Professor John Whittaker

Professor of Genetic Epidemiology and Statistics

• Affiliation
• Research
• Publications

• 
• N/A
• LSHTM
• Keppel Street
• London
• WC1E 7HT
• T: +44 (0) 1438 76 6751

My training is in statistics, and I have worked mainly on statistical problems in medicine and biology, particularly genetics.

I joined the School in April 2005, having worked previously at Imperial College London and the University of Reading. Since April 2009 I have mainly worked at GlaxoSmithKline, initially as Director, Statistical Genetics, now as Vice President, Statistical Platforms and Technologies but retain a 10% appointment at the School.

Affiliation

• Department of Non-communicable Disease Epidemiology

Research

My research interests are in the application of statistics in biology and medicine, particularly human, population and quantitative genetics. In particular I have published widely on the design and analysis of genetic association studies, both population and family based. This research has been a mixture of methodological development and applied data analytic work in collaboration with data generators.

• Selected publications

• Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data.

  C Reactive Protein Coronary Heart Disease Genetics Collaboration (CCGC), . ; Wensley, F. ; Gao, P. ; Burgess, S. ; Kaptoge, S. ; Di Angelantonio, E. ; Shah, T. ; Engert, J.C. ; Clarke, R. ; Davey-Smith, G. ; Nordestgaard, B.G. ; Saleheen, D. ; Samani, N.J. ; Sandhu, M. ; Anand, S. ; Pepys, M.B. ; Smeeth, L. ; Whittaker, J. ; Casas, J.P. ; Thompson, S.G. ; Hingorani, A.D. ; Danesh, J. ;

  BMJ, 2011; 342:d548

• Genetic risk factors for variant Creutzfeldt-Jakob disease: a genome-wide association study

  Mead, S.; Poulter, M.; Uphill, J.; Beck, J.; Whitfield, J.; Webb, T.E.F.; Campbell, T.; Adamson, G.; Deriziotis, P.; Tabrizi, S.J.; Hummerich, H.; Verzilli, C.; Alpers, M.P.; Whittaker, J.C.; Collinge, J.

  Lancet Neurology, 2009; 8(1):57-66

• Multilocus Bayesian Meta-Analysis of Gene-Disease Associations.

  Newcombe, P.J.; Verzilli, C.; Casas, J.P.; Hingorani, A.D.; Smeeth, L.; Whittaker, J.C.;

  Am J Hum Genet, 2009; 84(5):567-80

• Bayesian meta-analysis of genetic association studies with different sets of markers.

  Verzilli, C.; Shah, T.; Casas, J.P.; Chapman, J.; Sandhu, M.; Debenham, S.L.; Boekholdt, M.S.; Khaw, K.T.; Wareham, N.J.; Judson, R.; Benjamin, E.J.; Kathiresan, S.; Larson, M.G.; Rong, J.; Sofat, R.; Humphries, S.E.; Smeeth, L.; Cavalleri, G.; Whittaker, J.C.; Hingorani, A.D.;

  Am J Hum Genet, 2008; 82(4):859-72

• Analysis of multiple SNPs in a candidate gene or region.

  Chapman, J.; Whittaker, J.;

  Genet Epidemiol, 2008; 32(6):560-6

• A Bayesian toolkit for genetic association studies.

  Lunn, D.J.; Whittaker, J.C.; Best, N.;

  Genet Epidemiol, 2006; 30(3):231-47

• Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease.

  Hubner, N.; Wallace, C.A.; Zimdahl, H.; Petretto, E.; Schulz, H.; Maciver, F.; Mueller, M.; Hummel, O.; Monti, J.; Zidek, V.; Musilova, A.; Kren, V.; Causton, H.; Game, L.; Born, G.; Schmidt, S.; Müller, A.; Cook, S.A.; Kurtz, T.W.; Whittaker, J.; Pravenec, M.; Aitman, T.J.;

  Nat Genet, 2005; 37(3):243-53

• Polymorphism at the C-reactive protein locus influences gene expression and predisposes to systemic lupus erythematosus.

  Russell, A.I.; Cunninghame Graham, D.S.; Shepherd, C.; Roberton, C.A.; Whittaker, J.; Meeks, J.; Powell, R.J.; Isenberg, D.A.; Walport, M.J.; Vyse, T.J.;

  Hum Mol Genet, 2004; 13(1):137-47

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