HPTN 071 (PopART)
The HPTN 071 study, also known as PopART (Population Effects of Antiretroviral Therapy to reduce HIV Transmission), is a large community-randomized trial being carried out in South Africa and Zambia to evaluate the impact of a universal test-and-treat intervention on population-level HIV incidence.
HIV prevalence and incidence remain at a very high level in many parts of Southern Africa and there is an urgent need for more effective prevention measures. Mathematical models have shown that universal voluntary HIV counselling and testing, with the offer of immediate antiretroviral treatment (ART) for those testing HIV-positive, has the potential to achieve substantial reductions in HIV incidence at population level. Testing the effectiveness of this strategy, in combination with proven preventive interventions, is a key global health priority.
The HPTN 071 (PopART) trial aims to measure the costs and benefits of a combination prevention package including door-to-door voluntary HIV testing, immediate treatment for HIV-infected individuals regardless of CD4 count and promotion of male circumcision for HIV-uninfected men. Another major goal of the study is to determine whether it is possible and affordable to deliver this combination prevention package on a large scale.
The study is being carried out in 21 communities (9 communities in the Western Cape of South Africa and 12 communities in Zambia) over a period of 5 years, from 2013 to 2017.