Dr Helen Ayles


of Infectious Diseases and International Health, Director of Research ZAMBART Project



+260 21 1257215/1254710

+260 21 1254710

I am a professor in the Clinical research Unit London School of Hygiene and Tropical Medicine and for the last 14 years have been Director of Research at Zambart, based full time in Lusaka Zambia.

I trained as a Physician in London and specialized in infectious and tropical diseases. I have worked as a clinician in UK, Uganda and Zambia and have over 20 years of developing country experience both in clinical TB/HIV management and epidemiology, leading Zambart that has conducted research into the dual TB/HIV epidemic for 20 years in Zambia.

My key research interests are in the fields of TB/HIV and the overlap between them. I have led a number of large cluster-randomised trials of complex public health interventions.

Other research grants and interests include: field evaluation of TB diagnostics, adolescent health, association of TB and NCD as well as operational research into the implementation of TB/HIV collaborative activities.


Faculty of Infectious and Tropical Diseases
Department of Clinical Research


TB Centre


I am  a tutor on the DL infectious Diseases tuberculosis module, and take part in face to face teaching in London when I am there as part of the DTM&H and AIDS module

I currently have 4 PhD students, Lily Telisinghe, Mohammed Limbada, Modupe Amofa-Sekyi and Mwelwa Phiri


I am the overall PI for the TREATS consortium which will evaluate the impact fo the PopART intervention on TB, looking at the incidence of TB infection in adolescents and the prevalence of active TB disease in adults. We will also be investigating the role of new diagnostic tools in TB surveys.

I am the PI for the Yathu Yathu (By us, for us) trial which was developed by our adolescent community advisory board members in Lusaka. This study will investigate the uptake of adolescent SRH services at community one-stop shops using innovative technology.

I was the Zambia PI for the PopART (HPTN 071) Trial which  investigated whether demonstrated that a strategy of universal test and treat for HIV reduced the incidence of HIV at community level. We are finishing analyses fromt hsi trial and some sub-studies

I was a site PI for the GSK/Aeras TB-018 study a phase IIb trial of a novel TB vaccine which demonstrated a 50% vaccine efficacy.

I am also an investigator in the UNITAID funded HIV self testing in Africa (STAR) Project

I am Director of Research at Zambart in Zambia. Zambart is an independent research NGO but is closely affiliated to both LSHTM and the University of Zambia School of Public Health in Lusaka, which houses the project. Zambart employs more than 600 staff working on our studies. We have state of the art laboratories for TB and HIV in Lusaka

Research Area
Clinical trials
Complex interventions
Health systems
Primary care
Public health
Adolescent health
Randomised controlled trials
Operational research
Disease and Health Conditions
Infectious disease
Non-communicable diseases
Tropical diseases
Sub-Saharan Africa (all income levels)

Selected Publications

A Comprehensive Genomics Solution for HIV Surveillance and Clinical Monitoring in Low-Income Settings.
Bonsall D; Golubchik T; de Cesare M; Limbada M; Kosloff B; MacIntyre-Cockett G; Hall M; Wymant C; Ansari MA; Abeler-Dörner L
Journal of clinical microbiology
Social response to the delivery of HIV self-testing in households: experiences from four Zambian HPTN 071 (PopART) urban communities.
Bwalya C; Simwinga M; Hensen B; Gwanu L; Hang'andu A; Mulubwa C; Phiri M; Hayes R; Fidler S; Mwinga A
AIDS Research and Therapy
Smoking and HIV associated with subclinical tuberculosis: analysis of a population-based prevalence survey.
Gunasekera K; Cohen T; Gao W; Ayles H; Godfrey-Faussett P; Claassens M
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
Who Accepts and Who Uses Community-Based Secondary Distribution HIV Self-Testing (HIVST) Kits? Findings From the Intervention Arm of a Cluster-Randomized Trial of HIVST Distribution Nested in Four HPTN 071 (PopART) Communities in Zambia.
Hensen B; Schaap AJ; Mulubwa C; Floyd S; Shanaube K; Phiri MM; Bond V; Bwalya C; Simwinga M; Fidler S
Journal of acquired immune deficiency syndromes (1999)
Association between HIV stigma and antiretroviral therapy adherence among adults living with HIV: baseline findings from the HPTN 071 (PopART) trial in Zambia and South Africa.
Jones HS; Floyd S; Stangl A; Bond V; Hoddinott G; Pliakas T; Bwalya J; Mandla N; Moore A; Donnell D
Tropical Medicine and International Health
Genital self-sampling compared with cervicovaginal lavage for the diagnosis of female genital schistosomiasis in Zambian women: The BILHIV study.
Sturt AS; Webb EL; Phiri CR; Mweene T; Chola N; van Dam GJ; Corstjens PLAM; Wessels E; Stothard JR; Hayes R
PLoS Neglected Tropical Diseases
Universal HIV testing and treatment and HIV stigma reduction: a comparative thematic analysis of qualitative data from the HPTN 071 (PopART) trial in South Africa and Zambia
Viljoen L; Bond VA; Reynolds LJ; Mubekapi‐Musadaidzwa C; Baloyi D; Ndubani R; Stangl A; Seeley J; Pliakas T; Bock P
Sociology of Health & Illness
See more Publications