Miles Lab, Leishmania donovani
Molecular taxonomy and phylogeny of the Leishmania donovani complex, and implications for epidemiological and clinical research
Principal investigator: Michael Miles
Co-Investigators: Isabel Mauricio, Michael Gaunt
Objectives:
- Devise new molecular methods for taxonomic and population genetics research on the Leishmania donovani complex
- Reevaluate the taxonomy of the L.donovani complex
- Improve molecular methods for the rapid identification of Leishmania
- Investigate the capacity for genetic recombination in the Leishmania donovani complex
- Investigate the relevance of canine and other reservoir hosts to the control of visceral leishmaniasis
- Clarify the evolutionary history of the Leishmania donovani complex
- Strengthen European collaboration in research on leishmaniasis
Output from the project :
- Elnaeim, D.A., Ward, R.D., Hassan, H.K., Miles, M.A. and Frame, I.A. (1998) Infection rates of Leishmania donovani in Phlebotomus orientalis from a focus of visceral leishmaniasis in eastern Sudan. Ann. Trop. Med. Parasitol. 92:229-232
- Vexenat, J.A., Olliaro, P.L., Fonseca de Castro, J.A., Cavalcante, R., Furtado Campos, J.H., Tavares, J.P. and Miles, M.A. (1998) Clinical recovery and limited cure in canine visceral leishmaniasis treated with aminosidine (paromomycin). Amer. J. Trop. Med. Hyg. 58: 448-453.
- Mauricio, I.L., Howard, M.K., Stothard, J.R. and Miles, M.A. (1999) Genomic diversity in the Leishmania donovani complex. Parasitology 119: 237-246.
- Miles, M.A., Vexenat, J.A., Furtado Campos, J.H. and Fonseca de Castro, J.A. (1999) Canine leishmaniasis in Latin America: control strategies for visceral leishmaniasis. In: Canine Leishmaniasis: an update. Hoechst Roussel Vet. pp. 46-53.
- Mauricio, I.L., Stothard, J.R. and Miles, M.A. (2000) The strange case of Leishmania chagasi. Parasitol. Today 16: 188-189
- Mauricio, I.L., Gaunt, M.W., Stothard, J.R and Miles, M.A. (2001) Genetic typing and phylogenetic analysis of the Leishmania donovani complex by restriction of the PCR amplified gp63 intergenic regions. Parasitology, in press.
- Dia, E., Hassan, N.M, Maingon, R., Nureldin, G.H., Miles, M.A. and Ward, R.D. (2001) The Egyptian mongoose (Herpestes ichneumon) as a possible host of visceral leishmaniasis in Eastern Sudan. Parasitology, in press.
