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Recent diarrhoeal illness and risk of lower respiratory infections in children under the age of 5 years.

Schmidt, W.P.; Cairncross, S.; Barreto, M.L.; Clasen, T.; Genser, B.;
Int J Epidemiol, 2009; 38(3):766-72
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pub_id
19279073
pubmedid
19279073
ISI
268810100024
reference_type
author
Schmidt, W.P.; Cairncross, S.; Barreto, M.L.; Clasen, T.; Genser, B.;
title
Recent diarrhoeal illness and risk of lower respiratory infections in children under the age of 5 years.
secondary_title
Int J Epidemiol
ISBNISSN
1464-3685
volume
38
number
3
pages
766-72
year
2009
abstract
BACKGROUND: Children in low-income settings suffering from frequent diarrhoea episodes are also at a high risk of acute lower respiratory infections (ALRI). We explored whether this is due to common risk factors for both conditions or whether diarrhoea can increase the risk of ALRI directly. METHODS: We used a dynamic time-to-event analysis of data from two large child studies in low-income settings in Ghana and Brazil, with the cumulative diarrhoea prevalence over 2 weeks as the exposure and severe ALRI as outcome. The analysis was adjusted for baseline risk of ALRI and diarrhoea, seasonality and age. RESULTS: The child population from Ghana had a much higher risk of diarrhoea, malnutrition and death than the children in Brazil. In the data from Ghana, every additional day of diarrhoea within 2 weeks increased the risk of ALRI by a factor of 1.08 (95% CI 1.00-1.15). In addition, we found a roughly linear relationship between the number of diarrhoea days over the last 28 days and the risk of ALRI. In the Ghana data, 26% of ALRI episodes may be due to recent exposure to diarrhoea. The Brazilian data gave no evidence for an association between diarrhoea and ALRI. CONCLUSION: Diarrhoea may contribute substantially to the burden of ALRI in malnourished child populations.
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secondary_author
place_published
publisher
number_of_volumes
tertiary_author
tertiary_title
edition
date
type_of_work
subsidiary_author
alternate_title
call_number
accession_number
custom_1
WOS NEW
custom_2
Unknown
custom_3
custom_4
10.1093/ije/dyp159
custom_5
PMC
custom_6
10
label
2016-10-18
notes
Journal Article
url
author_address
Department for Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK. Wolf-Peter.Schmidt@lshtm.ac.uk
library
dyp159 10.1093/ije/dyp159 19279073 PMC2689396
date_accepted
date_online
created
2009-03-13 14:18:36
modified
2016-07-08 00:00:00
library

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<ArticleId IdType="doi">10.1093/ije/dyp159</ArticleId>
<ArticleId IdType="pubmed">19279073</ArticleId>
<ArticleId IdType="pmc">PMC2689396</ArticleId>