You are here: Home > Research > Publications > Full record view

Full record view

Back to list

Associations of common variants at 1p11.2 and 14q24.1 (RAD51L1) with breast cancer risk and heterogeneity by tumor subtype: findings from the Breast Cancer Association Consortium.

Figueroa, J.D. ; Garcia-Closas, M. ; Humphreys, M. ; Platte, R. ; Hopper, J.L. ; Southey, M.C. ; Apicella, C. ; Hammet, F. ; Schmidt, M.K. ; Broeks, A. ; Tollenaar, R.A. ; Van't Veer, L.J. ; Fasching, P.A. ; Beckmann, M.W. ; Ekici, A.B. ; Strick, R. ; Peto, J. ; Dos Santos Silva, I. ; Fletcher, O. ; Johnson, N. ; Sawyer, E. ; Tomlinson, I. ; Kerin, M. ; Burwinkel, B. ; Marme, F. ; Schneeweiss, A. ; Sohn, C. ; Bojesen, S. ; Flyger, H. ; Nordestgaard, B.G. ; Benítez, J. ; Milne, R.L. ; Ignacio Arias, J. ; Zamora, M.P. ; Brenner, H. ; Müller, H. ; Arndt, V. ; Rahman, N. ; Turnbull, C. ; Seal, S. ; Renwick, A. ; Brauch, H. ; Justenhoven, C. ; Brüning, T. ; The GENICA Network, . ; Chang-Claude, J. ; Hein, R. ; Wang-Gohrke, S. ; Dörk, T. ; Schürmann, P. ; Bremer, M. ; Hillemanns, P. ; Nevanlinna, H. ; Heikkinen, T. ; Aittomäki, K. ; Blomqvist, C. ; Bogdanova, N. ; Antonenkova, N. ; Rogov, Y.I. ; Karstens, J.H. ; Bermisheva, M. ; Prokofieva, D. ; Hanafievich Gantcev, S. ; Khusnutdinova, E. ; Lindblom, A. ; Margolin, S. ; Chenevix-Trench, G. ; Beesley, J. ; Chen, X. ; for the kConFab AOCS Management Group, . ; Mannermaa, A. ; Kosma, V.M. ; Soini, Y. ; Kataja, V. ; Lambrechts, D. ; Yesilyurt, B.T. ; Chrisiaens, M.R. ; Peeters, S. ; Radice, P. ; Peterlongo, P. ; Manoukian, S. ; Barile, M. ; Couch, F. ; Lee, A.M. ; Diasio, R. ; Wang, X. ; Giles, G.G. ; Severi, G. ; Baglietto, L. ; Maclean, C. ; Offit, K. ; Robson, M. ; Joseph, V. ; Gaudet, M. ; John, E.M. ; Winqvist, R. ; Pylkäs, K. ; Jukkola-Vuorinen, A. ; Grip, M. ; Andrulis, I. ; Knight, J.A. ; Marie Mulligan, A. ; O'Malley, F.P. ; Brinton, L.A. ; Sherman, M.E. ; Lissowska, J. ; Chanock, S.J. ; Hooning, M. ; Martens, J.W. ; van den Ouweland, A.M. ; Collée, J.M. ; Hall, P. ; Czene, K. ; Cox, A. ; Brock, I.W. ; Reed, M.W. ; Cross, S.S. ; Pharoah, P. ; Dunning, A.M. ; Kang, D. ; Yoo, K.Y. ; Noh, D.Y. ; Ahn, S.H. ; Jakubowska, A. ; Lubinski, J. ; Jaworska, K. ; Durda, K. ; Sangrajrang, S. ; Gaborieau, V. ; Brennan, P. ; McKay, J. ; Shen, C.Y. ; Ding, S.L. ; Hsu, H.M. ; Yu, J.C. ; Anton-Culver, H. ; Ziogas, A. ; Ashworth, A. ; Swerdlow, A. ; Jones, M. ; Orr, N. ; Trentham-Dietz, A. ; Egan, K. ; Newcomb, P. ; Titus-Ernstoff, L. ; Easton, D. ; Spurdle, A.B. ;
Hum Mol Genet, 2011;
Edit
Delete
Code Authors

pub_id
21852249
pubmedid
21852249
ISI
297049600015
reference_type
author
Figueroa, J.D. ; Garcia-Closas, M. ; Humphreys, M. ; Platte, R. ; Hopper, J.L. ; Southey, M.C. ; Apicella, C. ; Hammet, F. ; Schmidt, M.K. ; Broeks, A. ; Tollenaar, R.A. ; Van't Veer, L.J. ; Fasching, P.A. ; Beckmann, M.W. ; Ekici, A.B. ; Strick, R. ; Peto, J. ; Dos Santos Silva, I. ; Fletcher, O. ; Johnson, N. ; Sawyer, E. ; Tomlinson, I. ; Kerin, M. ; Burwinkel, B. ; Marme, F. ; Schneeweiss, A. ; Sohn, C. ; Bojesen, S. ; Flyger, H. ; Nordestgaard, B.G. ; Benítez, J. ; Milne, R.L. ; Ignacio Arias, J. ; Zamora, M.P. ; Brenner, H. ; Müller, H. ; Arndt, V. ; Rahman, N. ; Turnbull, C. ; Seal, S. ; Renwick, A. ; Brauch, H. ; Justenhoven, C. ; Brüning, T. ; The GENICA Network, . ; Chang-Claude, J. ; Hein, R. ; Wang-Gohrke, S. ; Dörk, T. ; Schürmann, P. ; Bremer, M. ; Hillemanns, P. ; Nevanlinna, H. ; Heikkinen, T. ; Aittomäki, K. ; Blomqvist, C. ; Bogdanova, N. ; Antonenkova, N. ; Rogov, Y.I. ; Karstens, J.H. ; Bermisheva, M. ; Prokofieva, D. ; Hanafievich Gantcev, S. ; Khusnutdinova, E. ; Lindblom, A. ; Margolin, S. ; Chenevix-Trench, G. ; Beesley, J. ; Chen, X. ; for the kConFab AOCS Management Group, . ; Mannermaa, A. ; Kosma, V.M. ; Soini, Y. ; Kataja, V. ; Lambrechts, D. ; Yesilyurt, B.T. ; Chrisiaens, M.R. ; Peeters, S. ; Radice, P. ; Peterlongo, P. ; Manoukian, S. ; Barile, M. ; Couch, F. ; Lee, A.M. ; Diasio, R. ; Wang, X. ; Giles, G.G. ; Severi, G. ; Baglietto, L. ; Maclean, C. ; Offit, K. ; Robson, M. ; Joseph, V. ; Gaudet, M. ; John, E.M. ; Winqvist, R. ; Pylkäs, K. ; Jukkola-Vuorinen, A. ; Grip, M. ; Andrulis, I. ; Knight, J.A. ; Marie Mulligan, A. ; O'Malley, F.P. ; Brinton, L.A. ; Sherman, M.E. ; Lissowska, J. ; Chanock, S.J. ; Hooning, M. ; Martens, J.W. ; van den Ouweland, A.M. ; Collée, J.M. ; Hall, P. ; Czene, K. ; Cox, A. ; Brock, I.W. ; Reed, M.W. ; Cross, S.S. ; Pharoah, P. ; Dunning, A.M. ; Kang, D. ; Yoo, K.Y. ; Noh, D.Y. ; Ahn, S.H. ; Jakubowska, A. ; Lubinski, J. ; Jaworska, K. ; Durda, K. ; Sangrajrang, S. ; Gaborieau, V. ; Brennan, P. ; McKay, J. ; Shen, C.Y. ; Ding, S.L. ; Hsu, H.M. ; Yu, J.C. ; Anton-Culver, H. ; Ziogas, A. ; Ashworth, A. ; Swerdlow, A. ; Jones, M. ; Orr, N. ; Trentham-Dietz, A. ; Egan, K. ; Newcomb, P. ; Titus-Ernstoff, L. ; Easton, D. ; Spurdle, A.B. ;
title
Associations of common variants at 1p11.2 and 14q24.1 (RAD51L1) with breast cancer risk and heterogeneity by tumor subtype: findings from the Breast Cancer Association Consortium.
secondary_title
Hum Mol Genet
ISBNISSN
1460-2083
volume
number
pages
year
2011
abstract
A genome-wide association study (GWAS) identified single-nucleotide polymorphisms (SNPs) at 1p11.2 and 14q24.1 (RAD51L1) as breast cancer susceptibility loci. The initial GWAS suggested stronger effects for both loci for estrogen receptor (ER)-positive tumors. Using data from the Breast Cancer Association Consortium (BCAC), we sought to determine whether risks differ by ER, progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), grade, node status, tumor size, and ductal or lobular morphology. We genotyped rs11249433 at 1p.11.2, and two highly correlated SNPs rs999737 and rs10483813 (r(2)= 0.98) at 14q24.1 (RAD51L1), for up to 46 036 invasive breast cancer cases and 46 930 controls from 39 studies. Analyses by tumor characteristics focused on subjects reporting to be white women of European ancestry and were based on 25 458 cases, of which 87% had ER data. The SNP at 1p11.2 showed significantly stronger associations with ER-positive tumors [per-allele odds ratio (OR) for ER-positive tumors was 1.13, 95% CI = 1.10-1.16 and, for ER-negative tumors, OR was 1.03, 95% CI = 0.98-1.07, case-only P-heterogeneity = 7.6 × 10(-5)]. The association with ER-positive tumors was stronger for tumors of lower grade (case-only P= 6.7 × 10(-3)) and lobular histology (case-only P= 0.01). SNPs at 14q24.1 were associated with risk for most tumor subtypes evaluated, including triple-negative breast cancers, which has not been described previously. Our results underscore the need for large pooling efforts with tumor pathology data to help refine risk estimates for SNP associations with susceptibility to different subtypes of breast cancer.
keywords
secondary_author
place_published
publisher
number_of_volumes
tertiary_author
tertiary_title
edition
date
type_of_work
subsidiary_author
alternate_title
call_number
accession_number
custom_1
WOS OK
custom_2
1
custom_3
custom_4
10.1093/hmg/ddr368
custom_5
custom_6
10
label
2014-06-29
notes
JOURNAL ARTICLE
url
author_address
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
library
ddr368 10.1093/hmg/ddr368 21852249
created
2011-09-27 08:37:31
modified
2014-06-29 10:06:37
library

<ArticleId IdType="pii">ddr368</ArticleId>
<ArticleId IdType="doi">10.1093/hmg/ddr368</ArticleId>
<ArticleId IdType="pubmed">21852249</ArticleId>