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Dr Matthew Cairns

BSc MSc PhD

Associate Professor
of Epidemiology and Sir Henry Dale Fellow

Room
G13

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
+44(0)207 958 8104

My research focuses on the epidemiology and control of malaria, with a particular focus on areas of seasonal malaria transmission. 

My current work aims to optimise the use of seasonal malaria chemoprevention (SMC) and seasonally-targeted vaccination for malaria, funded by a Wellcome Trust / Royal Society Sir Henry Dale Fellowship.

I previously held a Population Health Scientist Fellowship from the UK Medical Research Council (MRC).

I have been based in the MRC International Statistics and Epidemiology Group (ISEG) since 2010.  Prior to joining ISEG I completed an MSc and PhD in Epidemiology at LSHTM, both funded by the UK MRC. My first degree was in Biological Sciences.

Affiliations

Faculty of Epidemiology and Population Health
Department of Infectious Disease Epidemiology

Centres

Malaria Centre

Teaching

I teach mainly through the LSHTM Distance Learning programme, and am a co-organiser for the module Epidemiology of Infectious Diseases (EPM301). 

I also teach on a number of MSc modules in London (Statistical Methods in Epidemiology, Extended Epidemiology and related short-courses). 

I currently co-supervise two PhD students, Kammerle Schneider, who is investigating malaria in adolescents in Zambia, and Georgia Gore-Langton, who is working on the epidemiology of malaria coinfection with curable RTIs/STIs.

Research

My research to date has focused on the prevention of malaria in high risk groups (particularly young children and pregnant women), primarily through drug-based approaches.

An area of particular interest over the past 15 years has been seasonal malaria chemoprevention (SMC), previously called intermittent preventive treatment in children (IPTc). This is an approach to prevent malaria in children in areas where transmission is highly seasonal, recommended by WHO in 2012: http://www.who.int/malaria/areas/preventive_therapies/children/en/index.html, and now deployed at scale in large areas of the Sahel. 

I am particularly interested in how this intervention can be optimised, how it can be adapted to areas with different malaria epidemiology (including areas with less seasonal transmission), and how other interventions can be combined with SMC to maximise the impact on the malaria burden.

Ongoing work includes assessment of the new approach of seasonal vaccination against malaria, using the RTS,S/AS01 malaria vaccine, with or without SMC, in Burkina Faso and Mali clinicaltrials.gov: NCT03143218 and NCT04319380.

Research Area
Clinical trials
Drug resistance
Statistical methods
Vaccines
Chemotherapy
Disease control
Randomised controlled trials
Modelling
Discipline
Epidemiology
Statistics
Disease and Health Conditions
Infectious disease
Malaria
Country
Burkina Faso
Ghana
Guinea
The Gambia
Mali
Niger
Nigeria
Senegal
Chad
Region
Sub-Saharan Africa (developing only)

Selected Publications

Effect of Adding Azithromycin to Seasonal Malaria Chemoprevention.
Chandramohan D; Dicko A; Zongo I; Sagara I; Cairns M; Kuepfer I; Diarra M; Barry A; Tapily A; Nikiema F
2019
The New England journal of medicine
Effectiveness of Seasonal Malaria Chemoprevention in Children under Ten Years of Age in Senegal: A Stepped-Wedge Cluster-Randomised Trial.
Cissé B; Ba EH; Sokhna C; NDiaye JL; Gomis JF; Dial Y; Pitt C; NDiaye M; Cairns M; Faye E
2016
PLoS medicine
A Non-Inferiority, Individually Randomized Trial of Intermittent Screening and Treatment versus Intermittent Preventive Treatment in the Control of Malaria in Pregnancy.
Tagbor H; Cairns M; Bojang K; Coulibaly SO; Kayentao K; Williams J; Abubakar I; Akor F; Mohammed K; Bationo R
2015
PloS one
Estimating the potential public health impact of seasonal malaria chemoprevention in African children.
Cairns M; Roca-Feltrer A; Garske T; Wilson AL; Diallo D; Milligan PJ; Ghani AC; Greenwood BM
2012
Nature communications
See more Publications