Juan Pablo Casas MD PhD

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Background

I trained in medicine in Colombia (1999) and continue to train in cardiovascular science. In the UK, I worked initially as a Research Fellow in Centre for Clinical Pharmacology at UCL and joined LSHTM in April 2005. From April 2009 I am Deputy-Editor of the Cochrane Heart Group

Teaching

I currently teach on extended epidemiology, design and analyses of epidemiological studies and collaborate with genetic epidemiology. I am also the co-organizer of the non-communicable disease epidemioloy unit.

Research

My major interest is in disease aetiology in non-communicable disease with focus on cardiovascular disease and pre-eclampsia.

Since 1999 with Dr. Serrano, we set-up the GenPE study, a case-control study in pre-eclampsia. This study is on-going and aim to recruit 4000 cases and similar number of controls (www.genpe.org). In 2008 I was awarded a Wellcome Trust grant to conduct a genome-wide association study in Pre-eclampsia, under the umbrella of the WTCCC2 (http://www.wtccc.org.uk/ccc2/wtccc2_studies.shtml).

In collaboration with Dr. Bautista in Wisconsin, we have recently estalished a consortium of population-based studies to evaluate the impact of obesity in Latin-American population (http://www.pophealth.wisc.edu/laso/).

From April 2009 I am working as Epidemiologist of the British Women's Heart & Health Study a cohort of over 4000 women in 23 British towns.

Selected publications

• Serrano, N.C.; Diaz, L.A.; Paez, M.C.; Mesa, C.M.; Cifuentes, R.; Monterrosa, A.; Gonzalez, A.; Smeeth, L.; Hingorani, A.D.; Casas, J.P. Angiotensin-converting enzyme I/D polymorphism and preeclampsia risk: Evidence of small-study bias Plos Medicine, 2006; 3(12):2304-2316
• Casas, J.P.; Shah, T.; Cooper, J.; Hawe, E.; McMahon, A.D.; Gaffney, D.; Packard, C.J.; O'reilly, D.S.; Juhan-Vague, I.; Yudkin, J.S.; Tremoli, E.; Margaglione, M.; Di Minno, G.; Hamsten, A.; Kooistra, T.; Stephens, J.W.; Hurel, S.J.; Livingstone, S.; Colhoun, H.M.; Miller, G.J.; Bautista, L.E.; Meade, T.; Sattar, N.; Humphries, S.E.; Hingorani, A.D.; Insight into the nature of the CRP-coronary event association using Mendelian randomization. Int J Epidemiol, 2006; 35(4):922-31
• Casas, J.P.; Bautista, L.E.; Smeeth, L.; Sharma, P.; Hingorani, A.D.; Homocysteine and stroke: evidence on a causal link from mendelian randomisation. Lancet, 2005; 365(9455):224-32
• Casas, J.P.; Chua, W.; Loukogeorgakis, S.; Vallance, P.; Smeeth, L.; Hingorani, A.D.; MacAllister, R.J.; Effect of inhibitors of the renin-angiotensin system and other antihypertensive drugs on renal outcomes: systematic review and meta-analysis. Lancet, 2005; 366(9502):2026-33
• Casas, J.P.; Bautista, L.E.; Humphries, S.E.; Hingorani, A.D.; Endothelial nitric oxide synthase genotype and ischemic heart disease: meta-analysis of 26 studies involving 23028 subjects. Circulation, 2004; 109(11):1359-65
• Maas, R.; Böger, R.H.; Schwedhelm, E.; Casas, J.P.; López-Jaramillo, P.; Serrano, N.; Díaz, L.A.; Plasma concentrations of asymmetric dimethylarginine (ADMA) in Colombian women with pre-eclampsia. JAMA, 2004; 291(7):823-4

Full publications listing (since 2001)