PMBU Research on Trypanosomatids

Trypanosomatids are protozoa responsible for a variety of human diseases, including Chagas' disease (caused by Trypanosoma cruzi), leishmaniasis (caused by several species of the genus Leishmania), and African sleeping sickness (caused by Trypanosoma brucei).

Three PMBU labs are focusing on this parasite:

Laboratory of Professor Michael Miles:

	Genetic diversity of Trypanosoma cruzi and the epidemiology of Chagas disease

	Molecular taxonomy and phylogeny of the Leishmania donovani complex, and implications for epidemiological and clinical research

	Genetic diversity and recombination in the Leishmania subgenus Viannia, agents of cutaneous and mucocutaneous leishmaniasis

Laboratory of Dr. John Kelly:

	Functional studies on detoxification systems which protect parasites from oxidative stress

	The mechanisms of chromosome segregation in parasitic protozoa: the role of the centromere

Laboratory of Dr. David Horn:

	Horn Lab Website - Research

	Histone modification in Trypanosoma brucei

	Telomere biology in Trypanosoma brucei