John Whittaker

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Background

My training is in statistics, and I have worked mainly on statistical problems in medicine and biology, particularly genetics.

I joined the School in April 2005, having worked previously at Imperial College London and the University of Reading. Since April 2009 I have been Director, Statistical Genetics at GlaxoSmithKline, but retain a 10% appointment at .the School.

Research

My research interests are in the application of statistics in human, population and quantitative genetics. In particular I have published widely on the design and analysis of genetic association studies, both population and family based. This research has been a mixture of methodological development and applied data analytic work in collaboration with data generators.

Selected publications

• Verzilli, C.; Shah, T.; Casas, J.P.; Chapman, J.; Sandhu, M.; Debenham, S.L.; Boekholdt, M.S.; Khaw, K.T.; Wareham, N.J.; Judson, R.; Benjamin, E.J.; Kathiresan, S.; Larson, M.G.; Rong, J.; Sofat, R.; Humphries, S.E.; Smeeth, L.; Cavalleri, G.; Whittaker, J.C.; Hingorani, A.D.; Bayesian meta-analysis of genetic association studies with different sets of markers. Am J Hum Genet, 2008; 82(4):859-72
• Graham, D.S.; Graham, R.R.; Manku, H.; Wong, A.K.; Whittaker, J.C.; Gaffney, P.M.; Moser, K.L.; Rioux, J.D.; Altshuler, D.; Behrens, T.W.; Vyse, T.J.; Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus. Nat Genet, 2008; 40(1):83-9
• Chapman, J.; Whittaker, J.; Analysis of multiple SNPs in a candidate gene or region. Genet Epidemiol, 2008; 32(6):560-6
• Verzilli, C. J.; Stallard, N.; Whittaker, J. C. Bayesian graphical models for genomewide association studies American Journal of Human Genetics, 2006; 79(1):100-112
• Lunn, D.J.; Whittaker, J.C.; Best, N.; A Bayesian toolkit for genetic association studies. Genet Epidemiol, 2006; 30(3):231-47
• Hubner, N.; Wallace, C.A.; Zimdahl, H.; Petretto, E.; Schulz, H.; Maciver, F.; Mueller, M.; Hummel, O.; Monti, J.; Zidek, V.; Musilova, A.; Kren, V.; Causton, H.; Game, L.; Born, G.; Schmidt, S.; Müller, A.; Cook, S.A.; Kurtz, T.W.; Whittaker, J.; Pravenec, M.; Aitman, T.J.; Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease. Nat Genet, 2005; 37(3):243-53
• Russell, A.I.; Cunninghame Graham, D.S.; Shepherd, C.; Roberton, C.A.; Whittaker, J.; Meeks, J.; Powell, R.J.; Isenberg, D.A.; Walport, M.J.; Vyse, T.J.; Polymorphism at the C-reactive protein locus influences gene expression and predisposes to systemic lupus erythematosus. Hum Mol Genet, 2004; 13(1):137-47
• Barton, S.J.; Richardson, S.; Perkins, D.N.; Bellahn, I.; Bryant, T.N.; Whittaker, J.C.; Using Statistical Models To Identify Factors That Have a Role in Defining the Abundance of Ions Produced by Tandem MS. Anal Chem, 2007; 79(15):5601-5607

Full publications listing (since 2001)