Age-related macular degeneration (AMD) is the major cause of vision loss in developed countries but little is known about this condition in developing countries. The INDEYE Study of people aged 60 and over in India (funded by the Wellcome Trust) has found a low prevalence of AMD compared to western populations. We are now investigating whether this difference can be explained genetic factors. In contrast 70% of the INDEYE study population had cataracts possibly due to low levels of antioxidant vitamins and exposure to cooking fuels. In collaboration with colleagues at Imperial college we showed that treatment of hypertension in people aged 80 and over (HYVET Trial) improves survival and reduces mortality from stroke and heart failure.