Background
Brendan Wren joined the School with his research team in July 1999. His research interests include determining the genetic basis by which bacteria cause disease. The research group exploits a range of post genome research strategies to gain a comprehensive understanding of how these pathogens function and how they interact with their respective hosts.
Teaching
Brendan Wren is chair of the board of examiners for the MSc in Medical Microbiology (MM) and also lectures on this course. In addition he is Research Degrees Director for the Department.
Research
Current research focuses on:
1. Glycosylation in bacterial pathogens, glycoprospecting and glycoengineering
2. Comparative phylogenomics and the evolution of bacterial virulence
3. Systems biology of host pathogen interactions
Research on individual pathogens include; Campylobacter jejuni, Helicobacter pylori, Clostridium difficile, Burkholderia pseudomallei and the enteropathogenic Yersinia.
Campylobacter Resource Facility link. Selected publications
- Pallen, M.J.; Wren, B.W. Bacterial pathogenomics Nature, 2007; 449(7164):835-842
- Sebaihia, M.; Wren, B. W.; Mullany, P.; Fairweather, N. F.; Minton, N.; Stabler, R.; Thomson, N. R.; Roberts, A. P.; Cerdeno-Tarrraga, A. M.; Wang, H. W.; Holden, M. T. G.; Wright, A.; Churcher, C.; Quail, M. A.; Baker, S.; Bason, N.; Brooks, K.; Chillingworth, T.; Cronin, A.; Davis, P.; Dowd, L.; Fraser, A.; Feltwell, T.; Hance, Z.; Holroyd, S.; Jagels, K.; Moule, S.; Mungall, K.; Price, C.; Rabbinowitsch, E.; Sharp, S.; Simmonds, M.; Stevens, K.; Unwin, L.; Whithead, S.; Dupuy, B.; Dougan, G.; Barrell, B.; Parkhill, J. The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome Nature Genetics, 2006; 38(7):779-786
- Champion, O.L.; Gaunt, M.W.; Gundogdu, O.; Elmi, A.; Witney, A.A.; Hinds, J.; Dorrell, N.; Wren, B.W.; Comparative phylogenomics of the food-borne pathogen Campylobacter jejuni reveals genetic markers predictive of infection source. Proc Natl Acad Sci U S A, 2005; 102(44):16043-8
- Linton, D.; Dorrell, N.; Hitchen, P.G.; Amber, S.; Karlyshev, A.V.; Morris, H.R.; Dell, A.; Valvano, M.A.; Aebi, M.; Wren, B.W.; Functional analysis of the Campylobacter jejuni N-linked protein glycosylation pathway. Mol Microbiol, 2005; 55(6):1695-1703
- Szymanski, C.M.; Wren, B.W.; Protein glycosylation in bacterial mucosal pathogens. Nat Rev Microbiol, 2005; 3(3):225-37
- Hinchliffe, S. J.; Isherwood, K. E.; Stabler, R. A.; Prentice, M. B.; Rakin, A.; Nichols, R. A.; Oyston, P. C.; Hinds, J.; Titball, R. W.; Wren, B. W. Application of DNA microarrays to study the evolutionary genomics of Yersinia pestis and Yersinia pseudotuberculosis Genome Research, 2003; 13(9):2018-29
- Wacker, M.; Linton, D.; Hitchen, P. G.; Nita-Lazar, M.; Haslam, S. M.; North, S. J.; Panico, M.; Morris, H. R.; Dell, A.; Wren, B. W.; Aebi, M. N-linked glycosylation in Campylobacter jejuni and its functional transfer into E-coli Science, 2002; 298(5599):1790-1793
- Parkhill, J.; Wren, B. W.; Thomson, N. R.; Titball, R. W.; Holden, M. T. G.; Prentice, M. B.; Sebaihia, M.; James, K. D.; Churcher, C.; Mungall, K. L.; Baker, S.; Basham, D.; Bentley, S. D.; Brooks, K.; Cerdeno-Tarraga, A. M.; Chillingworth, T.; Cronin, A.; Davies, R. M.; Davis, P.; Dougan, G.; Feltwell, T.; Hamlin, N.; Holroyd, S.; Jagels, K.; Karlyshev, A. V.; Leather, S.; Moule, S.; Oyston, P. C. F.; Quail, M.; Rutherford, K.; Simmonds, M.; Skelton, J.; Stevens, K.; Whitehead, S.; Barrell, B. G. Genome sequence of Yersinia pestis, the causative agent of plague Nature, 2001; 413(6855):523-527
Full publications listing (since 2001) |
