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Dr Antoine Claessens

PhD

Research Fellow

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
+220 44 95 443, ext 3016

Affiliations

Department of Pathogen Molecular Biology
Faculty of Infectious and Tropical Diseases

Centres

Malaria Centre

Research

I am a Research Fellow on a joint LSHTM/MRC-Gambia fellowship from the MRC. After my PhD at Edinburgh University with Pr Alex Rowe and a post-doc with Pr Dominic Kwiatkowski at the Sanger Institute, I joined LSHTM in 2014. I'm mainly based at the MRC-Gambia in Fajara, The Gambia, West Africa.

My current research focuses on genomics of Plasmodium falciparum asymptomatic infection.
The Plasmodium falciparum population in The Gambia fluctuates between a high prevalence in the wet season (transmission season) to a low prevalence in the dry season (no transmission). This drastic environmental change likely selects parasites that are genetically better suited for one environment or the other. We regularly collect blood samples from asymptomatic volunteers, sequence P. falciparum genomes and compare allele frequency variations between pre and post-transmission seasons. I am testing the hypothesis that some parasite allele frequencies will be associated with survival over the dry season.

Scientific interest keywords: Malaria, genomics, transcriptomics, antigenic variation, var genes, mutation rate, G-quadruplex.

Research Area
Parasites
Protozoa
Discipline
Genetic epidemiology
Genomics
Genetics
Molecular biology
Bioinformatics
Disease and Health Conditions
Malaria
Country
Gambia, The

Selected Publications

Culture adaptation of malaria parasites selects for convergent loss-of-function mutants.
Claessens, A. ; Affara, M. ; Assefa, S.A. ; Kwiatkowski, D.P. ; Conway, D.J. ;
2017
Sci Rep
Extreme mutation bias and high AT content in Plasmodium falciparum.
Hamilton, W.L. ; Claessens, A. ; Otto, T.D. ; Kekre, M. ; Fairhurst, R.M. ; Rayner, J.C. ; Kwiatkowski, D. ;
2016
Nucleic Acids Res
Generation of antigenic diversity in Plasmodium falciparum by structured rearrangement of Var genes during mitosis.
Claessens, A. ; Hamilton, W.L. ; Kekre, M. ; Otto, T.D. ; Faizullabhoy, A. ; Rayner, J.C. ; Kwiatkowski, D. ;
2014
PLoS Genet
See all Dr Antoine Claessens's Publications