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Dr Claire Calderwood

Clinical Research Fellow in Training

United Kingdom

I am Wellcome Trust Clinical PhD fellow in Global Health Research at LSHTM and respiratory physician in higher speciality training in the UK. For my PhD I am based in Zimbabwe with the THRU Zim team. My research is investigating chronic disease clustering within TB-affected households as a nested sub-study in ERASE-TB and seeks to develop an integrated health check for TB-affected households. More broadly, I am interested in approaches to address infectious and non-infectious chronic disease morbidity and mortality, particularly chronic respiratory disease including post-TB lung disease, in resource-limited settings.

Affiliations

Department of Clinical Research
Faculty of Infectious and Tropical Diseases

Research

TB is a disease of social, biological and economic vulnerability. The same conditions which put people at risk of TB increase the risk of chronic disease and multimorbidity, whilst presenting financial barriers to accessing healthcare. These underlying causes rarely affect an individual in isolation, they cluster in households and communities. Implementing screening for high-risk contacts of people with TB is a core component of the global ‘End TB’ strategy.

My research hypothesises that TB household contacts are a key risk group both for TB and chronic diseases, but that they have poor healthcare access; and that integrating chronic disease screening with that for TB is an effective way to address the large unmet burden of non-communicable disease morbidity and mortality in southern Africa.

Embedded in a large TB household contact screening study (ERASE-TB) my PhD research has three components. Firstly, I am exploring patterns of disease clustering in individuals and households affected by TB in three African countries (Zimbabwe, Tanzania and Mozambique). Secondly, I am exploring the social context of health screening through qualitative research with members of TB-affected households, healthcare workers and policy makers in Zimbabwe. These data will be used to, thirdly, develop and pilot an integrated health screening package for TB-affected households in Zimbabwe.

I also support the Vaxef study, evaluating the real-world effectiveness of COVID-19 vaccines among high-risk groups in Zimbabwe, and was part of the ICAROZ team, delivering occupational health checks for healthcare workers in Zimbabwe during the COVID-19 pandemic.
Research Area
Epidemiology
Implementation science
Disease and Health Conditions
Tuberculosis
Lung diseases
Non-communicable diseases
Country
Zimbabwe
Mozambique
Tanzania
Region
Sub-Saharan Africa (all income levels)

Selected Publications

Blood RNA biomarkers for tuberculosis screening in people living with HIV before antiretroviral therapy initiation: a diagnostic accuracy study.
Mann, T; Gupta, RK; Reeve, BW P; Ndlangalavu, G; Chandran, A; Krishna, AP; CALDERWOOD, CJ; Tshivhula, H; Palmer, Z; Naidoo, S; Mbu, DL; Theron, G; Noursadeghi, M;
2024
The Lancet. Global health
Beyond tuberculosis: a person-centred and rights-based approach to screening for household contacts.
CALDERWOOD, CJ; TIMIRE, C; Mavodza, C; Kavenga, F; Ngwenya, M; Madziva, K; Fielding, K; DIXON, J; FERRAND, RA; KRANZER, K;
2024
The Lancet. Global health
Prevalence of chronic conditions and multimorbidity among healthcare workers in Zimbabwe: Results from a screening intervention.
CALDERWOOD, CJ; Marambire, E; NZVERE, FP; Larsson, LS; Chingono, RM S; Kavenga, F; Redzo, N; Bandason, T; Rusakaniko, S; Mujuru, HA; SIMMS, V; KHAN, P; Gregson, CL; Ndhlovu, CE; FERRAND, RA; FIELDING, K; KRANZER, K;
2024
PLOS global public health
Evaluation of a comprehensive health check offered to frontline health workers in Zimbabwe.
Marambire, ET; Chingono, RM S; CALDERWOOD, CJ; Larsson, L; Sibanda, S; Kavenga, F; NZVERE, FP; Olaru, ID; SIMMS, V; McHugh, G; Bandason, T; Redzo, N; Gregson, CL; Maunganidze, AJ V; Pasi, C; Chiwanga, M; Chonzi, P; Ndhlovu, CE; Mujuru, H; Rusakaniko, S; FERRAND, RA; KRANZER, K;
2024
PLOS global public health
Higher loss of livelihood and impoverishment in households affected by tuberculosis compared to non-tuberculosis affected households in Zimbabwe: a cross-sectional study
TIMIRE, C; HOUBEN, RM G J; Pedrazzoli, D; FERRAND, RA; CALDERWOOD, C; BOND, V; Mbiba, F; KRANZER, K;
2023
medRxiv
Interdisciplinary perspectives on multimorbidity in Africa: developing an expanded conceptual model
DIXON, J; Morton, B; Nkhata, M; Silman, A; Simiyu, I; Spencer, S; Van Pinxteren, M; Bunn, C; CALDERWOOD, C; CHANDLER, CI R; Chikumbu, E; Crampin, A; Hurst, J; JOBE, M; Kengne, AP; Levitt, N; Moshabela, M; Owolabi, M; Peer, N; Phiri, N; Singh, S; Tamuhla, T; Tembo, M; Tiffin, N; Worrall, E; ... Limbani, F.
2023
medRxiv
Breaking from the Single Disease Model: Epidemiological and Health Systems Approaches to Multimorbidity
CALDERWOOD, C; DIXON, J;
2023
Clinical utility of WHO-recommended screening tools and development and validation of novel clinical prediction models for pulmonary tuberculosis screening among outpatients living with HIV: an individual participant data meta-analysis.
Dhana, A; Gupta, RK; Hamada, Y; Kengne, AP; Kerkhoff, AD; Yoon, C; Cattamanchi, A; Reeve, BW P; Theron, G; Ndlangalavu, G; Wood, R; Drain, PK; CALDERWOOD, CJ; Noursadeghi, M; Boyles, T; Meintjes, G; Maartens, G; Barr, DA;
2023
European respiratory review : an official journal of the European Respiratory Society
Blood RNA biomarkers for tuberculosis screening in people living with HIV prior to anti-retroviral therapy initiation: A diagnostic accuracy study.
Mann, T; Gupta, RK; Reeve, BW; Ndlangalavu, G; Chandran, A; Krishna, AP; CALDERWOOD, CJ; Tshivhula, H; Palmer, Z; Naidoo, S; Mbu, DL; Theron, G; Noursadeghi, M;
2023
medRxiv
Clinical utility of C-reactive protein-based triage for presumptive pulmonary tuberculosis in South African adults.
CALDERWOOD, CJ; Reeve, BW; Mann, T; Palmer, Z; Nyawo, G; Mishra, H; Ndlangalavu, G; Abubakar, I; Noursadeghi, M; Theron, G; Gupta, RK;
2022
The Journal of infection
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