Albert VanWyk BSc PhD
- Room 490
- LSHTM
- Keppel Street
- London
- WC1E 7HT
- T: +44 (0)20 7927 2959
Albert van Wyk is a Research Fellow in the Faculty of Infectious and Tropical Diseases, at the London School of Hygiene & Tropical Medicine, London, UK. He obtained both his BSc and PhD at Rhodes University in Grahamstown, South Africa in the field of synthetic organic chemistry. Originally, his research centred on the semisynthesis of compounds with antifungal, anticancer and antimalarial properties from naturally occurring metabolites. As an extension of this research, he then moved to the National Cancer Institute (NCI) in Frederick, Maryland, USA where he worked on the bioassay guided isolation and characterisation of bioactive metabolites from marine, terrestrial and fungal sources. While at the NCI, he also played a role in optimizing and adapting a protein based assay anticancer assay to a high throughput format.
Affiliation
Research
Member of a project to detect the levels, pharmacokinetics, novel metabolites and quality of antimalarial drugs in Africa, by means of HPLC, mass spectrometry and dissolution testing. This study is funded by the Artemisinin Combination Therapy Consortium (www.actconsortium.org), via an award to LSHTM by the Bill and Melinda Gates Foundation.
Disciplines
- Pharmacology
Disease and Health Conditions
- Malaria
-
Selected publications
-
Lithothamnin A, the First Bastadin-like Metabolite from the Red Alga Lithothamnion fragilissimum.
Van Wyk, A.W. ; Zuck, K.M. ; McKee, T.C. ;
J Nat Prod, 2011;
-
Bioactive Metabolites from the South African Marine Mollusk Trimusculus costatuse
van Wyk, A.W.W.; Gray, C.A.; Whibley, C.E.; Osoniyi, O.; Hendricks, D.T.; Caira, M.R.; Davies-Coleman, M.T.
Journal of Natural Products, 2008; 71(3):420-425
-
Transformations of Manool. Tri- and Tetracyclic Norditerpenoids with in Vitro Activity against Plasmodium falciparum
van Wyk, A.W.W.; Lobb, K.A.; Caira, M.R.; Hoppe, H.C.; Davies-Coleman, M.T.
Journal of Natural Products, 2007; 70(8):1253-1258
-
Semisynthesis of labdane diterpene metabolites from the nudibranch Pleurobranchaea meckelii
van Wyk, A.W.W.; Davies-Coleman, M.T.
Tetrahedron, 2007; 63(49):12179-12184
-
New Isocopalane diterpene diester from a sub-Antarctic marine nudibranch
van Wyk, A.W.W.; Froneman, P.W.; Bernard, K.S.; Davies-Coleman, M.T.
ARKIVOC : free online journal of organic chemistry / Arkat-USA, Inc, 2007; 2007(ix):121-128
-
Synthesis and cytotoxicity of analogues of the marine secondary metabolite, 2-deoxylapachol
Sunassee, S.N.; van Wyk, A.W.W.; Osoniyi, O.; Hendricks, D.T.; Davies-Coleman, M.T.
Journal of Chemical Research, 2007; 2007:677-679
-
Transformations of hispanolone. Novel Michael adducts with in planta activity against rice blast
van Wyk, A.W.W.; Gray, C.A.; Keyzers, R.A.; Rivett, D.E.A.; Caira, M.R.; Nader, B.S.; Davis, G.E.; Werk, T.L.; Davies-Coleman, M.T.
Tetrahedron, 2005; 61(35):8493-8498
- → View all Albert VanWyk's publications
