Neonatal infection with G10P rotavirus did not confer protection against subsequent rotavirus infection in a community cohort in Vellore, South India.
Banerjee, I.; Gladstone, B.P.; Le Fevre, A.M.; Ramani, S.; Iturriza-Gomara, M.; Gray, J.J.; Brown, D.W.; Estes, M.K.; Muliyil, J.P.; Jaffar, S.; Kang, G.;
J Infect Dis, 2007; 195(5):625-32
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BACKGROUND: Various observational studies have suggested that neonatal rotavirus infection confers protection against diarrhea due to subsequent rotavirus infection. We examined the incidence of rotavirus infection and diarrhea during the first 2 years of life among children infected with the G10P rotavirus strain during the neonatal period and those not infected with rotavirus. METHODS: Children were recruited at birth and were followed up at least twice weekly. Stool samples, collected every 2 weeks for surveillance and at each episode of diarrhea, were screened by enzyme-linked immunosorbent assay and were genotyped by polymerase chain reaction. RESULTS: Among 33 children infected neonatally with G10P and 300 children not infected with rotavirus, there was no significant difference in the rates of rotavirus-positive diarrhea (rate ratio [RR], 1.05 [95% confidence interval [CI], 0.61-1.79]), moderate or severe rotavirus-positive diarrhea (RR, 1.42 [95% CI, 0.73-2.78]), or asymptomatic rotavirus shedding (RR, 1.25 [95% CI, 0.85-1.83]). CONCLUSION: Neonatal G10P infection with a strain resembling a vaccine candidate did not confer protection against subsequent rotavirus infection or diarrhea of any severity in this setting.