease and Health Conditions
Diarrhoeal diseases
Cervical cancer
Respiratory disease

Selected Publications

Routine childhood immunisation during the COVID-19 pandemic in Africa: a benefit-risk analysis of health benefits versus excess risk of SARS-CoV-2 infection.
Abbas K; Procter SR; van Zandvoort K; Clark A; Funk S; Mengistu T; Hogan D; Dansereau E; Jit M; Flasche S
The Lancet Global Health
Global, regional, and national estimates of the population at increased risk of severe COVID-19 due to underlying health conditions in 2020: a modelling study.
Clark A; Jit M; Warren-Gash C; Guthrie B; Wang HHX; Mercer SW; Sanderson C; McKee M; Troeger C; Ong KL
The Lancet. Global Health
Efficacy of live oral rotavirus vaccines by duration of follow-up: a meta-regression of randomised controlled trials.
Clark A; van Zandvoort K; Flasche S; Sanderson C; Bines J; Tate J; Parashar U; Jit M
Re-evaluating the potential impact and cost-effectiveness of rotavirus vaccination in 73 Gavi countries: a modelling study.
Debellut F; Clark A; Pecenka C; Tate J; Baral R; Sanderson C; Parashar U; Kallen L; Atherly D
The Lancet Global Health
Potential effect of age of BCG vaccination on global paediatric tuberculosis mortality: a modelling study.
Roy P; Vekemans J; Clark A; Sanderson C; Harris RC; White RG
The Lancet Global Health
Mortality reduction benefits and intussusception risks of rotavirus vaccination in 135 low-income and middle-income countries: a modelling analysis of current and alternative schedules.
Clark A; Tate J; Parashar U; Jit M; Hasso-Agopsowicz M; Henschke N; Lopman B; Van Zandvoort K; Pecenka C; Fine P
The Lancet Global Health
Removing the age restrictions for rotavirus vaccination: a benefit-risk modeling analysis.
Patel MM; Clark AD; Sanderson CFB; Tate J; Parashar UD
PLoS medicine
Global and regional risk of disabling sequelae from bacterial meningitis: a systematic review and meta-analysis.
Edmond K; Clark A; Korczak VS; Sanderson C; Griffiths UK; Rudan I
The Lancet infectious diseases
See more Publications