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Professor Quentin Bickle

BA MSc PhD

Professor
of Parasitology

Room
Room 484

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
44 20 7927 2609

Fax.
44 20 7323 5687

After a degree in Zoology, I took the MSc in Medical Parasitology at LSHTM. My PhD project, on mechanisms of vaccine-induced immunity against schistosomes, was carried out at the LSHTM field station, Winches farm, during which time I also worked at the National Institute for Medical Research on schistosome antigens/antigen genes. After a year’s sabbatical at the Walter and Eliza Hall Institute in Melbourne working on malaria antigen genes I returned to work at the Keppel Street site of LSHTM, continuing studies on the immunology of helminths and of coinfections between helminths and protozoa or viruses. I have also been involved in field research on the immunology and control of intestinal worm infections. 

 

 

 



 

Affiliations

Immunology and Infection Department
Faculty of Infectious and Tropical Diseases

Research

The focus of my current research is on discovery of new anthelmintic drugs. This is based on novel techniques we developed at LSHTM e.g. use of an automated, whole-organism, High-throughput drug screen (HTS) using High Content imaging. This has allowed HT screening of very large compound collections provided by pharma and academia. Through collaboration with medicinal chemists the aim is to develop the lead compounds we have discovered into new clinical candidates for schistosomiasis and to extend use of the technology for screening against other helminth species.

 

 

Research Area
Drug discovery and development
Helminths
Parasites
Vaccines
Discipline
Immunopathology
Immunology
Molecular biology
Parasitology
Disease and Health Conditions
Schistosomiasis
Region
Latin America & Caribbean (all income levels)
Sub-Saharan Africa (all income levels)

Selected Publications

High Throughput Screening Identifies Novel Lead Compounds with Activity against Larval, Juvenile and Adult Schistosoma mansoni.
Mansour, N.R. ; Paveley, R. ; Gardner, J.M. ; Bell, A.S. ; Parkinson, T. ; Bickle, Q. ;
PLoS Negl Trop Dis
Application of RNAi to Genomic Drug Target Validation in Schistosomes.
Guidi, A. ; Mansour, N.R. ; Paveley, R.A. ; Carruthers, I.M. ; Besnard, J. ; Hopkins, A.L. ; Gilbert, I.H. ; Bickle, Q.D. ;
PLoS Negl Trop Dis
Whole organism high-content screening by label-free, image-based bayesian classification for parasitic diseases.
Paveley, R.A. ; Mansour, N.R. ; Hallyburton, I. ; Bleicher, L.S. ; Benn, A.E. ; Mikic, I. ; Guidi, A. ; Gilbert, I.H. ; Hopkins, A.L. ; Bickle, Q.D. ;
PLoS Negl Trop Dis
Early Exposure of Infants to GI Nematodes Induces Th2 Dominant Immune Responses Which Are Unaffected by Periodic Anthelminthic Treatment.
Wright, V.J.; Ame, S.M.; Haji, H.S.; Weir, R.E.; Goodman, D.; Pritchard, D.I.; Mohamed, M.R.; Haji, H.J.; Tielsch, J.M.; Stoltzfus, R.J.; Bickle, Q.D.;
PLoS Negl Trop Dis
Schistosomes: challenges in compound screening
Ramirez, B.; Bickle, Q.; Yousif, F.; Fakorede, F.K.; Mouries, M-A.; Nwaka, S.
Expert Opinion on Drug Discovery
The Schistosoma mansoni Hepatic Egg Granuloma Provides a Favorable Microenvironment for Sustained Growth of Leishmania donovani.
Hassan, M.F.; Zhang, Y.; Engwerda, C.R.; Kaye, P.M.; Sharp, H.; Bickle, Q.D.;
Am J Pathol
Reciprocal immunomodulation in a schistosome and hepatotropic virus coinfection model
Edwards, M. J.; Buchatska, E.; Ashton, M.; Montoya, M.; Bickle, Q. D.; Borrow, P.
Journal of Immunology
Laboratory and field evaluation of Schistosoma japonicum DNA vaccines in sheep and water buffalo in China
Shi, F. H.; Zhang, Y. B.; Ye, P.; Lin, J. J.; Cai, Y. M.; Shen, W.; Bickle, Q. D.; Taylor, M. G.
Vaccine
See all Professor Quentin Bickle's Publications