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The intensity of transmission of hepatitis A and heterogeneities in socio-environmental risk factors in Rio de Janeiro, Brazil

de Almeida, L. M.; Amaku, M.; Azevedo, R. S.; Cairncross, S.; Massad, E.
Trans R Soc Trop Med Hyg, 2002; 96(6):605-10
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pub_id
12625132
pubmedid
12625132
ISI
reference_type
Journal Article
author
de Almeida, L. M.; Amaku, M.; Azevedo, R. S.; Cairncross, S.; Massad, E.
title
The intensity of transmission of hepatitis A and heterogeneities in socio-environmental risk factors in Rio de Janeiro, Brazil
secondary_title
Trans R Soc Trop Med Hyg
ISBNISSN
0035-9203
volume
96
number
6
pages
605-10
year
2002
abstract
The objective of this work was to assess the intensity of transmission of hepatitis A in Rio de Janeiro, Brazil. We also used the estimation of the parameters of a deterministic model to study the effects of risk factors. Age-specific seroprevalence of antibodies against hepatitis A virus (HAV) was obtained from a survey screening in a city of the metropolitan area of Rio de Janeiro, in 1997. From the seroprevalence data, we estimated the age-dependent force of infection (lambda) and the average age of first infection (A), using a deterministic model. To evaluate the influence of the environmental risk factors, we estimated the same parameters stratifying the sample for the selected socio-environmental risk factors: the number of years of schooling of the female responsible for the house, crowding within the bedroom, number of water taps and fittings, and the presence of sewage in front of the house. For the whole sample, the maximum force of infection estimated was 0.12/year and the average age of infection was 10.1 years. This last parameter decreased as the number of persons per bedroom increased, and also when the number of water taps and the number of years of schooling of the woman responsible for the house decreased. The proposed environmental interventions may lead to a decrease in the intensity of transmission of HAV and an increase in the average age of first infection in the next few years. This may have public health implications, since hepatitis A is more severe in adults. In this context, specific vaccination programmes may be necessary, as in developed countries.
keywords
Adolescent Adult Aged Aged, 80 and over Brazil/epidemiology Child Child, Preschool Crowding Female Hepatitis A/epidemiology/*transmission Human Infant Male Middle Age Risk Factors Socioeconomic Factors Support, Non-U.S. Gov't
secondary_author
place_published
publisher
number_of_volumes
tertiary_author
tertiary_title
edition
date
Nov-Dec
type_of_work
subsidiary_author
alternate_title
call_number
accession_number
12625132
custom_1
WOS_DUP
custom_2
Unknown
custom_3
custom_4
10.1016/S0035-9203(02)90325-1
custom_5
custom_6
10
label
2016-10-19
notes
Journal Article
url
author_address
Núcleo de Estudos de Saúde Coletiva, Universidade Federal do Rio de Janeiro, Av. Brig. Trompowski, s/n, HUCFF, 5o andar/Ala Sul, sala 25, Ilha do Fundão, 21941-590 Rio de Janeiro, RJ, Brazil.
library
12625132
date_accepted
date_online
created
2003-11-28 14:06:56
modified
2016-07-08 00:00:00
library

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