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Dr Helen Ayles

BSc MBBS MRCP DTM&H MSc PhD

Reader
Director of Research ZAMBART Project

Room
ZAMBART Project

ZAMBART House
Ridgeway Campus
Lusaka
United Kingdom

Tel.
+260 21 1257215/1254710

Fax.
+260 21 1254710

I am a Reader in the Clinical research Unit London School of Hygiene and Tropical Medicine and for the last 11 years have been director of research at Zambart, based full time in Lusaka Zambia.

I trained as a Physician in London and specialized in infectious and tropical diseases. I have worked as a clinician in UK, Uganda and Zambia and have over 20 years of developing country experience both in clinical TB/HIV management and epidemiology, leading Zambart that has conducted research into the dual TB/HIV epidemic for 20 years in Zambia.

I am the Zambia PI for the PopART (HPTN 071) Trial which will investigate whether a strategy of universal test and treat for HIV can reduce the incidence of HIV at community level. This important trial is being funded by a group of donors including OGAC, NIH and The Bill and Melinda Gates Foundation. I am also a PI for the BHOMA study, a community randomised trial to evaluate an intervention aimed at improving health outcomes by strengthening the health system. This study  is one of the 4 studies funded by the African health Initiative of the Doris Duke Charitable Foundation. I am also a site Pi on a new TB vaccine trial being conducted jointly by GSK and Aeras. Zambart is the research partner in Zambia on the STAR project ( HIV Self-Testing in Africa) funded by UNITAID which is looking to stimulate and shape the market for HIV self testing in 3 countries in Southern Africa. My PhD student ( Dr S-L Bailey) is currently conducting studies looking at the association of TB and diabetes, and I am also a co-supervisor fro Mragaret tembo who is looking at Hypertension in rural Zambia.

Other research grants and interests include: field evaluation of TB diagnostics, association of TB and NCD as well as operational research into the implementation of TB/HIV collaborative activities.

I am  a technical advisor on national TB/HIV and MDR-TB working groups and part of the Zambian national TB review team and a core group member of the WHO TB/HIV working group.

Affiliations

Faculty of Infectious and Tropical Diseases
Department of Clinical Research

Centres

Tuberculosis (TB) Centre

Teaching

I am  a tutor on the DL infectious Diseases tuberculosis module, and take part in face to face teaching in London when I am there as part of the DTM&H and AIDS module

I currently have 1 PhD student, sarah-Lou Bailey and am co-supervisor for Margaret Tembo.

Research

I am the Zambia PI for the PopART (HPTN 071) Trial which will investigate whether a strategy of universal test and treat for HIV can reduce the incidence of HIV at community level. This important trail is being funded by a group of donors including OGAC, NIH and The Bill and Melinda Gates Foundation. I am also a PI for the BHOMA study, a community randomised trial to evaluate an intervention aimed at improving health outcomes by strengthening the health system. This study  is one of the 4 studies funded by the African health Initiative of the Doris Duke Charitable Foundation.

I am a site PI for the GSK/Aeras TB-018 study a phase IIb trial of a novel TB vaccine.

I am also an investigator in the UNITAID funded HIV self testing in Africa (STAR) Project

I am Director of Research at ZAMBART Project in Zambia. ZAMBART is an independent research NGO but is closely affiliated to both LSHTM and the University of Zambia School of Medicine in Lusaka, which houses the project. ZAMBART employs more than 600 staff working on our studies. We have state of the art laboratories for TB and HIV in Lusaka

Research Area
Clinical trials
Complex interventions
Diagnostics
Health systems
Primary care
Public health
Vaccines
Adolescent health
Randomised controlled trials
Discipline
Epidemiology
Medicine
Operational research
Vaccinology
Disease and Health Conditions
HIV/AIDS
Infectious disease
Tuberculosis
Diabetes
Non-communicable diseases
Tropical diseases
Country
Zambia
Region
Sub-Saharan Africa (all income levels)

Selected Publications

Measuring health system strengthening: application of the balanced scorecard approach to rank the baseline performance of three rural districts in zambia.
Mutale, W. ; Godfrey-Fausset, P. ; Mwanamwenge, M.T. ; Kasese, N. ; Chintu, N. ; Balabanova, D. ; Spicer, N. ; Ayles, H. ;
PLoS One
Effect of household and community interventions on the burden of tuberculosis in southern Africa: the ZAMSTAR community-randomised trial.
Ayles, H.; Muyoyeta, M.; Du Toit, E.; Schaap, A.; Floyd, S.; Simwinga, M.; Shanaube, K.; Chishinga, N.; Bond, V.; Dunbar, R.; De Haas, P.; James, A.; van Pittius, N.C.; Claassens, M.; Fielding, K.; Fenty, J.; Sismanidis, C.; Hayes, R.J.; Beyers, N.; Godfrey-Faussett, P.; the ZAMSTAR team, .;
Lancet
Field comparison of OraQuick ADVANCE Rapid HIV-1/2 antibody test and two blood-based rapid HIV antibody tests in Zambia.
Zachary, D. ; Mwenge, L. ; Muyoyeta, M. ; Shanaube, K. ; Schaap, A. ; Bond, V. ; Kosloff, B. ; de Haas, P. ; Ayles, H. ;
BMC Infect Dis
Development of a Standardized Screening Rule for Tuberculosis in People Living with HIV in Resource-Constrained Settings: Individual Participant Data Meta-analysis of Observational Studies
Getahun, H.; Kittikraisak, W.; Heilig, C.M.; Corbett, E.L.; Ayles, H.; Cain, K.P.; Grant, A.D.; Churchyard, G.J.; Kimerling, M.; Shah, S.; Lawn, S.D.; Wood, R.; Maartens, G.; Granich, R.; Date, A.A.; Varma, J.K.
Plos Medicine
Risk Factors Associated with Positive QuantiFERON-TB Gold In-Tube and Tuberculin Skin Tests Results in Zambia and South Africa
Shanaube, K.; Hargreaves, J.; Fielding, K.; Schaap, A.; Lawrence, K.A.; Hensen, B.; Sismanidis, C.; Menezes, A.; Beyers, N.; Ayles, H.; Godfrey-Faussett, P.;
PLoS One
The Association between Household Socioeconomic Position and Prevalent Tuberculosis in Zambia: A Case-Control Study.
Boccia, D. ; Hargreaves, J. ; De Stavola, B.L. ; Fielding, K. ; Schaap, A. ; Godfrey-Faussett, P. ; Ayles, H. ;
PLoS One
Prevalence of Tuberculosis, HIV and Respiratory Symptoms in Two Zambian Communities: Implications for Tuberculosis Control in the Era of HIV.
Ayles, H.; Schaap, A.; Nota, A.; Sismanidis, C.; Tembwe, R.; De Haas, P.; Muyoyeta, M.; Beyers, N.; Godfrey-Faussett, P; for the ZAMSTAR Study Team, .;
PLoS One
Tuberculosis infection in zambia: the association with relative wealth.
Boccia, D.; Hargreaves, J.; Ayles, H.; Fielding, K.; Simwinga, M.; Godfrey-Faussett, P.;
Am J Trop Med Hyg
See all Dr Helen Ayles's Publications