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Prof Helen Ayles

Clinical Professor (HCC)

United Kingdom

I am an infectious diseases clinician and epidemiologist, living and working in Zambia for over 20 years. My research interests are TB and HIV, with specific interests in diagnostics and the design and testing of interventions to reduce the impact of these two epidemics at population level.

Affiliations

Department of Clinical Research
Faculty of Infectious and Tropical Diseases

Centres

Centre for Evaluation

Teaching

I am involved in teaching in the DTM&H, the AIDS module and the DL TB module

Research

TB, HIV and other infectious diseases relevant at population level in lower income countries

Research Area
Adolescent health
Bacteria
Clinical trials
Complex interventions
Diagnostics
Global Health
Health systems
Sexual and reproductive health
Epidemiology
Medicine
Operational research
Implementation science
Virology
Disease and Health Conditions
Diabetes
HIV/AIDS
Neglected Tropical Diseases (NTDs)
Schistosomiasis
Tropical diseases
Tuberculosis
Infectious diseases
Emerging infectious diseases
Sexually transmitted infections
Country
South Africa
Zambia
Region
Sub-Saharan Africa (all income levels)

Selected Publications

Population-level viremia predicts HIV incidence at the community level across the Universal Testing and Treatment Trials in eastern and southern Africa.
Larmarange, J; Bachanas, P; Skalland, T; Balzer, LB; Iwuji, C; FLOYD, S; Mills, LA; Pillay, D; Havlir, D; Kamya, MR; AYLES, H; Wirth, K; Dabis, F; HAYES, R; Petersen, M; UT³C consortium,;
2023
PLOS global public health
The impact of a combined TB/HIV intervention on the incidence of TB infection among adolescents and young adults in the HPTN 071 (PopART) trial communities in Zambia and South Africa.
Shanaube, K; Schaap, A; Mureithi, L; Amofa-Sekyi, M; Paulsen, R; Cheeba, M; Kangololo, B; Vermaak, R; Sisam, C; Kosloff, B; De Haas, P; Fidler, S; RUPEREZ, M; HAYES, R; FLOYD, S; AYLES, H; TREATS Study Team,;
2023
PLOS global public health
Use of point-of-care C-reactive protein testing for screening of tuberculosis in the community in high-burden settings: a prospective, cross-sectional study in Zambia and South Africa.
RUPEREZ, M; Shanaube, K; Mureithi, L; Wapamesa, C; Burnett, MJ; Kosloff, B; De Haas, P; HAYES, R; Fidler, S; GACHIE, T; SCHAAP, A; FLOYD, S; Klinkenberg, E; AYLES, H; TREATS study team,;
2023
The Lancet. Global health
The impact of community-based, peer-led sexual and reproductive health services on knowledge of HIV status among adolescents and young people aged 15 to 24 in Lusaka, Zambia: The Yathu Yathu cluster-randomised trial.
Hensen, B; FLOYD, S; PHIRI, MM; SCHAAP, A; Sigande, L; Simuyaba, M; Mwenge, L; Zulu-Phiri, R; Mwape, L; Fidler, S; HAYES, R; Simwinga, M; AYLES, H;
2023
PLoS medicine
Viral suppression and self-reported ART adherence after 3 years of universal testing and treatment in the HPTN 071 (PopART) community-randomised trial in Zambia and South Africa: a cross-sectional analysis.
MACLEOD, D; Shanaube, K; Skalland, T; Limbada, M; Mandla, N; Bwalya, J; SCHAAP, A; Yang, B; Donnell, D; Piwowar-Manning, E; Eshleman, SH; Hoddinott, G; BOND, V; Moore, A; Griffith, S; Bock, P; AYLES, H; Fidler, S; HAYES, R; FLOYD, S; HPTN 071 (PopART) Study Team,;
2022
The Lancet. HIV
Projected outcomes of universal testing and treatment in a generalised HIV epidemic in Zambia and South Africa (the HPTN 071 [PopART] trial): a modelling study.
Probert, WJ M; Sauter, R; Pickles, M; Cori, A; Bell-Mandla, NF; Bwalya, J; Abeler-Dörner, L; Bock, P; Donnell, DJ; FLOYD, S; MACLEOD, D; Piwowar-Manning, E; Skalland, T; Shanaube, K; Wilson, E; Yang, B; AYLES, H; Fidler, S; HAYES, RJ; Fraser, C; HPTN 071 (PopART) Study Team,;
2022
The lancet. HIV
Impact of universal testing and treatment on sexual risk behaviour and herpes simplex virus type 2: a prespecified secondary outcomes analysis of the HPTN 071 (PopART) community-randomised trial.
Wilson, E; Donnell, D; Skalland, T; FLOYD, S; Moore, A; Bell-Mandla, N; Bwalya, J; Kasese, N; Dunbar, R; Shanaube, K; Kosloff, B; Laeyendecker, O; Agyei, Y; Hoddinott, G; Bock, P; Fidler, S; HAYES, R; AYLES, H; HPTN 071 (PopART) Study Team,;
2022
The lancet HIV
Optimising Xpert-Ultra and culture testing to reliably measure tuberculosis prevalence in the community: findings from surveys in Zambia and South Africa.
FLOYD, S; Klinkenberg, E; De Haas, P; Kosloff, B; GACHIE, T; Dodd, PJ; RUPEREZ, M; Wapamesa, C; Burnett, MJ; Kalisvaart, N; Vermaak, R; Mainga, T; SCHAAP, A; Fidler, S; Mureithi, L; Shanaube, K; HAYES, R; AYLES, H; TREATS study team,;
2022
BMJ Open
Rates of viral suppression in a cohort of people with stable HIV from two community models of ART delivery versus facility-based HIV care in Lusaka, Zambia: a cluster-randomised, non-inferiority trial nested in the HPTN 071 (PopART) trial.
Limbada, M; MACLEOD, D; Situmbeko, V; Muhau, E; Shibwela, O; Chiti, B; FLOYD, S; SCHAAP, AJ; HAYES, R; Fidler, S; AYLES, H; HPTN 071 (PopART) study team,;
2021
The lancet. HIV
A Comprehensive Genomics Solution for HIV Surveillance and Clinical Monitoring in Low-Income Settings.
Bonsall, D; Golubchik, T; De Cesare, M; LIMBADA, M; Kosloff, B; MacIntyre-Cockett, G; Hall, M; Wymant, C; Ansari, MA; Abeler-Dörner, L; SCHAAP, A; Brown, A; Barnes, E; Piwowar-Manning, E; Eshleman, S; Wilson, E; Emel, L; HAYES, R; Fidler, S; AYLES, H; Bowden, R; Fraser, C; HPTN 071 (PopART) Team,;
2020
JOURNAL OF CLINICAL MICROBIOLOGY
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