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Weight-for-age z-score as a proxy marker for diarrhoea in epidemiological studies.

J Epidemiol Community Health, 2009;
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Centre for Maternal, Reproductive and Child Health (MARCH)

pub_id
19955098
pubmedid
19955098
ISI
284937000010
reference_type
author
Schmidt, W.P.; Boisson, S.; Genser, B.; Barreto, M.; Baisley, K.; Filteau, S.; Cairncross, S.;
title
Weight-for-age z-score as a proxy marker for diarrhoea in epidemiological studies.
secondary_title
J Epidemiol Community Health
ISBNISSN
1470-2738
volume
number
pages
year
2009
abstract
BACKGROUND: The validity of unblinded randomised trials testing interventions against diarrhoea is severely compromised by the potential bias. Objective proxy markers for diarrhoea not relying on self-report are needed to assess the effect of interventions that cannot be blinded. Short term changes in weight for age z-score (WAZ) may (due to catch-up growth) not be a clinically important marker for nutritional status. However, even a transient decrease in WAZ could indicate recent diarrhoea, and be interpreted as the effect of an intervention. METHODS: Using data from two large Vitamin A trials from Ghana and Brazil, we explored the immediate effect of the cumulative diarrhoea occurrence over 14 and 28 day time windows on WAZ. RESULTS: We found a very strong linear association between the number of days with diarrhoea over the last 14 to 28 days and WAZ. In both trials, differences in diarrhoea between the trial arms were associated with corresponding differences in WAZ. CONCLUSION: Repeated WAZ measures appear to be a suitable proxy marker for diarrhoea in children, but have disadvantages in terms of specificity and study power.
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secondary_author
place_published
publisher
number_of_volumes
tertiary_author
tertiary_title
edition
date
type_of_work
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alternate_title
call_number
accession_number
custom_1
WOS OK
custom_2
Unknown
custom_3
custom_4
10.1136/jech.2009.099721
custom_5
PMC
custom_6
10
label
2016-10-18
notes
JOURNAL ARTICLE
url
author_address
United Kingdom;
library
jech.2009.099721 10.1136/jech.2009.099721 19955098
date_accepted
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created
2010-01-08 15:10:30
modified
2016-07-08 00:00:00
library

<ArticleId IdType="pii">jech.2009.099721</ArticleId>
<ArticleId IdType="doi">10.1136/jech.2009.099721</ArticleId>
<ArticleId IdType="pubmed">19955098</ArticleId>