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Dr Claire Calderwood

MSc DTM&H MRCP(UK)

Research Fellow

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

I am a Wellcome Trust Clinical PhD fellow in Global Health Research and StR in Respiratory and General Medicine (North East & Central Thames). I was previously an Academic Clinical Fellow at University College London.

I am currently based in Zimbabwe as part of the Zim-LSHTM research partnership between LSHTM and the Biomedical Research & Training Institute in Harare. My PhD research is embedded in the EDCTP-funded ERASE-TB study.

Affiliations

Faculty of Infectious and Tropical Diseases
Department of Clinical Research

Research

My research interests are tuberculosis and chronic diseases, particularly chronic respiratory disease including post-TB lung disease in resource-limited settings.

My PhD research hypothesises that TB household contacts are a key risk group both for TB and chronic diseases, but that they have poor healthcare access. Given the expanding burden of chronic disease morbidity and mortality in southern Africa, integrating chronic disease screening with that for TB may be an effective approach to address these dual threats.

Embedded in a large TB household contact screening study (ERASE-TB) the research has three components. Firstly, I am exploring patterns of disease clustering in individuals and households affected by TB in three African countries (Zimbabwe, Tanzania and Mozambique). Secondly, I am exploring the social context of health screening through qualitative research with members of TB-affected households, healthcare workers and policy makers in Zimbabwe. These data will be used to, thirdly, develop and pilot an integrated health screening package for TB-affected households in Zimbabwe.

I also support the ICAROZ project, led by Professor Katharina Kranzer, which is evaluating occupational health check-ups for frontline healthcare workers in Zimbabwe.

Research Area
Ageing
Clinical care
Complex interventions
Diagnostics
Infectious disease policy
Public health
Social and structural determinants of health
Adolescent health
Alcohol
Equity
Evaluation
Global Health
Mixed methods
Implementation research
Discipline
Epidemiology
Medicine
Operational research
Disease and Health Conditions
Cardiovascular disease
Chronic disease
Malnutrition
Mental health
Tuberculosis
Asthma
Diabetes
Respiratory disease
Country
Zimbabwe
Region
Sub-Saharan Africa (all income levels)

Selected Publications

Clinical utility of C-reactive protein-based triage for presumptive pulmonary tuberculosis in South African adults.
Calderwood CJ; Reeve BW; Mann T; Palmer Z; Nyawo G; Mishra H; Ndlangalavu G; Abubakar I; Noursadeghi M; Theron G
2022
The Journal of infection
Risk Factors for Hospitalization or Death Among Adults With Advanced HIV at Enrollment for Care in South Africa: A Secondary Analysis of the TB Fast Track Trial.
Calderwood CJ; Tlali M; Karat AS; Hoffmann CJ; Charalambous S; Johnson S; Grant AD; Fielding KL
2022
Open Forum Infectious Diseases
Dynamics of sputum conversion during effective tuberculosis treatment: A systematic review and meta-analysis.
Calderwood CJ; Wilson JP; Fielding KL; Harris RC; Karat AS; Mansukhani R; Falconer J; Bergstrom M; Johnson SM; McCreesh N
2021
PLoS medicine
Discovery and validation of a personalized risk predictor for incident tuberculosis in low transmission settings.
Gupta RK; Calderwood CJ; Yavlinsky A; Krutikov M; Quartagno M; Aichelburg MC; Altet N; Diel R; Dobler CC; Dominguez J
2020
Nature medicine
Severe chikungunya requiring intensive care in two travellers returning to the UK.
Calderwood C; Bhagani S; Cropley I; Papineni P
2019
Journal of travel medicine
The histone deacetylase inhibitor, romidepsin, as a potential treatment for pulmonary fibrosis.
Conforti F; Davies ER; Calderwood CJ; Thatcher TH; Jones MG; Smart DE; Mahajan S; Alzetani A; Havelock T; Maher TM
2017
Oncotarget
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