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Serotonin - A link between disgust and immunity?

Rubio-Godoy, M.; Aunger, R.; Curtis, V.
Medical Hypotheses, 2007; 68(1):61-6
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pub_id
16928421
pubmedid
16928421
ISI
242654200009
reference_type
Journal Article
author
Rubio-Godoy, M.; Aunger, R.; Curtis, V.
title
Serotonin - A link between disgust and immunity?
secondary_title
Medical Hypotheses
ISBNISSN
0306-9877
volume
68
number
1
pages
61-6
year
2007
abstract
Immune systems maintain the integrity of organisms by recognising and attacking foreign substances and/or pathogens. However, immune defences can only take place following direct contact with threats. Disgust can prevent infection before contact with potential pathogens: we propose that disgust is an evolved nervous response to a signal reliably co-occurring with infectious environmental disease threats, which motivates behaviour leading to the avoidance of infection. We hypothesize that disgust and immunity form a defensive continuum with overlaps: disgust acts prior to contact with the infectious agent and prevents it from getting into the body; emesis (vomiting) gets it out once inside the gastrointestinal tract, before penetration of the body boundaries; and immunity expels or kills infectious threats following penetration of the body proper. We further propose that serotonin (5-hydroxytryptamine, 5-HT) might be the link between disgust and immunity. 5-HT plays a central role in the induction of the emetic reflex and is possibly involved in the development of learned aversion; it is also a signal used by immune cells and modulates both innate and acquired immunity. We therefore propose 5-HT might mediate the interaction between these two defensive mechanisms.
keywords
CAENORHABDITIS-ELEGANS; EMETIC REFLEX; CELLS; GUT; LYMPHOCYTES; MEDIATOR; BEHAVIOR; FORM; TERM
secondary_author
place_published
publisher
number_of_volumes
tertiary_author
tertiary_title
edition
date
type_of_work
Article
subsidiary_author
alternate_title
Med Hypotheses
call_number
accession_number
16928421
custom_1
WOS OK
custom_2
Unknown
custom_3
custom_4
10.1016/j.mehy.2006.06.036
custom_5
Subscription Required
custom_6
10
label
2016-10-18
notes
Journal Article
url
://000242654200009 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16928421
author_address
Instituto de Ecología, A.C., km 2.5 ant Carretera a Coatepec, Xalapa, Veracruz 91070, Mexico. mrubio@ecologia.edu.mx
library
S0306-9877(06)00494-4 10.1016/j.mehy.2006.06.036 16928421
date_accepted
date_online
created
2007-01-16 13:22:40
modified
2016-07-08 00:00:00
library

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<ArticleId IdType="doi">10.1016/j.mehy.2006.06.036</ArticleId>
<ArticleId IdType="pubmed">16928421</ArticleId>