Professor Brendan Wren FRCPath

Professor Microbial Pathogenesis

• Affiliation
• Teaching
• Research
• Publications

• 
• Room 381
• LSHTM
• Keppel Street
• London
• WC1E 7HT
• T: +44 (0) 20 7927 2288
• F: +44 (0) 20 7637 4314

Brendan Wren joined the School with his research team in July 1999. His research interests include determining the genetic basis by which bacteria cause disease. The research group exploits a range of post genome research strategies to gain a comprehensive understanding of how these pathogens function and how they interact with their respective hosts. Specific areas include the role of glycosylation in bacteria and exploitation of these systems for glycoengineering and vaccine design. Co-editor (with Brian D. Robertson) of "Systems Microbiology: Current Topics and Applications", which is due for publication in June 2012 http://www.horizonpress.com/systemsmicrobiology

Affiliation

• Department of Pathogen Molecular Biology

Teaching

Brendan Wren is a member of the board of examiners for the MSc in Medical Microbiology (MM) and also lectures on this course.

Research

Current research focuses on:

1. Glycosylation in bacterial pathogens, glycoprospecting and glycoengineering

2. Comparative phylogenomics and the evolution of bacterial virulence

3. Mechanisms of bacterial pathogenesis

Research on individual pathogens include; Campylobacter jejuni, Helicobacter pylori, Clostridium difficile, Burkholderia pseudomallei and the enteropathogenic Yersinia.

Campylobacter Resource Facility link.

• Selected publications

• Biofilm Development on Caenorhabditis elegans by Yersinia Is Facilitated by Quorum Sensing-Dependent Repression of Type III Secretion

  Atkinson, S.; Goldstone, R.J.; Joshua, G.W.P.; Chang, C.Y.; Patrick, H.L.; Camara, M.; Wren, B.W.; Williams, P.

  Plos Pathogens, 2011; 7(1):e1001250

• Evolutionary dynamics of Clostridium difficile over short and long time scales.

  He, M.; Sebaihia, M.; Lawley, T.D.; Stabler, R.A.; Dawson, L.F.; Martin, M.J.; Holt, K.E.; Seth-Smith, H.M.; Quail, M.A.; Rance, R.; Brooks, K.; Churcher, C.; Harris, D.; Bentley, S.D.; Burrows, C.; Clark, L.; Corton, C.; Murray, V.; Rose, G.; Thurston, S.; van Tonder, A.; Walker, D.; Wren, B.W.; Dougan, G.; Parkhill, J.;

  Proc Natl Acad Sci U S A, 2010; 107(16):7527-32

• Bacterial pathogenomics

  Pallen, M.J.; Wren, B.W.

  Nature, 2007; 449(7164):835-842

• The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome

  Sebaihia, M.; Wren, B. W.; Mullany, P.; Fairweather, N. F.; Minton, N.; Stabler, R.; Thomson, N. R.; Roberts, A. P.; Cerdeno-Tarrraga, A. M.; Wang, H. W.; Holden, M. T. G.; Wright, A.; Churcher, C.; Quail, M. A.; Baker, S.; Bason, N.; Brooks, K.; Chillingworth, T.; Cronin, A.; Davis, P.; Dowd, L.; Fraser, A.; Feltwell, T.; Hance, Z.; Holroyd, S.; Jagels, K.; Moule, S.; Mungall, K.; Price, C.; Rabbinowitsch, E.; Sharp, S.; Simmonds, M.; Stevens, K.; Unwin, L.; Whithead, S.; Dupuy, B.; Dougan, G.; Barrell, B.; Parkhill, J.

  Nature Genetics, 2006; 38(7):779-786

• Functional analysis of the Campylobacter jejuni N-linked protein glycosylation pathway.

  Linton, D.; Dorrell, N.; Hitchen, P.G.; Amber, S.; Karlyshev, A.V.; Morris, H.R.; Dell, A.; Valvano, M.A.; Aebi, M.; Wren, B.W.;

  Mol Microbiol, 2005; 55(6):1695-1703

• Comparative phylogenomics of the food-borne pathogen Campylobacter jejuni reveals genetic markers predictive of infection source.

  Champion, O.L.; Gaunt, M.W.; Gundogdu, O.; Elmi, A.; Witney, A.A.; Hinds, J.; Dorrell, N.; Wren, B.W.;

  Proc Natl Acad Sci U S A, 2005; 102(44):16043-8

• N-linked glycosylation in Campylobacter jejuni and its functional transfer into E-coli

  Wacker, M.; Linton, D.; Hitchen, P. G.; Nita-Lazar, M.; Haslam, S. M.; North, S. J.; Panico, M.; Morris, H. R.; Dell, A.; Wren, B. W.; Aebi, M.

  Science, 2002; 298(5599):1790-1793

• Genome sequence of Yersinia pestis, the causative agent of plague

  Parkhill, J.; Wren, B. W.; Thomson, N. R.; Titball, R. W.; Holden, M. T. G.; Prentice, M. B.; Sebaihia, M.; James, K. D.; Churcher, C.; Mungall, K. L.; Baker, S.; Basham, D.; Bentley, S. D.; Brooks, K.; Cerdeno-Tarraga, A. M.; Chillingworth, T.; Cronin, A.; Davies, R. M.; Davis, P.; Dougan, G.; Feltwell, T.; Hamlin, N.; Holroyd, S.; Jagels, K.; Karlyshev, A. V.; Leather, S.; Moule, S.; Oyston, P. C. F.; Quail, M.; Rutherford, K.; Simmonds, M.; Skelton, J.; Stevens, K.; Whitehead, S.; Barrell, B. G.

  Nature, 2001; 413(6855):523-527

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