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Dr Tapan Bhattacharyya

PhD

Research Fellow
: serological diagnostics for protozoal diseases.

Room
Rm 390 (open plan), Rm 347 (lab)

LSHTM
Keppel Street
London
WC1E 7HT
United Kingdom

Tel.
0207 927 2319 (office)

Tapan joined LSHTM in 2009.

Molecular epidemiology of Trypanosoma cruzi, agent of Chagas disease. Chagas disease remains an important parasitic infection in the Americas. The vectors for the protozoan agent T. cruzi are triatomine bugs, which transmit the infective stage of the parasite in their faeces when taking a blood-meal. T. cruzi is classified into genetic lineages TcI-TcVI exhibiting a complex geographical distribution and a poorly understood relationship to clinical symptoms. My work is directed towards furthering understanding of the epidemiology of the different parasite lineages in this neglected tropical disease.

Serological diagnostics for Leishmania donovani, agent of visceral leishmaniasis. Visceral leishmaniasis, caused by infection with protozoa of the Leishmania donovani complex, remains a major public health problem in endemic regions of South Asia, East Africa, and Brazil. Phlebotomus and Lutzomyia sandflies are vectors in Eurasia/Africa and the Americas, respectively. My work is directed toward comparing and improving serological tests across endemicities, including identifying novel antigens.

PhD thesis: https://researchonline.lshtm.ac.uk/id/eprint/2173663/

Affiliations

Faculty of Infectious and Tropical Diseases
Department of Infection Biology

Teaching

Co-supervisor of current PhD students. Topics: Chagas disease; Strongyloidiasis; canine visceral leishmaniasis.

Supervision of Masters student research projects. Overseas components: Asia, Africa, South America.

Co-organiser: Introduction to Disease Agents and their Control (IDAC; module 3125)

Lecturer: Advanced Diagnostic Parsitology module.

 

 

Research

Recent publications:

Sanchez L, Messenger LA, Bhattacharyya T, Gilman RH, Mayta H, Colanzi R, Bozo R, Verástegui M, Miles MA, Bern C. Congenital Chagas disease in Santa Cruz Department, Bolivia, is dominated by Trypanosoma cruzi lineage V. Trans R Soc Trop Med Hyg. 2022 Jan 19;116(1):80-84. doi: 10.1093/trstmh/trab089. PMID: 34134129

Murphy N, Cardinal MV, Bhattacharyya T, Enriquez GF, Macchiaverna NP, Alvedro A, Freilij H, Martinez de Salazar P, Molina I, Mertens P, Gilleman Q, Gürtler RE, Miles MA. Assessing antibody decline after chemotherapy of early chronic Chagas disease patients. Parasit Vectors. 2021 Oct 20;14(1):543. doi: 10.1186/s13071-021-05040-6. PMID: 34670602.

Fujisawa K, Silcott-Niles C, Simonson P, Lamattina D, Humeres CA, Bhattacharyya T, Mertens P, Thunissen C, O'Rourke V, Pańczuk M, Whitworth JA, Salomón OD, Miles MA. Emergent canine visceral leishmaniasis in Argentina: Comparative diagnostics and relevance to proliferation of human disease. PLoS Negl Trop Dis. 2021 Jul 19;15(7):e0009552. doi: 10.1371/journal.pntd.0009552. PMID: 34280201; PMCID: PMC8289008..

Murphy N, Rooney B, Bhattacharyya T, Triana-Chavez O, Krueger A, Haslam SM, O'Rourke V, Pańczuk M, Tsang J, Bickford-Smith J, Gilman RH, Tetteh K, Drakeley C, Smales CM, Miles MA. Glycosylation of Trypanosoma cruzi TcI antigen reveals recognition by chagasic sera. Sci Rep. 2020 Oct 2;10(1):16395. doi: 10.1038/s41598-020-73390-9. PMID: 33009443; PMCID: PMC7532467.

Marlais T, Bhattacharyya T, Pearson C, Gardner BL, Marhoon S, Airs S, Hayes K, Falconar AK, Singh OP, Reed SG, El-Safi S, Sundar S, Miles MA. Isolation and characterisation of Leishmania donovani protein antigens from urine of visceral leishmaniasis patients. PLoS One. 2020 Sep 14;15(9):e0238840. doi: 10.1371/journal.pone.0238840. PMID: 32925980; PMCID: PMC7489519.

Franco CH, Warhurst DC, Bhattacharyya T, Au HYA, Le H, Giardini MA, Pascoalino BS, Torrecilhas AC, Romera LMD, Madeira RP, Schenkman S, Freitas- Junior LH, Chatelain E, Miles MA, Moraes CB. Novel structural CYP51 mutation in Trypanosoma cruzi associated with multidrug resistance to CYP51 inhibitors and reduced infectivity. Int J Parasitol Drugs Drug Resist. 2020 Aug;13:107-120. doi: 10.1016/j.ijpddr.2020.06.001. Epub 2020 Jun 13. PMID: 32688218; PMCID: PMC7369355.

Molina-Gonzalez SJ, Bhattacharyya T, AlShehri HR, Poulton K, Allen S, Miles MA, Arianitwe M, Tukahebwa EM, Webster B, Russell Stothard J, Bustinduy AL. Application of a recombinase polymerase amplification (RPA) assay and pilot field testing for Giardia duodenalis at Lake Albert, Uganda. Parasit Vectors. 2020 Jun 6;13(1):289. doi: 10.1186/s13071-020-04168-1. PMID: 32505215; PMCID: PMC7275508.

Franssen SU, Durrant C, Stark O, Moser B, Downing T, Imamura H, Dujardin JC, Sanders MJ, Mauricio I, Miles MA, Schnur LF, Jaffe CL, Nasereddin A, Schallig H, Yeo M, Bhattacharyya T, Alam MZ, Berriman M, Wirth T, Schönian G, Cotton JA. Global genome diversity of the Leishmania donovani complex. Elife. 2020 Mar 25;9:e51243. doi: 10.7554/eLife.51243. PMID: 32209228; PMCID: PMC7105377.

McClean MCW, Bhattacharyya T, Mertens P, Murphy N, Gilleman Q, Gustin Y, Zeippen N, Xavier SCC, Jansen AM, Miles MA. A lineage-specific rapid diagnostic test (Chagas Sero K-SeT) identifies Brazilian Trypanosoma cruzi II/V/VI reservoir hosts among diverse mammalian orders. PLoS One. 2020 Jan 17;15(1):e0227828. doi: 10.1371/journal.pone.0227828. Erratum in: PLoS One. 2020 Apr 2;15(4):e0231566. PMID: 31951634; PMCID: PMC6968848.

Bhattacharyya T, Murphy N, Miles MA. Trypanosoma cruzi lineage- specific serology: new rapid tests for resolving clinical and ecological associations. Future Sci OA. 2019 Oct 30;5(10):FSO422. doi: 10.2144/fsoa-2019-0103. PMID: 31827891; PMCID: PMC6900971.

Murphy N, Macchiaverna NP, Victoria Cardinal M, Bhattacharyya T, Mertens P, Zeippen N, Gustin Y, Gilleman Q, Gürtler RE, Miles MA. Lineage-specific rapid diagnostic tests can resolve Trypanosoma cruzi TcII/V/VI ecological and epidemiological associations in the Argentine Chaco. Parasit Vectors. 2019 Sep 16;12(1):424. doi: 10.1186/s13071-019-3681-7. PMID: 31522683; PMCID: PMC6746045.

Collis S, El-Safi S, Atia AA, Bhattacharyya T, Hammad A, Den Boer M, Le H, Whitworth JA, Miles MA. Epidemiological and molecular investigation of resurgent cutaneous leishmaniasis in Sudan. Int J Infect Dis. 2019 Nov;88:14-20. doi: 10.1016/j.ijid.2019.08.018. Epub 2019 Aug 20. PMID: 31442631; PMCID: PMC6838665.

Marlais T, Bhattacharyya T, Singh OP, Mertens P, Gilleman Q, Thunissen C, Hinckel BCB, Pearson C, Gardner BL, Airs S, de la Roche M, Hayes K, Hafezi H, Falconar AK, Eisa O, Saad A, Khanal B, Bhattarai NR, Rijal S, Boelaert M, El- Safi S, Sundar S, Miles MA. Visceral Leishmaniasis IgG1 Rapid Monitoring of Cure vs. Relapse, and Potential for Diagnosis of Post Kala-Azar Dermal Leishmaniasis. Front Cell Infect Microbiol. 2018 Dec 13;8:427. doi: 10.3389/fcimb.2018.00427. PMID: 30619774; PMCID: PMC6300496.

Mollett G, Bremer Hinckel BC, Bhattacharyya T, Marlais T, Singh OP, Mertens P, Falconar AK, El-Safi S, Sundar S, Miles MA. Detection of Immunoglobulin G1 Against rK39 Improves Monitoring of Treatment Outcomes in Visceral Leishmaniasis. Clin Infect Dis. 2019 Sep 13;69(7):1130-1135. doi: 10.1093/cid/ciy1062. PMID: 30541022; PMCID: PMC6743847.

Research Area
Diagnostics
Parasites
Trypanosomes
Protozoa
Discipline
Genetic epidemiology
Immunoepidemiology
Molecular epidemiology
Immunology
Microbiology
Molecular biology
Parasitology
Disease and Health Conditions
Leishmaniasis
Chagas Disease
Neglected Tropical Diseases (NTDs)
Tropical diseases
Region
World

Selected Publications

Refining wet lab experiments with in silico searches: A rational quest for diagnostic peptides in visceral leishmaniasis.
Bremer Hinckel BC; Marlais T; Airs S; Bhattacharyya T; Imamura H; Dujardin J-C; El-Safi S; Singh OP; Sundar S; Falconar AK
2019
PLoS neglected tropical diseases
Severity of Chagasic Cardiomyopathy Is Associated With Response to a Novel Rapid Diagnostic Test for Trypanosoma cruzi TcII/V/VI.
Bhattacharyya T; Messenger LA; Bern C; Mertens P; Gilleman Q; Zeippen N; Bremer Hinckel BC; Murphy N; Gilman RH; Miles MA
2018
Clinical infectious diseases
Visceral Leishmaniasis IgG1 Rapid Monitoring of Cure vs. Relapse, and Potential for Diagnosis of Post Kala-Azar Dermal Leishmaniasis.
Marlais T; Bhattacharyya T; Singh OP; Mertens P; Gilleman Q; Thunissen C; Hinckel BCB; Pearson C; Gardner BL; Airs S
2018
Frontiers in Cellular and Infection Microbiology
Detection of Immunoglobulin G1 Against rK39 Improves Monitoring of Treatment Outcomes in Visceral Leishmaniasis.
Mollett G; Bremer Hinckel BC; Bhattacharyya T; Marlais T; Singh OP; Mertens P; Falconar AK; El-Safi S; Sundar S; Miles MA
2018
Clinical Infectious Diseases
Diagnostic antigens for visceral leishmaniasis: clarification of nomenclatures.
Bhattacharyya T; Marlais T; Miles MA
2017
Parasites & vectors
IgG1 as a potential biomarker of post-chemotherapeutic relapse in visceral leishmaniasis, and adaptation to a rapid diagnostic test.
Bhattacharyya T; Ayandeh A; Falconar AK; Sundar S; El-Safi S; Gripenberg MA; Bowes DE; Thunissen C; Singh OP; Kumar R
2014
PLoS neglected tropical diseases
Significantly lower anti-Leishmania IgG responses in Sudanese versus Indian visceral leishmaniasis.
Bhattacharyya T; Bowes DE; El-Safi S; Sundar S; Falconar AK; Singh OP; Kumar R; Ahmed O; Boelaert M; Miles MA
2014
PLoS neglected tropical diseases
Development of peptide-based lineage-specific serology for chronic Chagas disease: geographical and clinical distribution of epitope recognition.
Bhattacharyya T; Falconar AK; Luquetti AO; Costales JA; Grijalva MJ; Lewis MD; Messenger LA; Tran TT; Ramirez J-D; Guhl F
2014
PLoS neglected tropical diseases
Multiple mitochondrial introgression events and heteroplasmy in trypanosoma cruzi revealed by maxicircle MLST and next generation sequencing.
Messenger LA; Llewellyn MS; Bhattacharyya T; Franzén O; Lewis MD; Ramírez JD; Carrasco HJ; Andersson B; Miles MA
2012
PLoS neglected tropical diseases
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