Dr Helen Ayles


of Infectious Diseases and International Health, Director of Research ZAMBART Project


Ridgeway Campus

+260 21 1257215/1254710

+260 21 1254710

I am a professor in the Clinical research Unit London School of Hygiene and Tropical Medicine and for the last 14 years have been Director of research at Zambart, based full time in Lusaka Zambia.

I trained as a Physician in London and specialized in infectious and tropical diseases. I have worked as a clinician in UK, Uganda and Zambia and have over 20 years of developing country experience both in clinical TB/HIV management and epidemiology, leading Zambart that has conducted research into the dual TB/HIV epidemic for 20 years in Zambia.

I am the Zambia PI for the PopART (HPTN 071) Trial which will investigate whether a strategy of universal test and treat for HIV can reduce the incidence of HIV at community level. This important trial is being funded by a group of donors including OGAC, NIH and The Bill and Melinda Gates Foundation.

I am also the PI of a consortium looking at the impact of combined TB/HIV interventions on TB at community level. This consortium called TREATS is funded by the EDCTP

Other research grants and interests include: field evaluation of TB diagnostics, adolescent health, association of TB and NCD as well as operational research into the implementation of TB/HIV collaborative activities.


Department of Clinical Research
Faculty of Infectious and Tropical Diseases


Tuberculosis (TB) Centre


I amĀ  a tutor on the DL infectious Diseases tuberculosis module, and take part in face to face teaching in London when I am there as part of the DTM&H and AIDS module

I currently have 2 PhD students, Lily Telisinghe and Mohammed Limbada


I am the Zambia PI for the PopART (HPTN 071) Trial which will investigate whether a strategy of universal test and treat for HIV can reduce the incidence of HIV at community level. This important trial is being funded by a group of donors including OGAC, NIH and The Bill and Melinda Gates Foundation.

I am the overall PI for the TREATS consortium which will evaluate the impact fo the PopART intervention on TB, looking at the incidence of TB infection in adolescents and the prevalence of active TB disease in adults. We will also be investigating the role of new diagnostic tools in TB surveys.

I am the PI for the Yathu Yathu (By us, for us) trial which was developed by our adolescent community advisory board members in Lusaka. This study will investigate the uptake of adolescent SRH services at community one-stop shops using innovative technology.

I am a site PI for the GSK/Aeras TB-018 study a phase IIb trial of a novel TB vaccine.

I am also an investigator in the UNITAID funded HIV self testing in Africa (STAR) Project

I am Director of Research at ZAMBART Project in Zambia. ZAMBART is an independent research NGO but is closely affiliated to both LSHTM and the University of Zambia School of Medicine in Lusaka, which houses the project. ZAMBART employs more than 600 staff working on our studies. We have state of the art laboratories for TB and HIV in Lusaka

Research Area
Clinical trials
Complex interventions
Health systems
Primary care
Public health
Adolescent health
Randomised controlled trials
Operational research
Disease and Health Conditions
Infectious disease
Non-communicable diseases
Tropical diseases
Sub-Saharan Africa (all income levels)

Selected Publications

Measuring health system strengthening: application of the balanced scorecard approach to rank the baseline performance of three rural districts in zambia.
Mutale, W. ; Godfrey-Fausset, P. ; Mwanamwenge, M.T. ; Kasese, N. ; Chintu, N. ; Balabanova, D. ; Spicer, N. ; Ayles, H. ;
PLoS One
Effect of household and community interventions on the burden of tuberculosis in southern Africa: the ZAMSTAR community-randomised trial.
Ayles, H.; Muyoyeta, M.; Du Toit, E.; Schaap, A.; Floyd, S.; Simwinga, M.; Shanaube, K.; Chishinga, N.; Bond, V.; Dunbar, R.; De Haas, P.; James, A.; van Pittius, N.C.; Claassens, M.; Fielding, K.; Fenty, J.; Sismanidis, C.; Hayes, R.J.; Beyers, N.; Godfrey-Faussett, P.; the ZAMSTAR team, .;
Field comparison of OraQuick ADVANCE Rapid HIV-1/2 antibody test and two blood-based rapid HIV antibody tests in Zambia.
Zachary, D. ; Mwenge, L. ; Muyoyeta, M. ; Shanaube, K. ; Schaap, A. ; Bond, V. ; Kosloff, B. ; de Haas, P. ; Ayles, H. ;
BMC Infect Dis
Development of a Standardized Screening Rule for Tuberculosis in People Living with HIV in Resource-Constrained Settings: Individual Participant Data Meta-analysis of Observational Studies
Getahun, H.; Kittikraisak, W.; Heilig, C.M.; Corbett, E.L.; Ayles, H.; Cain, K.P.; Grant, A.D.; Churchyard, G.J.; Kimerling, M.; Shah, S.; Lawn, S.D.; Wood, R.; Maartens, G.; Granich, R.; Date, A.A.; Varma, J.K.
Plos Medicine
Risk Factors Associated with Positive QuantiFERON-TB Gold In-Tube and Tuberculin Skin Tests Results in Zambia and South Africa
Shanaube, K.; Hargreaves, J.; Fielding, K.; Schaap, A.; Lawrence, K.A.; Hensen, B.; Sismanidis, C.; Menezes, A.; Beyers, N.; Ayles, H.; Godfrey-Faussett, P.;
PLoS One
The Association between Household Socioeconomic Position and Prevalent Tuberculosis in Zambia: A Case-Control Study.
Boccia, D. ; Hargreaves, J. ; De Stavola, B.L. ; Fielding, K. ; Schaap, A. ; Godfrey-Faussett, P. ; Ayles, H. ;
PLoS One
Prevalence of Tuberculosis, HIV and Respiratory Symptoms in Two Zambian Communities: Implications for Tuberculosis Control in the Era of HIV.
Ayles, H.; Schaap, A.; Nota, A.; Sismanidis, C.; Tembwe, R.; De Haas, P.; Muyoyeta, M.; Beyers, N.; Godfrey-Faussett, P; for the ZAMSTAR Study Team, .;
PLoS One
Tuberculosis infection in zambia: the association with relative wealth.
Boccia, D.; Hargreaves, J.; Ayles, H.; Fielding, K.; Simwinga, M.; Godfrey-Faussett, P.;
Am J Trop Med Hyg
See all Dr Helen Ayles's Publications