Dr Helen Ayles
BSc MBBS MRCP DTM&H MSc PhD
of Infectious Diseases and International Health, Director of Research ZAMBART Project
I am a professor in the Clinical research Unit London School of Hygiene and Tropical Medicine and for the last 14 years have been Director of Research at Zambart, based full time in Lusaka Zambia.
I trained as a Physician in London and specialized in infectious and tropical diseases. I have worked as a clinician in UK, Uganda and Zambia and have over 20 years of developing country experience both in clinical TB/HIV management and epidemiology, leading Zambart that has conducted research into the dual TB/HIV epidemic for 20 years in Zambia.
My key research interests are in the fields of TB/HIV and the overlap between them. I have led a number of large cluster-randomised trials of complex public health interventions.
Other research grants and interests include: field evaluation of TB diagnostics, adolescent health, association of TB and NCD as well as operational research into the implementation of TB/HIV collaborative activities.
I am a tutor on the DL infectious Diseases tuberculosis module, and take part in face to face teaching in London when I am there as part of the DTM&H and AIDS module
I currently have 4 PhD students, Lily Telisinghe, Mohammed Limbada, Modupe Amofa-Sekyi and Mwelwa Phiri
I am the overall PI for the TREATS consortium which will evaluate the impact fo the PopART intervention on TB, looking at the incidence of TB infection in adolescents and the prevalence of active TB disease in adults. We will also be investigating the role of new diagnostic tools in TB surveys.
I am the PI for the Yathu Yathu (By us, for us) trial which was developed by our adolescent community advisory board members in Lusaka. This study will investigate the uptake of adolescent SRH services at community one-stop shops using innovative technology.
I was the Zambia PI for the PopART (HPTN 071) Trial which investigated whether demonstrated that a strategy of universal test and treat for HIV reduced the incidence of HIV at community level. We are finishing analyses fromt hsi trial and some sub-studies
I was a site PI for the GSK/Aeras TB-018 study a phase IIb trial of a novel TB vaccine which demonstrated a 50% vaccine efficacy.
I am also an investigator in the UNITAID funded HIV self testing in Africa (STAR) Project
I am Director of Research at Zambart in Zambia. Zambart is an independent research NGO but is closely affiliated to both LSHTM and the University of Zambia School of Public Health in Lusaka, which houses the project. Zambart employs more than 600 staff working on our studies. We have state of the art laboratories for TB and HIV in Lusaka