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Dr Helen Ayles

BSc MBBS MRCP DTM&H MSc PhD

Professor
of Infectious Diseases and International Health, Director of Research ZAMBART Project

Room
ZAMBART Project

Zambart
Lusaka
Zambia

Tel.
+260 21 1257215/1254710

Fax.
+260 21 1254710

I am a professor in the Clinical research Unit London School of Hygiene and Tropical Medicine and for the last 14 years have been Director of Research at Zambart, based full time in Lusaka Zambia.

I trained as a Physician in London and specialized in infectious and tropical diseases. I have worked as a clinician in UK, Uganda and Zambia and have over 20 years of developing country experience both in clinical TB/HIV management and epidemiology, leading Zambart that has conducted research into the dual TB/HIV epidemic for 20 years in Zambia.

My key research interests are in the fields of TB/HIV and the overlap between them. I have led a number of large cluster-randomised trials of complex public health interventions.

Other research grants and interests include: field evaluation of TB diagnostics, adolescent health, association of TB and NCD as well as operational research into the implementation of TB/HIV collaborative activities.

Affiliations

Department of Clinical Research
Faculty of Infectious and Tropical Diseases

Centres

TB Centre

Teaching

I am  a tutor on the DL infectious Diseases tuberculosis module, and take part in face to face teaching in London when I am there as part of the DTM&H and AIDS module

I currently have 4 PhD students, Lily Telisinghe, Mohammed Limbada, Modupe Amofa-Sekyi and Mwelwa Phiri

Research

I am the overall PI for the TREATS consortium which will evaluate the impact fo the PopART intervention on TB, looking at the incidence of TB infection in adolescents and the prevalence of active TB disease in adults. We will also be investigating the role of new diagnostic tools in TB surveys.

I am the PI for the Yathu Yathu (By us, for us) trial which was developed by our adolescent community advisory board members in Lusaka. This study will investigate the uptake of adolescent SRH services at community one-stop shops using innovative technology.

I was the Zambia PI for the PopART (HPTN 071) Trial which  investigated whether demonstrated that a strategy of universal test and treat for HIV reduced the incidence of HIV at community level. We are finishing analyses fromt hsi trial and some sub-studies

I was a site PI for the GSK/Aeras TB-018 study a phase IIb trial of a novel TB vaccine which demonstrated a 50% vaccine efficacy.

I am also an investigator in the UNITAID funded HIV self testing in Africa (STAR) Project

I am Director of Research at Zambart in Zambia. Zambart is an independent research NGO but is closely affiliated to both LSHTM and the University of Zambia School of Public Health in Lusaka, which houses the project. Zambart employs more than 600 staff working on our studies. We have state of the art laboratories for TB and HIV in Lusaka

Research Area
Clinical trials
Complex interventions
Diagnostics
Health systems
Primary care
Public health
Vaccines
Adolescent health
Randomised controlled trials
Discipline
Epidemiology
Medicine
Operational research
Vaccinology
Disease and Health Conditions
HIV/AIDS
Infectious disease
Tuberculosis
Diabetes
Non-communicable diseases
Tropical diseases
Country
Zambia
Region
Sub-Saharan Africa (all income levels)

Selected Publications

Determination of HIV status and identification of incident HIV infections in a large, community-randomized trial: HPTN 071 (PopART).
Eshleman SH; Piwowar-Manning E; Wilson EA; Lennon D; Fogel JM; Agyei Y; Sullivan PA; Weng L; Moore A; Laeyendecker O
2020
Journal of the International AIDS Society
Smoking and HIV associated with subclinical tuberculosis: analysis of a population-based prevalence survey.
Gunasekera K; Cohen T; Gao W; Ayles H; Godfrey-Faussett P; Claassens M
2020
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
What do the Universal Test and Treat trials tell us about the path to HIV epidemic control?
Havlir D; Lockman S; Ayles H; Larmarange J; Chamie G; Gaolathe T; Iwuji C; Fidler S; Kamya M; Floyd S
2020
Journal of the International AIDS Society
Stigma and Judgment Toward People Living with HIV and Key Population Groups Among Three Cadres of Health Workers in South Africa and Zambia: Analysis of Data from the HPTN 071 (PopART) Trial.
Krishnaratne S; Bond V; Stangl A; Pliakas T; Mathema H; Lilleston P; Hoddinott G; Bock P; Ayles H; Fidler S
2020
AIDS patient care and STDs
Quantifying HIV transmission flow between high-prevalence hotspots and surrounding communities: a population-based study in Rakai, Uganda.
Ratmann O; Kagaayi J; Hall M; Golubchick T; Kigozi G; Xi X; Wymant C; Nakigozi G; Abeler-Dörner L; Bonsall D
2020
The Lancet. HIV
Genital Self-Sampling Compared with Cervicovaginal Lavage for the Diagnosis of Female Genital Schistosomiasis in Zambian Women: the BILHIV Study
Sturt A; Webb E; Phiri C; Mweene T; Chola N; van Dam G; Corstjens P; Wessels E; Stothard R; Hayes R
2020
PLoS Neglected Tropical Diseases
Development of parallel measures to assess HIV stigma and discrimination among people living with HIV, community members and health workers in the HPTN 071 (PopART) trial in Zambia and South Africa.
Stangl AL; Lilleston P; Mathema H; Pliakas T; Krishnaratne S; Sievwright K; Bell-Mandla N; Vermaak R; Mainga T; Steinhaus M
2019
Journal of the International AIDS Society
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